1: J Neuroophthalmol. 2008 Mar;28(1):81-2. 

I am a retinal migraineur.

Robertson DM.

Publication Types:
    Case Reports
    Letter

PMID: 18347471 [PubMed - indexed for MEDLINE]

2: J Neuroophthalmol. 2008 Mar;28(1):79-80; author reply 80-1. 

Comment on:
    J Neuroophthalmol. 2007 Sep;27(3):161-3.

Animal model for nonarteritic anterior ischemic optic neuropathy.

Hayreh SS.

Publication Types:
    Comment
    Letter

PMID: 18347469 [PubMed - indexed for MEDLINE]

3: J Neuroophthalmol. 2008 Mar;28(1):77-8; author reply 78-9. 

Comment on:
    J Neuroophthalmol. 2007 Sep;27(3):164-8.

Intravitreal triamcinolone for nonarteritic anterior ischemic optic neuropathy.

Hayreh SS.

Publication Types:
    Comment
    Letter

PMID: 18347467 [PubMed - indexed for MEDLINE]

4: J Neuroophthalmol. 2008 Mar;28(1):76-7. 

Stepwise decline in visual field after serial sildenafil use.

Pepin S, Pitha-Rowe I.

Publication Types:
    Case Reports
    Letter

PMID: 18347466 [PubMed - indexed for MEDLINE]

5: J Neuroophthalmol. 2008 Mar;28(1):75. 

Bilateral posterior ischemic optic neuropathy associated with use of sildenafil.

Su DH, Ang PS, Tow SL.

Publication Types:
    Case Reports
    Letter

PMID: 18347465 [PubMed - indexed for MEDLINE]

6: J Neuroophthalmol. 2008 Mar;28(1):72-4. 

Open access mandate threatens dissemination of scientific information.

McMullan E.

Lippincott Williams & Wilkins, Philadelphia, Pennsylvania 19106, USA.
Erin.mcmullan@wolterskluwer.com

The public good is served when researchers can most easily access current,
high-quality research through articles that have undergone rigorous peer review
and quality control processes. The free market has allowed researchers excellent
access to quality research articles through the investment of societies and
commercial publishers in these processes for publication of scholarly journals
in a wide variety of specialty and subspecialty areas. Government legislation
mandating "open access" to copyrighted articles through a government Web site
could result in a reduction of financially sustainable peer-reviewed journals
and a reduction in the overall quality of articles available as publishers,
societies, and authors are forced to hand over their intellectual property or
restrict the peer review process because of lost sales opportunities. The public
is best served when the work of researchers advances science to its benefit. If
researchers have fewer current resources, diminished quality control, or access
to fewer trusted peer-reviewed journals, the public could ultimately lose more
than it could gain from open access legislation.

Publication Types:
    Editorial

PMID: 18347464 [PubMed - indexed for MEDLINE]

7: J Neuroophthalmol. 2008 Mar;28(1):69-71. 

Expanding access to published research: open access and self-archiving.

Mower A, Youngkin ME.

University of Utah Eccles Health Sciences Library, Salt Lake City, Utah 84112,
USA. amower@lib.med.utah.edu

Academic libraries traditionally provide access to the life science journal
literature for their respective institutions by purchasing annual subscriptions
to journals. However, with skyrocketing subscription prices and decreased or
flattened library budgets, fewer journals are being purchased. This trend
results in diminished access to the literature for members of that institution.
Open access and self-archiving are possible solutions to this crisis.

Publication Types:
    Editorial

PMID: 18347463 [PubMed - indexed for MEDLINE]

8: J Neuroophthalmol. 2008 Mar;28(1):58-68. 

Neuro-ophthalmologic manifestations of paraneoplastic syndromes.

Ko MW, Dalmau J, Galetta SL.

Department of Neurology, University of Pennsylvania School of Medicine,
Philadelphia, Pennsylvania, USA. melissaw.ko@uphs.upenn.edu

Paraneoplastic syndromes with neuro-ophthalmologic manifestations may involve
the central nervous system, cranial nerves, neuromuscular junction, optic nerve,
uvea, or retina. Most of these disorders are related to immunologic mechanisms
presumably triggered by the neoplastic expression of neuronal proteins. Accurate
recognition is essential to appropriate management.

Publication Types:
    Review

PMID: 18347462 [PubMed - indexed for MEDLINE]

9: J Neuroophthalmol. 2008 Mar;28(1):55-7. 

Presumed bilateral optic nerve sheath meningiomas presenting as optic neuritis.

