Journal Contents

Am Jour Ophthalmol
Br J Ophthalmol
Can J Ophthalmol
J Cat Ref Surg
Cornea
Curr Eye Res
Eur J Ophthalmol
Eye
J Glaucoma
JAMA Ophthalmol
Graefes Ophthalmol
Indian J Ophthalmol
Int Ophthalmol Clin
Invest Ophth Vis Sci
Jpn J Ophthalmol
JPOS
Korean J Ophthal
J Neuroophthalmol
Ophthalmic Epidemiol
Ophthalmic Genet
Ophthal Plast Rec Surg
Ophthalmic Res
Ophthalmologica
Ophthalmology
Retina
Surv Ophthalmol
Ophthalmology Review Journal
Eye[JOUR] Established 1995
1. Eye (Lond). 2014 Aug 15. doi: 10.1038/eye.2014.176. [Epub ahead of print]

Optical quality of the diabetic eye: a review.

Calvo-Maroto AM(1), Perez-Cambrodí RJ(2), Albarán-Diego C(1), Pons A(1), Cerviño 
A(1).

Author information: 
(1)Optometry Research Group, Department of Optics, University of Valencia, Valencia,
Spain.
(2)Department of Ophthalmology, Oftalmar, Medimar International Hospital, Alicante, 
Spain.

Diabetes mellitus is a metabolic disorder characterized by the presence of
chronic hyperglycaemia. Several structural, morphological, and physiological
changes in each of ocular component have been described in detail during the past
decades. Due to these abnormalities, the diabetic patient undergoes a degradation
of the retinal image by an increase of higher ocular aberrations and ocular
scattering coming from mainly tear film, cornea, and crystalline lens. This
review aims to provide an overview of current knowledge about the effects of
diabetes mellitus in these optical phenomena and its consequence on the visual
quality of the diabetic patient.Eye advance online publication, 15 August 2014;
doi:10.1038/eye.2014.176.

PMID: 25125072   [PubMed - as supplied by publisher]


2. Eye (Lond). 2014 Aug 15. doi: 10.1038/eye.2014.200. [Epub ahead of print]

Posterior sclera reinforcement and phakic intraocular lens implantation for
highly myopic amblyopia in children: a 3-year follow-up.

Zhu SQ, Wang QM, Xue AQ, Zheng LY, Su YF, Yu AY.

Author information: 
The Eye Hospital of Wenzhou Medical University, Wenzhou, China.

PurposeTo study the safety and efficacy of posterior scleral reinforcement (PSR) 
combined with phakic intraocular lens (PIOLs) implantation for highly myopic
amblyopia in children.MethodsThis study included eight highly myopic children (11
eyes) who failed in conventional therapy for amblyopia using various combination 
of spectacles, contact lenses, and intensive patching before enrollment into this
study. They were treated sequentially with PSR and PIOL implantation, and were
followed up for 3 years after surgery. Uncorrected visual acuity (UCVA) and best 
corrected visual acuity (BCVA) in LogMAR, spherical equivalent power (SE), and
complications were evaluated.ResultsBefore surgery, the mean UCVA was 1.59±0.33, 
BCVA, 0.74±0.37, SE, -17.57±5.56D, the axial length (AL), 30.09±2.18 mm. After
PSR, BCVA improved one line in three patients, the rest were unchanged, and AL
was unchanged among all cases. Six eyes of three patients were implanted with an 
iris-claw PIOL and five eyes of five patients were implanted with a posterior
PIOL. After completion of treatment, the mean UCVA was 0.44±0.21, BCVA 0.38±0.24,
SE -0.54±0.74 D, and AL 30.35±2.29 mm. No patient experienced
complications.ConclusionCombined PSR and PIOL implantation treatment for highly
myopic amblyopia in children is safe and effective.Eye advance online
publication, 15 August 2014; doi:10.1038/eye.2014.200.

PMID: 25125071   [PubMed - as supplied by publisher]


3. Eye (Lond). 2014 Aug 15. doi: 10.1038/eye.2014.195. [Epub ahead of print]

Prevalence of glaucoma in patients with moderate to severe obstructive sleep
apnea: ocular morbidity and outcomes in a 3 year follow-up study.

Hashim SP(1), Al Mansouri FA(1), Farouk M(1), Al Hashemi AA(2), Singh R(3).

