1: Eur J Ophthalmol. 2012 Jan 27;:0 [Epub ahead of print] 

Randomized, phase III study comparing osmoprotective carboxymethylcellulose with
sodium hyaluronate in dry eye disease.

Baudouin C, Cochener B, Pisella PJ, Girard B, Pouliquen P, Cooper H,
Creuzot-Garcher C.

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris - France;
Institut de la Vision, UMRS 968, UPMC, Paris - France.

Purpose. To compare a treatment containing carboxymethylcellulose (CMC) and the
osmoprotective (OsPr) compatible osmolytes erythritol, L-carnitine, and glycerin
(OsPr-CMC) with a standard sodium hyaluronate (Na-HY) formulation in patients
with dry eye disease. Methods. This was a 3-month, phase III, noninferiority
study. Patients were randomized 1:1 to receive OsPr-CMC (OPTIVE(R)) or Na-HY
(VISMED(R)). The primary efficacy outcome was the mean change from baseline in
total ocular staining at day 35, scored using the 15-point Oxford scale.
Noninferiority was assessed using the adjusted means. The secondary efficacy
outcome was change in ocular surface disease index (OSDI) score from baseline to
day 35. Other outcomes included tear osmolarity, Schirmer-I test score, OSDI,
ease of use, patient acceptability, tolerability, and safety. Results. A total
of 82 patients were randomized. The primary efficacy analysis was per protocol
(OsPr-CMC, n=37; Na-HY, n=29). OsPr-CMC was noninferior to Na-HY in terms of
adjusted mean change (SE) in ocular staining score at day 35: -2.0 (0.33) with
OsPr-CMC vs -1.7 (0.37) with Na-HY. Similar improvements were seen in tear
osmolarity, Schirmer-I test score, OSDI, and ocular staining for OsPr-CMC and
Na-HY. More patients treated with OsPr-CMC vs Na-HY liked using their eyedrops,
reported that their eyes felt comfortable, and found the treatment easy to use.
Both treatments were well tolerated, with no serious treatment-related adverse
events. Conclusions. Compared with Na-HY, OsPr-CMC was noninferior in terms of
efficacy and safety, preferred by patients, and easier to use. Osmoprotection
using OsPr-CMC therefore represents a viable option for dry eye disease
management.

PMID: 22287172  [PubMed - as supplied by publisher]

2: Eur J Ophthalmol. 2012 Jan 27;:0 [Epub ahead of print] 

Author reply: Pseudoexfoliation syndrome and cataract surgery.

Romero-Aroca On Behalf Of All Authors P.

Ophthalmology Service, Hospital Universitari Sant Joan, IISPV, Universidad
Rovira i Virgili, Reus - Spain.

PMID: 22287171  [PubMed - as supplied by publisher]

3: Eur J Ophthalmol. 2012 Jan 26;:0 [Epub ahead of print] 

Bleb-associated endophthalmitis in a Chinese population (2003-2010): clinical
characteristics and visual outcome.

Ye H, Sun X, Gan D, Yu X, Zhou W, Xu G, Jiang R.

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai -
P.R. China.

Purpose. To analyze the clinical characteristics and treatment outcomes of
patients with bleb-associated endophthalmitis (BAE) in a Chinese population.
Methods. A retrospective review of patients treated for BAE between January 2003
and December 2010 in a single institution was performed. Data on visual acuity
(VA), clinical characteristics, causative organisms, and treatment outcomes were
collected and analyzed. Results. Thirty-one eyes from 31 patients with BAE were
identified during the study period. Primary open-angle glaucoma was the most
common type of glaucoma in this series (18 eyes, 58.1%). The time between
glaucoma filtering surgery and diagnosis of endophthalmitis ranged from 18 days
to 32 years, with a mean of 6.95+/-8.22 years. Nine eyes (32.1%) were culture
positive, and the most common organisms identified were Staphylococcus species
(6/9, 66.7%). Best-corrected VA at 12 months after treatment ranged from 20/30
to no light perception (NLP). Twelve (38.7%) eyes achieved VA of 20/400 or
better, and 7 (22.6%) eyes had NLP. In patients undergoing initial
tap-and-inject treatment, the eyes with presenting VA of finger count or better
were associated with a higher treatment success rate (87.5%) than those of hand
movement (33.3%) or light perception or NLP (9.1%). Conclusions. Primary
open-angle glaucoma was the most common type of glaucoma, and Staphylococcus
species was the most common causative organism in this case series of BAE.
Despite prompt treatment with appropriate intravitreal antibiotics, BAE still
carries a poor visual prognosis.

