1: Korean J Ophthalmol. 2010 Jun;24(3):192-3; author reply 193. Epub 2010 Jun 5.


Bevacizumab and triamcinolone for branch vein occlusion.

Wong IY.

Publication Types:
    Comment
    Letter

PMID: 20532151  [PubMed - in process]

2: Korean J Ophthalmol. 2010 Jun;24(3):189-91. Epub 2010 Jun 5. 

Unilateral recession-resection surgery with inferior displacement combined with
augmented anterior transposition of inferior oblique muscle.

Hong S, Hong YT, Seong GJ, Han SH.

Institute of Vision Research, Department of Ophthalmology, Yonsei University
College of Medicine, #712 Eonjuro, Gangnam-gu, Seoul, Korea.

We report the effects of unilateral recession-resection surgery of the
horizontal recti muscles with inferior displacement and augmented anterior
transposition of the inferior oblique muscle with a posterior intermuscular
suture in a patient with large exotropia and considerable hypertropia.

PMID: 20532150  [PubMed - in process]

3: Korean J Ophthalmol. 2010 Jun;24(3):186-8. Epub 2010 Jun 5. 

Presumed metastasis of breast cancer to the abducens nucleus presenting as gaze
palsy.

Han SB, Kim JH, Hwang JM.

Department of Ophthalmology, Seoul National University Bundang Hospital, #300
Gumi-dong, Bundang-gu, Seongnam, Korea.

A 51-year-old woman with breast cancer presented with progressive diplopia.
Neuro-ophthalmologic examination revealed right gaze palsy and peripheral facial
nerve palsy. Brain magnetic resonance imaging (MRI) was normal. However, two
months later a repeat brain MRI revealed an enhancing round nodular mass at the
right facial colliculus of the lower pons, at the location of the abducens
nucleus. Localized metastasis to the abducens nucleus can cause gaze palsy in a
patient with breast cancer.

PMID: 20532149  [PubMed - in process]

4: Korean J Ophthalmol. 2010 Jun;24(3):182-5. Epub 2010 Jun 5. 

Castleman's disease presenting with uveal effusion syndrome.

Park SH, Song SJ.

Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University
School of Medicine, #108 Pyeong-dong, Jongno-gu, Seoul, Korea.

We report a rare case of multicentric Castleman's disease that presented with
ophthalmic involvement, along with a review of the literature. A 63-year-old
male presented with decreased visual acuity in both eyes. Both eyes had serous
elevations of the retinas with shifting subretinal fluid and annular choroidal
detachment. No retinal breaks were found. Laboratory tests revealed
pancytopenia, hypergammaglobulinemia, and an increased erythrocyte sedimentation
rate. Chest and abdominal computed tomographies showed multiple
lymphadenopathies in the mediastinum, abdomen, and in both inguinal areas.
Histological examination of the inguinal lymph node biopsy was consistent with
Castleman's disease. After combination chemotherapy, the serous elevations of
both retinas and the annular choroidal detachments of both eyes disappeared.
Ophthalmic involvement in Castleman's disease is very rare, and to the authors'
knowledge, this is the first report of ophthalmic involvement of Castleman's
disease in Korea.

PMID: 20532148  [PubMed - in process]

5: Korean J Ophthalmol. 2010 Jun;24(3):179-81. Epub 2010 Jun 5. 

Progression of impending central retinal vein occlusion to the ischemic variant
following intravitreal bevacizumab.

Kim NR, Chin HS.

Department of Ophthalmology, Inha University School of Medicine, #7-206,
Shinheung-dong, Jung-gu, Incheon, Korea.

A 60-year-old woman who had experienced two episodes of amaurosis fugax in her
right eye presented with vision loss. Two weeks earlier, at a private clinic,
she was diagnosed with impending central retinal vein occlusion (CRVO) of the
right eye and received an intravitreal injection of bevacizumab. Two weeks after
this injection she was diagnosed with ischemic CRVO. At 11-weeks
post-presentation, extremely ischemic features were observed with fluorescein
angiographic findings of severe vascular attenuation and extensive retinal
capillary obliteration. At 22-weeks post-presentation she was diagnosed with
neovascular glaucoma; she experienced no visual improvement over the following
several months.