Author information: 
(1)Ophthalmology Section, Hamad Medical Corporation, Doha, Qatar.
(2)Pulmonary Division, Department of Medicine, Hamad Medical Corporation, Doha,
Qatar.
(3)Biostatitics Division, Department of Cardiology, Hamad Medical Corporation, Doha,
Qatar.

PurposeThis study was conducted to investigate the prevalence and progression of 
glaucoma in patients receiving treatment for obstructive sleep apnea (OSA). We
also investigated whether there is an association between severity of OSA and the
incidence of glaucoma.MethodsA total of 39 patients aged >30 years who had been
diagnosed with moderate and severe OSA in the sleep clinic at Hamad General
Hospital were assessed for the presence of glaucoma. The severity of OSA was
graded as mild, moderate, or severe based on American Association of Sleep
Medicine (AASM) criteria using the apnea hypopnea index. Before enrollment, all
patients underwent a complete ophthalmic examination including serial visual
field tests, optical coherence tomography (OCT) with fundus photographs, and
pachymetry. Enrolled patients were followed up in the ophthalmology outpatient
clinic and sleep clinic for a period of 3 years.ResultsExaminations found that 8 
(20.5%; 95% confidence interval (CI) 9.9-37%) of the 39 patients with OSA had
glaucoma. Six (75%; 95% CI 36-96%) of these patients had normal-tension glaucoma 
(NTG) and two (25%; 95% CI 4.5-64.4%) patients had high-tension glaucoma. Among
the 27 patients with severe OSA, 7 (25.9%; 95% CI 8-34%) had glaucoma, and among 
12 patients with moderate OSA, 1 (8.3%; 95% CI 0.1-15%) had glaucoma. During the 
course of follow-up, two patients who previously did not have glaucoma were
reclassified as NTG and two patients with glaucoma deteriorated. A higher
prevalence of glaucoma in the severe OSA group compared with the moderate OSA
group was found, albeit a statistically significant difference could not be
attained (P=0.4).ConclusionsOur study showed that severe OSA is an important risk
factor for developing glaucoma. Adequate treatment of OSA, along with optimal
ophthalmic care, resulted in better control of glaucoma.Eye advance online
publication, 15 August 2014; doi:10.1038/eye.2014.195.

PMID: 25125070   [PubMed - as supplied by publisher]


4. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.193. [Epub ahead of print]

Reply to 'Vitreoretinal surgery for inadvertent intralenticular Ozurdex implant'

Chhabra R, Mahmood S.

Author information: 
Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, UK.

PMID: 25104747   [PubMed - as supplied by publisher]


5. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.183. [Epub ahead of print]

Pedicled lower lid-sharing flap for full-thickness reconstruction of the upper
eyelid.

Wang YC, Dai HY, Xing X, Lv C, Zhu J, Xue CY.

Author information: 
Department of Plastic Surgery, Changhai Hospital, Second Military Medical
University, Shanghai, China.

PurposeTo explore the clinical effect of the pedicled lower lid-sharing flap for 
full-thickness reconstruction of the upper eyelid.MethodsFrom 2009 to 2013, 13
upper eyelids with meibomian gland carcinoma (13 patients, age range 52-78 years)
were excised, and immediately reconstructed with a pedicled lower lid-sharing
flap used for full-thickness upper eyelid defects (up to two-thirds of the eyelid
width). Traditionally, the flap is divided after 3 to 4 weeks, and the recipient 
site closed directly.ResultsDuring a 1-18-month follow-up period, no recurrence, 
lagophthalmos, hypertrophic scar, or bulky appearance was noted in any of the
patients. Aesthetic results for the upper eyelid were obtained for all
patients.ConclusionsWe conclude that the pedicled lower lid-sharing flap is a
safe and reliable method for reconstruction of full-thickness upper eyelid
defects. This procedure not only enables eyelid closure for eye protection, but
also directly improves the aesthetic appearance of the face. After second-stage
surgery, a stable eyelid margin and lashes with good blood supply and an
acceptable cosmetic appearance with regard to symmetry of eyelid height, contour,
tarsal show, and skin fold were achieved.Eye advance online publication, 8 August
2014; doi:10.1038/eye.2014.183.

PMID: 25104746   [PubMed - as supplied by publisher]


6. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.177. [Epub ahead of print]

Ocular surface foreign bodies: novel findings mimicking ocular malignant
melanoma.