PMID: 22287170  [PubMed - as supplied by publisher]

4: Eur J Ophthalmol. 2012 Jan 27;:0 [Epub ahead of print] 

Anomalous head posturing in essential infantile esotropia: a hypothesis.

Nucci P, Hertle RW.

Eye Clinic San Giuseppe Hospital, University of Milan, Milan - Italy.

PMID: 22287169  [PubMed - as supplied by publisher]

5: Eur J Ophthalmol. 2012 Jan 27;:0 [Epub ahead of print] 

Contrast sensitivity and color perception with orange and yellow intraocular
lenses.

Munoz G, Belda-Salmeron L, Albarran-Diego C, Ferrer-Blasco T, Fernandez-Porrero
A.

Refractive Surgery Department, Centro Oftalmologico Marques de Sotelo, Valencia
- Spain.

Purpose. To evaluate contrast sensitivity function (CSF) and color vision after
implantation of either orange or yellow-tinted intraocular lenses (IOLs).
Methods. Fifty-six eyes of 28 cataract patients who had bilateral implantation
of orange-tinted (PC440Y Orange, Ophtec), yellow-tinted (AcrySof Natural SN60AT,
Alcon), or clear (AcrySof SA60AT, Alcon) IOLs were examined. Six months
postoperatively, monocular CSF under photopic and mesopic (with and without
glare) conditions were measured using the Functional Visual Analyzer. Color
discrimination was determined with the Farnsworth-Munsell 100-Hue test. Results.
Patients implanted with orange-tinted, yellow-tinted, or clear IOLs displayed
similar CSF values, with no statistically significant differences at any spatial
frequency (p>0.05). There were no statistically significant differences in
chromatic discrimination among the 3 groups of patients (p>0.05).  Conclusions.
Orange or yellow blue-filtering IOL implantation is comparable to a clear IOL in
terms of photopic and mesopic contrast sensitivity or color discrimination.

PMID: 22287168  [PubMed - as supplied by publisher]

6: Eur J Ophthalmol. 2012 Jan 27;:0 [Epub ahead of print] 

Pseudoexfoliation syndrome and cataract surgery.

Carifi G.

Moorfields Eye Hospital, London - UK.

PMID: 22287167  [PubMed - as supplied by publisher]

7: Eur J Ophthalmol. 2012 Jan 26;:0 [Epub ahead of print] 

Phacoemulsification and goniosynechialysis for the management of refractory
acute angle closure.

Fakhraie G, Vahedian Z, Moghimi S, Eslami Y, Zarei R, Faraji Oskouee J.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences,
Tehran - Iran.

Purpose. To evaluate the effectiveness of phacoemulsification with
goniosynechialysis in the management of refractory acute angle closure (AAC).
Methods. In this prospective, noncomparative interventional case series,
patients with AAC who were unresponsive to medical and laser therapy were
included. Success was defined as complete if intraocular pressure (IOP) had a
drop of at least 30% and was between 6 and 21 mmHg without medication, and
qualified if IOP was within that range with medication. Results. A total of 24
patients with a mean age of 56 years (range 39-77) were treated. Mean follow-up
time was 15.7+/-4.2 months (range 6-24). Mean preoperative and last visit IOPs
were 34.27+/-7.23 mmHg and 17.5+/-3.21 mmHg, respectively (p<0.001). Mean number
of glaucoma medication dropped from 3.67+/-0.48 to 0.63+/-1.05 (p<0.001). There
was a positive correlation between the attack-surgery interval and last visit
IOP (p<0.001, r=0.697). There was a negative correlation between the
preoperative anterior chamber depth and last visit IOP drop (p=0.03, r=-0.56).
Also, a positive correlation was found between the preoperative IOP and last
visit IOP drop (p<0.001, r=0.896). At final visit, complete and qualified
success was achieved in 17/24 (71%) and 5/24 (21%) cases, respectively. The most
common intraoperative and postoperative complications were hyphema and anterior
chamber fibrinous reaction, respectively. Conclusions. Phacoemulsification with
goniosynechialysis seems to be a safe and effective method for the management of
patients with refractory AAC. This procedure can be considered for these
patients before proceeding with filtering surgery.