Sawaya RA, Sidani C, Farah N, Hourani-Risk R.

Department of Neurology, American University of Beirut Medical Center, Beirut,
Lebanon. rs01@aub.edu.lb

A 30-year-old man who developed acute blurred vision in the right eye and right
periocular pain on eye movement proved to have a bilateral optic neuropathy and
imaging evidence suggestive of bilateral optic nerve sheath meningiomas. This is
an unusual presentation for optic nerve meningioma but a reminder that this
entity may mimic optic neuritis.

Publication Types:
    Case Reports

PMID: 18347461 [PubMed - indexed for MEDLINE]

10: J Neuroophthalmol. 2008 Mar;28(1):51-4. 

Homonymous hemianopia caused by solitary skull metastasis of hepatocellular
carcinoma.

Hsu SY, Chang FL, Sheu MM, Tsai RK.

Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.

We report a patient who developed a complete left homonymous hemianopia from
mass effect of a solitary skull metastasis of hepatocellular carcinoma (HCC).
After chemoembolization and resection, the visual field defect improved
markedly. This is the first reported case demonstrating this phenomenon in HCC.
It supports aggressive treatment of a solitary skull metastasis in this setting.

Publication Types:
    Case Reports

PMID: 18347460 [PubMed - indexed for MEDLINE]

11: J Neuroophthalmol. 2008 Mar;28(1):47-50. 

Orbital metastasis of hepatocellular carcinoma.

Hirunwiwatkul P, Tirakunwichcha S, Meesuaypong P, Shuangshoti S.

Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University,
Bangkok, Thailand. parima.h@chula.ac.th

We report a 74-year-old woman who presented with an orbital apex syndrome and
pulsatile proptosis. CT showed a right orbital mass that destroyed the orbital
sphenoid bone and extended intracranially. Biopsy revealed metastatic
hepatocellular carcinoma (HCC), and subsequent investigations demonstrated a
high level of serum-fetoprotein and a huge liver mass. The patient died shortly
after the biopsy. Rarely reported in the English literature, metastatic HCC is
common in Asia, perhaps because of a racial predisposition together with a
relatively high prevalence of alcoholic cirrhosis, chronic hepatitis B and C,
and exposure to aflatoxins.

Publication Types:
    Case Reports

PMID: 18347459 [PubMed - indexed for MEDLINE]

12: J Neuroophthalmol. 2008 Mar;28(1):41-6. 

Multiple intracranial meningiomas causing papilledema and visual loss in a
patient with nevoid Basal cell carcinoma syndrome.

Pribila JT, Ronan SM, Trobe JD.

Department of Ophthalmology, Kellogg Eye Center, University of Michigan, Ann
Arbor, Michigan, USA. jdtrobe@umich.edu

A 27-year-old man with nevoid basal cell carcinoma syndrome (NBCCS, Gorlin
syndrome) who had undergone craniospinal irradiation for a childhood brain stem
medulloblastoma complained of progressive binocular visual loss. Ophthalmologic
examination disclosed subnormal visual acuity and visual fields in both eyes
attributed to chronic papilledema. Brain MRI demonstrated mass effect from
multiple large meningiomas. After embolization and surgical resection of the
largest meningioma, papilledema disappeared and visual dysfunction resolved
partially. This is the sixth reported patient with NBCCS, medulloblastoma, and
craniospinal radiation who has developed intracranial meningioma, further
documenting the fact that such patients have a relatively high likelihood of
developing meningiomas, especially multiple meningiomas. Because patients with
NBCCS are often mentally impaired and because papilledema can progress silently
before causing irreversible visual loss, periodic ophthalmologic examination is
advisable after craniospinal radiation.

Publication Types:
    Case Reports

PMID: 18347458 [PubMed - indexed for MEDLINE]

13: J Neuroophthalmol. 2008 Mar;28(1):36-40. 

Isolated lymphoma of the anterior visual pathway diagnosed by optic nerve
biopsy.

Zelefsky JR, Revercomb CH, Lantos G, Warren FA.

Department of Ophthalmology, New York University School of Medicine, New York,
New York 10016, USA. jzelefsk@yahoo.com

A 72-year-old previously healthy man developed rapidly progressive visual loss,
and brain imaging showed features suggestive of a malignant glioma of the
anterior visual pathway. Biopsy of one optic nerve yielded a diagnosis of
lymphoma. There was no evidence of an extracranial non-Hodgkin lymphoma, so the
conclusion was that this represented a primary central nervous system lymphoma
(PCNSL). PCNSL isolated to the optic chiasm has been described only once in an
immunocompetent patient. Our patient is unusual in that the lymphoma involved
the optic nerve, chiasm, and tract in an immunocompetent patient.