Maudgil A(1), Wagner BE(2), Rundle P(1), Rennie IG(3), Mudhar HS(4).

Author information: 
(1)Department of Ophthalmology, Royal Hallamshire Hospital , Sheffield, UK.
(2)Electron Microscopy Unit, Department of Histopathology, Royal Hallamshire
Hospital, Sheffield, UK.
(3)Academic Unit of Ophthalmology & Orthoptics, The University of Sheffield,
Sheffield, UK.
(4)National Specialist Ophthalmic Pathology Service (NSOPS)-Department of
Histopathology, Royal Hallamshire Hospital, Sheffield, UK.

PurposeMalignant melanoma of the eye is an uncommon condition that is important
to recognise. We describe three cases in which ocular foreign bodies have
masqueraded as ocular malignant melanoma.MethodsInterventional case
reports.ResultsCase 1 describes diathermy-induced carbon particle implantation,
during plaque therapy for the treatment of uveal melanoma, mimicking recurrence
with extra-scleral invasion. Case 2 shows a foreign body called 'mullite'
mimicking conjunctival melanoma. Case 3 demonstrates a conjunctival foreign body 
called 'illite' that mimicked a limbal melanocytic lesion, clinically thought to 
be either melanocytoma or melanoma.ConclusionThis report highlights the
importance of careful history taking, examination, and appropriate biopsy in
cases of suspected malignant melanoma, to prevent unnecessary and potentially
radical treatment.Eye advance online publication, 8 August 2014;
doi:10.1038/eye.2014.177.

PMID: 25104745   [PubMed - as supplied by publisher]


7. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.182. [Epub ahead of print]

Longitudinal comparison of visual acuity as measured by the ETDRS chart and by
the potential acuity meter in eyes with macular edema, and its relationship with 
retinal thickness and sensitivity.

Hatef E(1), Hanout M(2), Moradi A(3), Colantuoni E(4), Bittencourt M(3), Liu
H(3), Sepah YJ(2), Ibrahim M(3), Do DV(5), Guyton DL(3), Nguyen QD(5).

Author information: 
(1)1] Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD, USA [2] General Preventive Medicine, Johns
Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
(2)1] Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns
Hopkins University, Baltimore, MD, USA [2] Ocular Imaging Research and Reading
Center, Stanley M. Truhlsen Eye Institute, University of Nebraska Medical Center,
Omaha, NE, USA.
(3)Retinal Imaging Research and Reading Center, Wilmer Eye Institute, Johns Hopkins 
University, Baltimore, MD, USA.
(4)Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins
University, Baltimore, MD, USA.
(5)Ocular Imaging Research and Reading Center, Stanley M. Truhlsen Eye Institute,
University of Nebraska Medical Center, Omaha, NE, USA.

PurposeTo evaluate the relationship between visual acuity as measured by the
Early Treatment Diabetic Retinopathy Study (ETDRS) chart and by the potential
acuity meter (PAM) with retinal thickness and sensitivity measured by a combined 
microperimetry/optical coherence tomography system (OCT).MethodsForty-four
patients with macular edema (ME) were included in a prospective observational
study. Visual acuity (VA) was assessed using the ETDRS chart (with best
correction) as well as by the PAM. Retinal thickness and sensitivity was measured
by an automatic fundus perimetry/tomography system.ResultsBest-corrected VA using
the ETDRS chart ranged from 20/20 to 20/400 (median: 20/50). VA measured by the
PAM without correction ranged from 20/20 to 20/400 (median: 20/40). The mean
retinal thickness was 369.57 μm (s.d.: 140.28 μm) on spectral domain-OCT and the 
mean retinal sensitivity was 8.12 decibels (dB) (s.d.: 5.78 dB). The mean LogMAR 
value using the ETDRS chart was 0.43, whereas it was 0.38 using the PAM (P-value:
0.009).ConclusionsVA values measured by the PAM were statistically significantly 
better than those measured by the ETDRS chart in eyes with ME secondary to
various retinal vascular and uveitic diseases. VA measured by the PAM may be a
more sensitive predictor of macular function than that obtained by ETDRS testing 
in eyes with ME.Eye advance online publication, 8 August 2014;
doi:10.1038/eye.2014.182.