Publication Types:
    Research Support, Non-U.S. Gov't

PMID: 20532147  [PubMed - in process]

6: Korean J Ophthalmol. 2010 Jun;24(3):175-8. Epub 2010 Jun 5. 

Aspergillus fumigatus scleritis associated with monoclonal gammopathy of
undetermined significance.

Jo DH, Oh JY, Kim MK, Heo JW, Lee JH, Wee WR.

Department of Ophthalmology, Seoul National University College of Medicine, #28
Yeongeon-dong, Jongno-gu, Seoul, Korea.

A 68-year-old woman presented with pain in her left eye. Necrosis with calcium
plaques was observed on the medial part of the sclera. Aspergillus fumigatus was
isolated from the culture of the necrotic area. On systemic work-up including
serum and urine electrophoresis studies, the serum monoclonal protein of
immunoglobulin G was detected. The patient was diagnosed with monoclonal
gammopathy of undetermined significance and fungal scleritis. Despite intensive
treatment with topical and oral antifungal agents, scleral inflammation and
ulceration progressed, and scleral perforation and endophthalmitis developed.
Debridement, antifungal irrigation, and tectonic scleral grafting were
performed. The patient underwent a combined pars plana vitrectomy with an
intravitreal injection of an antifungal agent. However, scleral and intraocular
inflammation progressed, and the eye was enucleated. Aspergillus fumigatus was
isolated from the cultures of the eviscerated materials. Giemsa staining of the
excised sclera showed numerous fungal hyphae.

PMID: 20532146  [PubMed - in process]

7: Korean J Ophthalmol. 2010 Jun;24(3):173-4. Epub 2010 Jun 5. 

A case of irritated seborrheic keratosis associated with a previous incision
site.

Lee JP, Kim YJ.

Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym
University College of Medicine, #896 Pyungchon-dong, Anyang, Korea.

An 83-year-old woman had undergone an external dacryocystorhinostomy with
silicone intubation. Before the surgery, no skin lesions were observed on the
incision site. Three months after surgery, the patient complained of a
brown-to-black pigmented elevation at her previous skin incision site. A punch
biopsy of the pigmented mass was performed. The histopathologic findings
confirmed the clinical diagnosis of irritated seborrheic keratosis (SK). SK can
occur several months postoperatively and can suddenly increase in size, so
surgeons need to carefully check patients' skin prior to surgery. To our
knowledge, this is the first reported case of irritated SK discovered on a
previous skin incision site.

PMID: 20532145  [PubMed - in process]

8: Korean J Ophthalmol. 2010 Jun;24(3):169-72. Epub 2010 Jun 5. 

The effect of brimonidine on transepithelial resistance in a human retinal
pigment epithelial cell line.

Park JH, Kim SJ, Yu HG.

Department of Ophthalmology, Seoul Paik Hospital, Inje University College of
Medicine, Seoul, Korea.

PURPOSE: To investigate the effects of brimonidine, an alpha-2-adrenergic
agonist, on barrier function in ARPE-19 cells by measuring transepithelial
resistance (TER). METHODS: ARPE-19 cells were cultured into a confluent
monolayer on a microporous filter. Brimonidine was added to the apical medium,
and the barrier function of the cells was evaluated by measuring TER. A subset
of cells was treated under hypoxic conditions, and the TER changes observed upon
administration of brimonidine were compared to those observed in cells in
normoxic conditions. RESULTS: The ARPE cell membrane reached a peak resistance
of 29.1+/-7.97 Omegacm(2) after four weeks of culture. The TER of the cells
treated under normoxic conditions increased with brimonidine treatment; however,
the TER of the cells treated under hypoxic conditions did not change following
the administration of brimonidine. CONCLUSIONS: Barrier function in ARPE-19
cells increased with brimonidine treatment. Understanding the exact mechanism of
this barrier function change requires further investigation.