PMID: 22287166  [PubMed - as supplied by publisher]

8: Eur J Ophthalmol. 2012 Jan 27;:0 [Epub ahead of print] 

24-Hour variation of optical coherence tomography-measured retinal thickness in
diabetic macular edema.

Kotsidis ST, Lake SS, Alexandridis AD, Ziakas NG, Ekonomidis PK.

1st Department of Ophthalmology, AHEPA University Hospital, Thessaloniki -
Greece.

Purpose. To investigate 24-hour variation in retinal thickness in patients with
diabetic macular edema (DME) using optical coherence tomography (OCT). Methods.
Fifty-three eyes of 53 diabetic patients with clinically significant macular
edema and central subfield thickness (CST) >225 microm, 36 eyes of 36 healthy
individuals (normal controls), and 22 eyes of 22 diabetic patients without
macular pathology (diabetic controls) underwent 5 OCT measurements at 7 am, 10
am, 3 pm, 8 pm, and 1 am. Visual acuity, blood pressure, blood glucose, and body
temperature were measured as well. Results. The CST (p<0.0005), total macular
volume (p<0.0005), and visual acuity (p<0.0005) showed significant variation in
patients. The CST (450 microm at 7 am) reached a minimum at 3 pm (absolute
change of -49 microm, relative change of -17%) before increasing again.
Thickening changes were higher in more thickened retinas (p<0.0005, p=0.024,
absolute and relative change, respectively). Visual acuity was worse in the
morning (0.38 logMAR) and improved to a maximum at 8 pm (0.30 logMAR)
(p<0.0005). Blood pressure, blood glucose, and body temperature did not vary
over time. Conclusions. The 24-hour variation of retinal thickness is observed
in a large proportion of patients with DME, with a decrease from morning to
afternoon. Time of examination should be taken into account when managing such
patients.

PMID: 22287165  [PubMed - as supplied by publisher]

9: Eur J Ophthalmol. 2012 Jan 13;:0 [Epub ahead of print] 

Impression cytology of the ocular surface and tear function in patients with
periocular vitiligo.

Serin D, Buttanri IB, Parlak AH, Boran C, Tirak E.

Haydarpasa Numune Education and Research Hospital, II. Eye Clinic, Istanbul -
Turkey.

Purpose. We evaluated the ocular surface and tear function in patients with
periocular vitiligo in this prospective, case-control study. Methods. Sixty eyes
of 30 vitiligo patients with periocular involvement and 100 eyes of 50 control
subjects were included in the study. Patients and control subjects were compared
for Schirmer test and tear film break-up time (BUT) results and impression
cytology findings graded according to Nelson's classification. Results. The mean
BUT value was 9.5+/-4.1 seconds in patients with periocular vitiligo and
13.1+/-4.2 seconds in the control group. The difference was statistically
significant (p=0.005). Thirty-seven eyes (61.7%) in the vitiligo group and 28
eyes (28.0%) in the control group had BUT values less than 10 seconds (p<0.001).
The mean Schirmer test value was 14.6+/-4.3 mm in patients with periocular
vitiligo and 15.1+/-4.4 mm in the control group (p>0.05). Nineteen eyes (31.7%)
in patients with periocular vitiligo and 8 eyes (8.0%) in the control group had
grade 2-3 changes according to Nelson's classification (p<0.001). Three eyes
(5.0%) in the periocular vitiligo group and none of the eyes in the control
group had inflammation signs in the impression cytology analysis. Conclusions.
In patients with periocular vitiligo, ocular surface and tear function
alterations may occur. Further studies on ocular surface involvement in
periocular vitiligo patients may help to increase understanding of the
pathophysiology of vitiligo.

PMID: 22267461  [PubMed - as supplied by publisher]

10: Eur J Ophthalmol. 2012 Jan 11;:0 [Epub ahead of print] 

Impact of ocular hypotensive lipids on clinically significant diabetic macular
edema.

Patel AS, Patel CC, Goyal A, Anchala A, Adrean S, Hughes B, Mahmoud TH.

Kresge Eye Institute, Department of Ophthalmology, Wayne State University School
of Medicine, Detroit, Michigan - USA.