PMID: 25104744   [PubMed - as supplied by publisher]


8. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.192. [Epub ahead of print]

Vitreoretinal surgery for inadvertent intralenticular Ozurdex implant.

Chalioulias K(1), Muqit MM(2).

Author information: 
(1)Vitreoretinal Service, Moorfields Eye Hospital, London, UK.
(2)1] Vitreoretinal Service, Moorfields Eye Hospital, London, UK [2] Institute of
Ophthalmology, University College London, London, UK.

PMID: 25104743   [PubMed - as supplied by publisher]


9. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.188. [Epub ahead of print]

Efficacy and safety of a new surgical method to treat malignant glaucoma in
pseudophakia: reply.

Zarnowski T(1), Rękas M(2).

Author information: 
(1)Department of Diagnostics and Microsurgery of Glaucoma, Medical University,
Lublin, Poland.
(2)Department of Ophthalmology, Military Institute of Medicine, Warsaw, Poland.

PMID: 25104742   [PubMed - as supplied by publisher]


10. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.190. [Epub ahead of print]

Transient retinal artery occlusion during phacoemulsification cataract surgery.

Yusuf IH, Fung TH, Wasik M, Patel CK.

Author information: 
The Oxford Eye Hospital, West Wing, John Radcliffe Hospital, Oxford, UK.

PurposeTransient retinal artery occlusion (TRAO) is a potentially underdiagnosed 
cause of immediate 'pad off' visual loss following phacoemulsification cataract
surgery under sub-Tenon's anaesthesia.MethodsWe describe a series of three
patients presenting with enigmatic 'pad off' visual loss following
phacoemulsification surgery, each diagnosed with TRAO. We describe the variable
clinical presentation, illustrate the value of optical coherence tomography (OCT)
imaging in establishing the diagnosis, and present the final visual
outcomes.ResultsClinical findings alone may be subtle and inadequate in
localising the pathology in patients with TRAO. Cross-comparison of superior and 
inferior macula OCT profiles in branch-pattern arterial occlusion-and between
healthy and affected eyes in central-pattern arteriolar occlusion-is critical in 
clinching the diagnosis. The typical evolution of OCT appearance is acute-phase
inner retinal thickening/oedema and hyperreflectivity followed by progressive,
late-phase inner retinal atrophy. Visual acuity may recover but central scotomas,
and defects in colour perception may persist.ConclusionThe diagnosis of TRAO is
challenging; delayed presentation may resolve fundal and retinal angiographic
abnormalities. OCT may be the only imaging modality that can provide objective
evidence of TRAO. Meticulous comparison/segmentation of OCT images is therefore
mandatory in patients presenting with acute post-operative visual loss to exclude
TRAO.Eye advance online publication, 8 August 2014; doi:10.1038/eye.2014.190.

PMID: 25104741   [PubMed - as supplied by publisher]


11. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.173. [Epub ahead of print]

Sterile keratitis after combined riboflavin-UVA corneal collagen cross-linking
for keratoconus.

Lam FC, Geourgoudis P, Nanavaty MA, Khan S, Lake D.

Author information: 
The Corneoplastic Unit, Queen Victoria Hospital, West Sussex, UK.

PurposeTo investigate patient risk factors and to look for potential causes of
sterile infiltrates following an unexpected cluster of sterile keratitis after a 
routine collagen cross-linking (CXL) list.MethodsThe records of all 148 cases of 
CXL were reviewed retrospectively. The equipment and solutions used and our
clinic's standard operating procedure for CXL were reviewed. An in-vitro
experiment to explore the variation in ultraviolet A (UVA) irradiance from
fluctuations in the working distance of the UVA lamp was conducted.ResultsThe
four patients who developed sterile infiltrates had steeper maximum corneal
curvatures (68.0±7.3 D) and thinner pachymetry (389.9±49.0 μm) than the 144 who
did not (57.0±8.2 D, P=0.05; 454.6±45.4 μm, P=0.08). A corneal curvature of
>60 Dand a pachymetry of <425 μm were significant risk factors. All four affected
cases obtained a complete resolution with topical antibiotics and steroids. The
unaided VA and the maximum K improved from their pre-operative levels in three
out of four patients. A 2-mm reduction in distance of the VEGA C.B.M. X-Linker
from a treated surface increased irradiance to 3.5-3.7 mW/cm(2), which is above
the threshold for endothelial toxicity.ConclusionPatients with thinner and
steeper corneas are at an increased risk of developing sterile keratitis. The
visual outcomes despite this complication are good.Eye advance online
publication, 8 August 2014; doi:10.1038/eye.2014.173.