Publication Types:
    Research Support, Non-U.S. Gov't

PMID: 20532144  [PubMed - in process]

9: Korean J Ophthalmol. 2010 Jun;24(3):163-8. Epub 2010 Jun 5. 

The anti-angiogenic effect of chlorogenic acid on choroidal neovascularization.

Kim C, Yu HG, Sohn J.

Department of Ophthalmology, Incheon Medical Center, Incheon, Korea.

PURPOSE: To evaluate the inhibitory effect of chlorogenic acid on laser-induced
choroidal neovascularization (CNV) in a rat model. METHODS: Intraperitoneal
injection of chlorogenic acid (10 mg/kg) was initiated one day prior to laser
photocoagulation and continued for eight days. Eyes were removed 14 days after
laser photocoagulation. Fluorescein angiography was employed at seven and 14
days to assess the CNV lesions, and histological examination was performed.
Quantification of CNV size and leakage were performed both in histological
sections and fluorescein angiography in order to compare the inhibitory effects
of chlorogenic acid on CNV with the results of the control. RESULTS:
Histological analysis showed no significant difference in CNV size between the
treated and control groups. However, CNV leakage on fluorescein angiography had
significantly decreased in the chlorogenic acid-treated group at 14 days after
laser photocoagulation compared with that of the control group. In addition, CNV
size on fluorescein angiography had significantly decreased in the treated group
at seven and 14 days. CONCLUSIONS: These results suggest that chlorogenic acid
has anti-angiogenic effects on CNV and may be useful as an inhibitor in the
treatment or prevention of neovascular age-related macular degeneration.

PMID: 20532143  [PubMed - in process]

10: Korean J Ophthalmol. 2010 Jun;24(3):159-62. Epub 2010 Jun 5. 

Effect of illumination on colour vision testing with Farnsworth-Munsell 100 hue
test: customized colour vision booth versus room illumination.

Zahiruddin K, Banu S, Dharmarajan R, Kulothungan V, Vijayan D, Raman R, Sharma
T.

Elite School of Optometry, Sankara Nethralaya, Chennai, Tamil Nadu, India.

PURPOSE: To evaluate a customized, portable Farnsworth-Munsell 100 (FM 100) hue
viewing booth for compliance with colour vision testing standards and to compare
it with room illumination in subjects with normal colour vision (trichromats),
subjects with acquired colour vision defects (secondary to diabetes mellitus),
and subjects with congenital colour vision defects (dichromats). METHODS:
Discrete wavelengths of the tube in the customized booth were measured using a
spectrometer using the normal incident method and were compared with the
spectral distribution of sunlight. Forty-eight subjects were recruited for the
study and were divided into 3 groups: Group 1, Normal Trichromats (30 eyes);
Group 2, Congenital Colour Vision Defects (16 eyes); and Group 3, Diabetes
Mellitus (20 eyes). The FM 100 hue test performance was compared using two
illumination conditions, booth illumination and room illumination. RESULTS:
Total error scores of the classical method in Group 2 as mean+/-SD for room and
booth illumination was 243.05+/-85.96 and 149.85+/-54.50 respectively
(p=0.0001). Group 2 demonstrated lesser correlation (r=0.50, 0.55), lesser
reliability (Cronbach's alpha, 0.625, 0.662) and greater variability (Bland &
Altman value, 10.5) in total error scores for the classical method and the
moment of inertia method between the two illumination conditions when compared
to the other two groups. CONCLUSIONS: The customized booth demonstrated
illumination meeting CIE standards. The total error scores were overestimated by
the classical and moment of inertia methods in all groups for room illumination
compared with booth illumination, however overestimation was more significant in
the diabetes group.