Publication Types:
    Case Reports

PMID: 18347457 [PubMed - indexed for MEDLINE]

14: J Neuroophthalmol. 2008 Mar;28(1):31-5. 

Third cranial nerve palsy caused by intracranial extension of a sino-orbital
natural killer T-cell lymphoma.

Chen CS, Miller NR, Lane A, Eberhart C.

Department of Ophthalmology, The Johns Hopkins Hospital, Baltimore, Maryland,
USA.

Natural killer/T-cell lymphomas (NKTLs) are rare destructive lesions that
usually involve the nasal cavity or paranasal sinuses. Orbital and intracranial
involvement is rare. A 53-year-old man with systemic lupus erythematosus who was
receiving chronic low-dose prednisone treatment developed proptosis of the right
eye. Biopsy of a sino-orbital lesion suggested nonspecific inflammation.
Clinical and imaging manifestations resolved with a higher dose of prednisone,
but when the prednisone dose was tapered, the patient developed a complete right
third cranial nerve palsy. Imaging showed return of the original lesion, now
with intracranial extension and enhancement of the right third cranial nerve.
Repeat biopsy showed features consistent with NKTL. Biopsy of this lesion in its
early stage may misleadingly suggest a primary inflammatory disorder because of
a paucity of neoplastic cells, a large number of inflammatory cells recruited by
the innate natural killer (NK) cell immune response, and extensive necrosis
caused by angiodestructive tumor cells.

Publication Types:
    Case Reports

PMID: 18347456 [PubMed - indexed for MEDLINE]

15: J Neuroophthalmol. 2008 Mar;28(1):27-30. 

Long-term survival in paraneoplastic opsoclonus-myoclonus syndrome associated
with small cell lung cancer.

Hassan KA, Kalemkerian GP, Trobe JD.

Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA.

Paraneoplastic opsoclonus-myoclonus syndrome (OMS) is associated with small cell
lung cancer (SCLC) in adults. Without appropriate treatment for SCLC, all
reported patients with SCLC and OMS have died of complications of OMS within 3
months of diagnosis. With appropriate treatment, about half of reported patients
have had improvement in neurologic function, and several have become long-term
survivors (6-84 months). We report a patient with SCLC who presented with OMS
and was refractory to immunosuppressive therapy but responded rapidly to
antineoplastic therapy and remains alive with no sign of SCLC recurrence and
minimal residual neurologic deficits 30 months after diagnosis. In patients
presenting with OMS, early recognition and treatment of the underlying
malignancy probably improve the chances for recovery from the OMS with minimal
deficit and ultimate survival.

Publication Types:
    Case Reports

PMID: 18347455 [PubMed - indexed for MEDLINE]

16: J Neuroophthalmol. 2008 Mar;28(1):23-6. 

Improvement in visual fields in a patient with melanoma-associated retinopathy
treated with intravenous immunoglobulin.

Subhadra C, Dudek AZ, Rath PP, Lee MS.

Division of Hematology, Oncology, and Transplantation (CS, AZD), University of
Minnesota, Minneapolis, Minnesota 55455, USA.

Melanoma-associated retinopathy (MAR) is a rare disorder characterized by
photopsias, shimmering vision, nyctalopia, and dysfunction of rod photoreceptor
cells. We describe a 56-year-old man with metastatic cutaneous melanoma to the
lymph nodes and MAR. He underwent resection of the metastasis followed by
radiation therapy. Over the ensuing 2 months, visual function worsened so he was
treated with intravenous immunoglobulin (IVIg). Visual fields, but not
electroretinography, improved steadily over the next year. No evidence of
recurrence or metastatic disease has been found. Our patient indicates that even
after a reduction or elimination of melanoma tumor burden and presumably the
attenuation of the antigenic stimulus driving MAR, this disorder can continue to
progress. In this setting, IVIg therapy should be considered a viable treatment
option.

Publication Types:
    Case Reports
    Research Support, Non-U.S. Gov\'t

PMID: 18347454 [PubMed - indexed for MEDLINE]

17: J Neuroophthalmol. 2008 Mar;28(1):17-22. 

High-titer collapsin response-mediating protein-associated (CRMP-5)
paraneoplastic optic neuropathy and Vitritis as the only clinical manifestations
in a patient with small cell lung carcinoma.