Purpose. To study the impact of ocular hypotensive lipids (OHL) on the
incidence, progression, and response to treatment of clinically significant
diabetic macular edema (CSDME). Methods. A total of 379 patients (232 female,
147 male) with a history of diabetes mellitus (DM) and primary open-angle
glaucoma (POAG) were identified and included in the study. Patients were
stratified into groups based on CSDME development and OHL exposure. Main outcome
measures included time to development of CSDME, total duration of OHL exposure,
and duration of DM and POAG. Results. Seven patients (1.8%) developed CSDME
after OHL exposure (group 1A), 15 (4.0%) developed CSDME prior to OHL exposure
(group 1B), and 197 (52.0%) were treated with OHL but never developed CSDME
(group 2). Of patients not exposed to OHL, 22 (5.8%) developed CSDME (group 3)
and 138 (36.4%) did not (group 4). Mean duration of DM was longer (p<0.0001) in
patients who developed CSDME (20.2 years) compared to patients who did not (12.4
years). There was no difference (p=0.67) in the amount of OHL exposure between
patients who developed CSDME (4.1 years) and patients who did not (4.6 years).
Once developed, there was no difference in the interval until CSDME resolution
between OHL treated (17.8 mo) and untreated (12.7 mo) patients (p=0.36).
Conclusions. The CSDME development correlated most strongly with the duration of
diabetes, irrespective of OHL use. Ocular hypotensive lipids treatment of POAG
seems not to affect the incidence, progression, or response to treatment of
CSDME in diabetes.

PMID: 22267460  [PubMed - as supplied by publisher]

11: Eur J Ophthalmol. 2012 Jan 13;:0 [Epub ahead of print] 

Pentacam sensitivity and specificity in detecting occludable angles.

Rossi GC, Scudeller L, Delfino A, Raimondi M, Pezzotta S, Maccarone M,
Antoniazzi E, Pasinetti GM, Bianchi PE.

University Eye Clinic of Pavia, IRCCS Policlinico San Matteo Foundation, Pavia -
Italy.

Purpose. To assess the sensitivity and specificity of Pentacam measurements in
detection of occludable angles and to provide cutoff values. Methods.
Observational, single-center, cross-sectional study on 64 Caucasian eyes: 28
(43.7%) primary narrow angles or primary angle-closure glaucoma, and 36 (56.2%)
controls: all subjects were evaluated and classified by gonioscopy (Shaffer
classification). The following measurements have been considered: superior and
inferior anterior chamber angle (ACA), temporal and nasal ACA, anterior chamber
depth (ACD) using 5 value representation (central, superior, inferior, nasal,
temporal), and anterior chamber volume (ACV). Validity of Pentacam parameters to
detect patients in Shaffer 0 or I class was assessed by receiver operating
characteristic (ROC) curves analysis; cutoffs were chosen as to maximize
sensitivity and specificity. Results. All the considered Pentacam measures were
statistically different between the 2 groups (p<0.0001). All Shaffer grade
groups differed in all parameters (p<0.001), except for grade 0 and I, which did
not differ in any. Area under the curve ROC analysis revealed high discriminant
power of all Pentacam measures: ACA = 0.94; ACD = 0.91; ACD central = 0.89; and
ACV = 0.89. Chosen cutoff values (ACA = 22.4 degrees ; ACD = 1.12 mm; ACD
central = 1.93 mm; ACV = 84 mm3) allowed correct classification of narrow
angles. Conclusions. The study pointed out a high power of Pentacam AVA, ACV,
and ACD in detecting occludable angles. Pentacam is simple to use, reliable, and
noncontact, provides parameters in a short period, and represents a possible
screening tool.

PMID: 22267459  [PubMed - as supplied by publisher]

12: Eur J Ophthalmol. 2012 Jan 16;:0 [Epub ahead of print] 

Tonography assessment using quantitative and qualitative analysis of the aqueous
humor outflow mechanism.

Kozobolis VP, Paschalis EI, Labiris G, Foudoulakis NC, Konstantinidis A,
Koukoula SC.

Department of Ophthalmology and Eye Institute of Thrace, Democritus University
of Thrace, Alexandroupolis - Greece.