PMID: 20532142  [PubMed - in process]

11: Korean J Ophthalmol. 2010 Jun;24(3):155-8. Epub 2010 Jun 5. 

The effect of intravitreal bevacizumab in patients with acute central serous
chorioretinopathy.

Lim JW, Ryu SJ, Shin MC.

Department of Ophthalmology, Chuncheon Sacred Heart Hospital, Hallym University
College of Medicine, #153 Gyo-dong, Chuncheon, Korea. jiwoneye@hallym.or.kr

PURPOSE: To evaluate the effect of intravitreal bevacizumab injection (IVBI) in
acute central serous chorioretinopathy (CSC) patients. METHODS: Patients with
acute CSC received IVBI (1.25 mg/0.05 mL) or observation by randomization.
Twelve eyes in each group completed 6 months of regular follow-up and were
ultimately included in this study. Each patient was assessed using best
corrected visual acuity measurements, fluorescein angiography, and optical
coherence tomography at baseline and had regular follow-ups after treatment.
RESULTS: All patients showed improvements in visual acuity and fluorescein
angiographic leakage and had resolution of their neurosensory detachment
following treatment. There were no significant differences in visual acuity,
central retinal thickness, or remission duration between the IVBI group and the
control group at baseline or after treatment (p>0.05). CONCLUSIONS: Intravitreal
bevacizumab showed no positive effect in acute CSC patients compared to the
observation group, and there were no adverse effects of treatment. Further
investigation will be helpful to understand this therapy in patients with CSC.

PMID: 20532141  [PubMed - in process]

12: Korean J Ophthalmol. 2010 Jun;24(3):148-54. Epub 2010 Jun 5. 

The epidemiology of cosmetic treatments for corneal opacities in a Korean
population.

Chang KC, Kwon JW, Han YK, Wee WR, Lee JH.

Seoul Artificial Eye Center, Seoul National University Hospital Clinical
Research Institute, Seoul, Korea.

PURPOSE: To describe etiologies and clinical characteristics of corneal
opacities leading patients to seek cosmetic treatments. METHODS: The medical
records of 401 patients who presented for cosmetic improvement in corneal
opacities between May 2004 and July 2007 were retrospectively reviewed. The
following parameters were analyzed: age, gender, cause of corneal opacity, time
course of the corneal disease, associated diseases, prior and current cosmetic
treatments, visual acuity, location and depth of the corneal opacity, and the
presence of either corneal neovascularization or band keratopathy. A single
practitioner examined all patients. RESULTS: The most common causes of corneal
opacity were ocular trauma (203 eyes, 50.6%), retinal disease (62 eyes, 15.5%),
measles (38 eyes, 9.5%), and congenital etiologies (22 eyes, 5.5%). Prior
treatments included iris colored contact lenses (125 eyes, 31.1%) and corneal
tattooing (34 eyes, 8.46%). A total of 321 of 401 eyes underwent cosmetic
treatment for corneal opacities. The most common treatment performed after the
primary visit was corneal tattooing (261 eyes, 64.92%). CONCLUSIONS: This is the
first study to investigate the causes and clinical characteristics of patients
presenting for cosmetic treatment of corneal opacities rather than for
functional improvement. Various cosmetic interventions are available for
patients with corneal opacities, and these should be individualized for the
needs of each patient.

PMID: 20532140  [PubMed - in process]

13: Korean J Ophthalmol. 2010 Jun;24(3):143-7. Epub 2010 Jun 5. 

Early postoperative pain and visual outcomes following epipolis-laser in situ
keratomileusis and photorefractive keratectomy.

Kim JH, Lee J, Kim JY, Tchah H.

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of
Medicine, #388-1 Pungnap 2-dong, Songpa-gu, Seoul, Korea.