Margolin E, Flint A, Trobe JD.

Department of Ophthalmology , Kellogg Eye Center, University of Michigan, Ann
Arbor, Michigan, USA.

Paraneoplastic optic neuropathy (PON) is a rare syndrome usually associated with
small cell lung carcinoma. In the 27 rigorously reported cases, neurologic
manifestations other than visual loss have been present in all but 2. In the
single case in which vision improved in response to treatment of the cancer, the
collapsin response-mediating protein (CRMP)-5 titer did not change, and the
ophthalmic examination was not detailed. We describe a patient with optic
neuropathy and vitritis as the only clinical manifestations of PON marked by an
extremely high titer of CRMP-5 antibody. Treatment of the underlying small cell
lung cancer coincided with resolution of the visual abnormalities and a dramatic
decrease in the CRMP-5 titer.

Publication Types:
    Case Reports

PMID: 18347453 [PubMed - indexed for MEDLINE]

18: J Neuroophthalmol. 2008 Mar;28(1):12-6. 

Histopathologic features of multiple myeloma involving the optic nerves.

Yeung SN, Paton KE, Dorovini-Zis K, Chew JB, White VA.

Department of Ophthalmology and Visual Sciences, Eye Care Centre, Vancouver,
British Columbia, Canada. sonia.y@gmail.com

We report a case of optic nerve involvement by multiple myeloma in which
progressive visual loss heralded leukemic transformation and intracranial
involvement. Imaging showed enhancing nodules in the intracranial segments of
both optic nerves posterior to the optic canals and in the anterior optic tract,
optic chiasm, and basal leptomeninges. Postmortem histopathologic examination
disclosed malignant plasma cells in the subarachnoid spaces around the optic
nerves and in the optic nerves. Infarctions were present in both optic nerves
near their junction with the globes. Microscopic examination also showed
malignant plasma cell infiltration of the leptomeninges of the cerebrum, brain
stem, optic chiasm, pituitary gland, cranial bone marrow, and subarachnoid blood
vessels. This is the first reported histopathologic examination in conjunction
with MRI of multiple myeloma involving the anterior visual pathway. The
mechanism of optic neuropathy in this case is probably related to infiltration
of the optic nerve meninges by malignant plasma cells and impaired vascular
supply caused by aggregated intraluminal plasma cells and monoclonal
hypergammaglobulinemia.

Publication Types:
    Case Reports

PMID: 18347452 [PubMed - indexed for MEDLINE]

19: J Neuroophthalmol. 2008 Mar;28(1):5-11. 

Frequency of anti-retinal antibodies in normal human serum.

Shimazaki K, Jirawuthiworavong GV, Heckenlively JR, Gordon LK.

Molecular Biology Institute, University of California, Los Angeles David Geffen
School of Medicine, Los Angeles, California, USA.

BACKGROUND: Anti-retinal antibodies have been described in the context of
autoimmune retinopathies and are often presumed to be pathogenic or disease
associated. However, full characterization of patterns of anti-retinal antibody
reactivity in normal human serum has been limited. The purpose of this work was
to identify the profile of anti-retinal IgG antibodies in serum used as controls
in laboratory testing. METHODS: Normal human sera used in commercial diagnostic
laboratories were tested for the presence of immunoreactivity against soluble
human retinal proteins using Western blot analysis of fractionated soluble human
retinal proteins. Reactivity was quantified using computerized densitometry, and
the level of reactivity was standardized relative to a control positive serum
with known reactivity against recoverin. RESULTS: Some anti-retinal reactivity
was observed in the majority of all tested normal sera. Reactivity against one
to two protein bands was observed in 33%. Reactivity against five or more
distinct bands was observed in 22%. There was a tendency for serum from women to
react with three or more protein bands compared with serum from men.
CONCLUSIONS: The presence of anti-retinal antibodies is observed in a majority
of normal control human sera, suggesting that identification of new candidate
retinal autoantigens should be cautiously interpreted and subject to rigorous
testing for disease association. Additional studies will aid development of a
standardized protocol for validation of potential pathogenic seroreactivity.

Publication Types:
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov\'t

PMID: 18347451 [PubMed - indexed for MEDLINE]

20: J Neuroophthalmol. 2008 Mar;28(1):1-4. 

The crisis in scholarly publishing: open access to the rescue?

Oren GA.

Publication Types:
    Editorial
    Introductory Journal Article

PMID: 18347450 [PubMed - indexed for MEDLINE]