Purpose. To perform qualitative evaluation of the aqueous humor (AH) outflow
mechanism in glaucoma and nonglaucoma patients by means of tonography assessment
and mathematical analysis. Methods. Sixty-two primary open angle and 58
pseudoexfoliation glaucoma patients were recruited in a non-interventional,
observational study between 2004 and 2007. Qualitative and quantitative outflow
assessment was acquired by means of a digital tonographer and mathematical
analysis. Qualitative results were represented using slope analysis of the
change of the AH outflow rate over the tonography study. The results were
compared to the control group (CG; n=100) as well as to a pseudoexfoliation
group (PEX; n=46). Results. Regarding quantitative analysis, glaucoma groups
exhibited significantly lower outflow facility compared to nonglaucoma ones
(p<0.001). Outflow facility value was significantly correlated to cup to disc
ratio (Pearson correlation r=-0.3, p<0.001). Regarding qualitative analysis, the
primary open-angle glaucoma (POAG) group presented a significant profile
variation at the beginning of the tonography, expressed as an increased
resistance of the AH outflow. Both glaucoma groups exhibited profile
stabilization at the end of the measurement, suggesting that the outflow rate
remained constant, while nonglaucoma groups followed a continuous reduction of
the AH outflow rate throughout the study. Conclusions. The POAG, PXG, PEX, and
CG groups demonstrated both qualitative and quantitative tonographic profile
differences. The observed differences in the glaucoma groups suggest a distinct
pathomechanism between POAG and PXG. It is suggested that POAG patients have a
temporary disruption of the AH flow pathway, while PXG patients have a
generalized increased flow resistance.

PMID: 22267458  [PubMed - as supplied by publisher]

13: Eur J Ophthalmol. 2012 Jan 16;:0 [Epub ahead of print] 

Femtosecond laser photodisruptive effects on the posterior human corneal stroma
investigated with atomic force microscopy.

Serrao S, Lombardo M, De Santo MP, Lombardo G, Schiano Lomoriello D, Ducoli P,
Stirpe M.

IRCCS Fondazione G.B. Bietti, Rome - Italy.

Purpose. To analyze the effects of femtosecond laser pulses on the posterior
human corneal stroma with atomic force microscopy (AFM) and environmental
scanning electron microscopy (ESEM). Methods. A femtosecond laser (IntraLase
iFS, Abbott, USA) was programmed to create a full posterior lamellar dissection
in 9 human corneal tissues, using 3 different pulse energies (1.00 microJ, 0.75
microJ, and 0.50 microJ). Three corneal tissues were prepared in a similar
fashion using a mechanical microkeratome (Moria Evolution 3, Moria, France). Six
corneal tissues received an 8.00-mm diameter full cylindrical resection using
either the femtosecond laser or the Barron trephine (Katena Products Inc., USA).
The posterior corneal lenticules were first examined at AFM (Autoprobe CP,
Veeco, USA). Both the posterior lenticules and the trephined corneal samples
were scanned by ESEM (FEI Quanta 400, USA). Results. Granules and crater-like
features were observed on the stromal interface of all the laser dissected
tissues, likely due to a secondary thermal effect of femtosecond laser
dissection. Collagen fibers were seen only on samples treated with the 0.50
microJ pulse energy. Images of an even stromal surface were observed on the
posterior stroma of mechanically dissected corneal samples. Conclusions.
Mechanical and thermal effects, induced by femtosecond laser pulses on the human
corneal stroma, were seen with AFM. Surface regularity of the photodisrupted
stroma was inversely and non-linearly related to the pulse energy. The
femtosecond laser provided high surface quality for lamellar resection of the
posterior stroma comparable to those provided by mechanical devices.

PMID: 22267457  [PubMed - as supplied by publisher]

14: Eur J Ophthalmol. 2012 Jan 17;:0 [Epub ahead of print] 

Riboflavin's time-dependent degradation rate induced by ultraviolet A
irradiation.

Diakonis VF, Grentzelos MA, Tzatzarakis MN, Kankaria V, Karavitaki A,
Karatapanis AE, Tsatsakis AM, Kymionis GD.

Institute of Vision and Optics, Department of Medicine, University of Crete,
Heraklion - Greece.

Purpose. To evaluate the time-dependent degradation rate of riboflavin after
ultraviolet A (UVA) irradiation. Methods. Two solutions of commercially
available riboflavin solution (0.1%) were used; one served as control, while the
second was irradiated using UVA light at 370 nm wavelength. Four samples of
riboflavin solution were retrieved prior to irradiance and at 1, 5, 15, 30, and
60 minutes after irradiation (group A); at the same time points samples of
riboflavin were retrieved from the control solution in order to assess
environmental time-induced degradation of riboflavin (group B). All samples were
immediately analyzed using liquid chromatograph mass spectrometry to detect
riboflavin and its 2 subproducts, lumiflavin (LF) and lumichrome (LC). Results.
Mean percentage of riboflavin degradation was 0.0, 5.3, 9.1, 15.3, 20.6, and
33.3 at 0, 1, 5, 15, 30, and 60 minutes after UVA irradiation, respectively
(group A). The time-dependent riboflavin degradation was statistically
significant (p<0.05), while for group B there was no change in riboflavin
concentration at all time intervals. In group A, mean LC concentration
demonstrated a gradual concentration increase, reaching 2.386+/-1.526 ppm after
60 minutes of UVA exposure. Conclusions. The time-dependent degradation of
riboflavin solution is significant, reaching 20.6% after 30 minutes of UVA
exposure. It seems that only a small fraction of the overall riboflavin
molecules break down since more than 65% remain intact even after 1 hour of UVA
irradiation. Control riboflavin solution seems to be stable, as no degradation
is evident even after 60 minutes.