PURPOSE: To compare early postoperative pain and visual outcomes after
epipolis-laser in situ keratomileusis (epi-LASIK) and photorefractive
keratectomy (PRK) in the treatment of myopia. METHODS: A retrospective chart
review was designed and included 49 eyes in 30 patients who underwent epi-LASIK
and 54 eyes in 29 patients who underwent PRK. During the early postoperative
period (days 1 to 5), pain, uncorrected visual acuity (UCVA), and time to
epithelial healing were recorded. Visual outcomes were followed for up to six
months. RESULTS: Mean preoperative spherical equivalent refraction for the
epi-LASIK group was -3.99+/-1.39 diopters (D) and that of the PRK group was
-3.54+/-1.27 D. The pain scores on the fourth postoperative day were
significantly higher in the epi-LASIK group than in the PRK group (p=0.017).
Duration of pain in the epi-LASIK group was longer than in the PRK group
(p=0.010). Mean healing time was significantly longer in the epi-LASIK group
than in the PRK group (p<0.000). In addition, UCVA in the epi-LASIK group at
postoperative days 1 and 3 were significantly lower than those in the PRK group
(p=0.021 and p<0.000, respectively). Uncorrected visual acuity at one week and
one month after epi-LASIK were lower than those after PRK (p=0.023 and p=0.004,
respectively). CONCLUSIONS: In the epi-LASIK patients, pain relief, corneal
healing, and visual recovery seemed to be slower during the early postoperative
period compared to those of the PRK patients. With longer duration of follow-up,
however, there were no significant differences in visual outcome between the two
groups.

PMID: 20532139  [PubMed - in process]

14: Korean J Ophthalmol. 2010 Jun;24(3):139-42. Epub 2010 Jun 5. 

Evaluation of corneal biomechanical properties following penetrating
keratoplasty using the ocular response analyzer.

Shin JY, Choi JS, Oh JY, Kim MK, Lee JH, Wee WR.

Department of Ophthalmology, Seoul National University Hospital, #28
Yeongeon-dong, Jongno-gu, Seoul, Korea.

PURPOSE: To evaluate corneal biomechanical properties in eyes that had
previously undergone penetrating keratoplasty (PK) using the ocular response
analyzer (ORA). METHODS: We recruited 26 patients who had received unilateral
PK. Corneal hysteresis (CH), corneal resistance factor (CRF),
Goldmann-correlated intraocular pressure (IOPg), and cornea-compensated
intraocular pressure (IOPcc) were measured with the ORA and were compared to the
measurements from the contralateral eyes that did not undergo PK. RESULTS: The
CH was 8.95+/-2.59 mmHg in eyes that underwent PK and 9.78+/-1.45 mmHg in the
contralateral eyes that did not undergo PK (p=0.077). The CRF was 10.26+/-2.64
mmHg in post-PK eyes and 9.75+/-1.45 mmHg in the contralateral eyes (p=0.509),
and the CH-CRF was significantly smaller in post-PK eyes (-1.31+/-2.32 mmHg in
post-PK eyes vs. 0.03+/-0.88 mmHg in fellow eyes, p=0.016). The IOPg and IOPcc
were significantly higher in the PK group than they were in the control group.
The IOPcc's were 20.81+/-7.81 mmHg and 16.27+/-2.49 mmHg in post-PK and control
eyes, respectively (p=0.011); and the IOPg's were 19.22+/-7.34 mmHg and
15.07+/-3.03 mmHg in post-PK and control eyes, respectively (p=0.019). The
IOPcc-g's were 1.59+/-2.81 mmHg and 1.21+/-1.30 mmHg in post-PK and control
eyes, respectively (p=0.412), and the central corneal thickness (CCT)'s were
489.11+/-90.60 microm and 556.24+/-42.84 microm in post-PK and control eyes,
respectively (p=0.068). CONCLUSIONS: Following PK, CH tended to decrease while
CRF tended to increase, significantly decreasing CH-CRF. A significantly higher
intraocular pressure and a thinner CCT following PK may have contributed to the
observed changes in these corneal biomechanical parameters.

PMID: 20532138  [PubMed - in process]