PMID: 22267456  [PubMed - as supplied by publisher]

15: Eur J Ophthalmol. 2012 Jan 13;:0 [Epub ahead of print] 

Controlled clinical trial comparing biaxial microincision with coaxial small
incision for cataract surgery.

Dick HB.

Institute of Vision Science, Ruhr University, Bochum - Germany.

Purpose. Clinical outcomes of biaxial microincision versus coaxial small
incision cataract surgery were compared in a prospective, controlled, paired-eye
clinical study. Methods. A total of 84 eyes of 42 patients underwent cataract
surgery using the biaxial microincision (B-MICS) technique in either the right
or left eye. The fellow eye was to undergo cataract surgery using the standard
coaxial small incision (SICS) technique. All surgeries were performed using the
Stellaris Vision Enhancement System and all eyes were implanted with an aspheric
microincision intraocular lens (IOL). The 1.2-mm B-MICS incision was widened to
1.8 mm for IOL insertion. The main outcome measure was the change from baseline
best-corrected visual acuity (BCVA). Secondary outcome measures were uncorrected
visual acuity (UCVA), surgically induced astigmatism (SIA), manifest subjective
refraction in spherical equivalent (MRSE), absolute phacoemulsification time
(APT), effective phacoemulsification time (EPT), mean phacoemulsification power,
and endothelial cell count (ECC). Follow-up was at 1 day, 3 days, 1 week, and 2
months. Results. The treatment groups did not differ in baseline
characteristics. Improvement in BCVA over baseline logarithm of the minimum
angle of resolution (logMAR) was statistically significantly greater with B-MICS
than SICS at 1 day (B-MICS -0.1, SICS -0.05; 95% CI -0.26 to -0.05, p=0.005).
Mean improvement in UCVA from baseline was greater with B-MICS at 1 day (B-MICS
-0.33, SICS -0.12; 95% CI -0.35 to -0.10, p=0.001), 3 days (B-MICS -0.39, SICS
-0.26; 95% CI -0.22 to -0.02, p=0.022), 1 week (B-MICS -0.44, SICS -0.33; 95% CI
-0.20 to -0.009, p=0.033), and 2 months (B-MICS -0.47, SICS 0.38; 95% CI -0.19
to +0.002, p =0.054). At 2 months, SIA was significantly lower with B-MICS than
SICS (B-MICS 0.70 D, SICS 0.89 D; 95% CI -0.39 to -0.1, p=0.045), as was
endothelial cell loss (B-MICS -1.4%, SICS -7.8%; p=0.05). The EPT was lower with
B-MICS (B-MICS 1.60 s, SICS 2.80 s; 95% CI -1.68 to -0.77, p<0.001) with no
difference in mean phaco power. Conclusions. Compared to the standard small
incision technique, B-MICS showed earlier improvement in BCVA, better overall
UCVA, less SIA, and less endothelial cell loss.

PMID: 22267455  [PubMed - as supplied by publisher]

16: Eur J Ophthalmol. 2012 Jan 3;:0 [Epub ahead of print] 

Pediatric ocular rosacea: 2 cases.

Miguel AI, Salgado MB, Lisboa MS, Henriques F, Paiva MC, Castela GP.

Department of Ophthalmology, Centro Hospitalar de Coimbra, Coimbra - Portugal.

Purpose. To report the clinical course of 2 pediatric ocular rosacea cases with
a significant delay until diagnosis. Methods. We report 2 interventional case
reports. Case 1 is a 10-year-old boy with 2 years of recurrent bilateral
blepharitis, repetition chalazion, conjunctival hyperemia, and corneal ulcers,
without response to topical antibiotics or topical and systemic steroids. Case 2
is a 9-year-old girl with keratoconjunctivitis and repetition chalazion since
she was 2 years old, without improvement after consulting several
ophthalmologists and performing several treatments throughout those years.
Results. Rapid response to systemic erythromycin with marked improvement of both
cases within a few weeks. Conclusions. Ocular rosacea is frequently
misdiagnosed, particularly in the pediatric population. To our knowledge, this
report demonstrates a case with the longest history before diagnosis (7 years)
and another case in which a conjunctival biopsy was performed.

PMID: 22267454  [PubMed - as supplied by publisher]

17: Eur J Ophthalmol. 2011 Dec 23;:0 [Epub ahead of print] 

Repeatability and agreement of 2 Scheimpflug analyzers in measuring the central
corneal thickness and anterior chamber angle, volume, and depth.

Bedei A, Appolloni I, Madesani A, Pietrelli A, Franceschi S, Barabesi L.

H.M.O. "San Camillo", Forte dei Marmi - Italy.

Purpose. To evaluate the repeatability and agreement of 2 Scheimpflug
tomographies (Pentacam HR, Oculus GmbH; Sirius, CSO Inc.) in measuring the
central corneal thickness (CCT) and depth (ACD), volume (ACV), and angle (ACA)
of the anterior chamber. Methods. Three consecutive measurements were performed
in one eye of each subject, with both instruments. The following were evaluated:
CCT, ACD, ACV, and ACA. Repeatability was assessed by the Friedman test and
agreement was assessed by 4 different Wilcoxon tests for paired data. Results.
The study enrolled 30 patients. With Sirius tomography the Friedman test p
values for testing homogeneity across measurements was with respect to CCT
0.320, ACD 0.315, ACV 0.171, and ACA 0.020; and with Pentacam CCT 0.191, ACD
0.010, ACV 0.704, and ACA 0.150. The Wilcoxon test p values for testing the
measurement homogeneity between the corneal tomography Sirius and Pentacam
showed the following: ACD 0.000, ACD 0.000, ACV 0.853, and ACA 0.000.
Conclusions. The measurements may be considered substantially stable for each
corneal tomography and each variable, but the 2 corneal tomographies do not
produce statistically equivalent measurements.

PMID: 22267453  [PubMed - as supplied by publisher]

18: Eur J Ophthalmol. 2011 Dec 20;:0 [Epub ahead of print] 

Isolated transient blindness and isolated oculomotor nerve palsy secondary to
single mesencephalic metastases: report of 2 cases.

Rotondo M, Lus G, Scuotto A.

Neurosurgery, Department of Neurological Sciences, Second University of Naples,
Naples - Italy.

Purpose. Metastatic lesions of midbrain are quite rare, and only unusually they
produce isolated cranial nerve palsy. Methods. We report two cases of 2nd and
3rd cranial nerves impairment, produced by solitary midbrain metastases. In both
patients Magnetic Resonance (MR) allowed a correct diagnosis, subsequently
confirmed by histology. Results and Conclusions. The metastatic involvement of
midbrain would be included in the differential diagnosis of neuro-ophthalmic
conditions to avoid the risk of misdiagnosis and consequently delay in
management of this special population. MR is crucial for early detection of this
infrequent pathology.

PMID: 22267452  [PubMed - as supplied by publisher]

19: Eur J Ophthalmol. 2011 Dec 23;:0 [Epub ahead of print] 

Endogenous endophthalmitis with an unusual infective agent: Actinomyces neuii.

Graffi S, Peretz A, Naftali M.

Department of Ophthalmology, Bruch Padeh Medical Center, Poriya - Israel.

Purpose. To report an unusual case of a patient with endogenous endophthalmitis
caused by Actinomyces neuii. Methods and Results. A 69-year-old woman in an
immunosuppressed state and who had a previous history of periappendicular
abscess presented with bilateral red painful eyes. The diagnosis was confirmed
by culture and pan-bacterial polymerase chain reaction drawn from anterior
chamber sample. On admission, the patient underwent an intravitreal injection of
vancomycin combined with ceftazidime. Following a 3-week treatment of
intravenous penicillin and topical sulfacetamide sodium, the patient recovered
fully. Conclusions. Actinomyces neuii can cause endogenous endophthalmitis.
Intravenous penicillin G is an effective treatment leading to favorable
prognosis.

PMID: 22267451  [PubMed - as supplied by publisher]