PMID: 25104740   [PubMed - as supplied by publisher]


12. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.198. [Epub ahead of print]

Comment on 'Intrasilicone oil injection of bevacizumab at the end of retinal
reattachment surgery for severe proliferative vitreoretinopathy'

Radke NV(1), Panakanti TK(2), Radke SN(1), Ravikoti R(2).

Author information: 
(1)Department of Vitreo-Retina, Dr. Agarwal's Eye Hospital, Kigali, Rwanda.
(2)Department of Vitreo-Retina, Vasan Eye Care Hospital, Hyderabad, India.

PMID: 25104739   [PubMed - as supplied by publisher]


13. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.187. [Epub ahead of print]

Regarding 'efficacy and safety of a new surgical method to treat malignant
glaucoma in pseudophakia'

Morgan WH.

Author information: 
Lions Eye Institute, University of Western Australia, Nedlands, Western
Australia, Australia.

PMID: 25104738   [PubMed - as supplied by publisher]


14. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.199. [Epub ahead of print]

Proliferative vitreoretinopathy and antivascular endothelial growth factor
treatment.

Ghasemi Falavarjani K, Modarres M.

Author information: 
Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences,
Tehran, Iran.

PMID: 25104737   [PubMed - as supplied by publisher]


15. Eye (Lond). 2014 Aug 8. doi: 10.1038/eye.2014.172. [Epub ahead of print]

Refractive errors after the use of bevacizumab for the treatment of retinopathy
of prematurity: 2-year outcomes.

Chen YH(1), Chen SN(2), Lien RI(3), Shih CP(4), Chao AN(1), Chen KJ(1), Hwang
YS(1), Wang NK(1), Chen YP(1), Lee KH(5), Chuang CC(5), Chen TL(1), Lai CC(1), Wu
WC(1); Medscape.

Author information: 
(1)1] Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan [2]
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
(2)1] Department of Ophthalmology, Chang-Hua Christian Hospital, Chang-Hua city,
Taiwan [2] School of Medicine, Chung Shan Medical University.
(3)1] College of Medicine, Chang Gung University, Taoyuan, Taiwan [2] Department of 
Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
(4)Department of Business Administration, Chang Gung University, Taoyuan, Taiwan.
(5)Department of Ophthalmology, Chang-Hua Christian Hospital, Chang-Hua city,
Taiwan.

PurposeTo evaluate the refractive outcomes in children treated after intravitreal
injection of bevacizumab (IVB) for retinopathy of prematurity (ROP).MethodsA
retrospective, bi-centre study of 34 patients (64 eyes) was conducted. The
patients were divided into three groups, patients received intravitreal IVB (IVB 
group), patients received combined IVB and laser treatment (IVB+Laser group), or 
patients received lens-sparing vitrectomy (IVB+LSV group). Cycloplegic refraction
and axial length (AXL) were evaluated at 2 years old.ResultsThe prevalences of
myopia and high myopia were 47.5 and 10.0% in the IVB group, respectively, which 
were lower than those in the IVB+Laser (82.4 and 29.4%) and IVB+LSV (all 100%)
groups (P=0.001 and P<0.001). The prevalences of emmetropia in the IVB group,
IVB+Laser group, and IVB+LSV group were 50, 5.9, and 0% (P=0.001). The AXL were
similar among all groups.ConclusionsAt the 2-year follow-up, severe ROP patients 
treated with IVB alone were more likely to remain emmetropic and had lower
prevalences of myopia and high myopia. The development of high myopia in severe
ROP patients could not be explained by AXL changes but may be associated with
abnormalities in the anterior segment.Eye advance online publication, 8 August
2014; doi:10.1038/eye.2014.172.

PMID: 25104736   [PubMed - as supplied by publisher]


16. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.175. [Epub ahead of print]

Calcification of Rayner hydrophilic acrylic intra-ocular lenses after Descemet's 
stripping automated endothelial keratoplasty.

De Cock R, Fajgenbaum MA.

Author information: 
Kent and Canterbury Hospital, East Kent Hospitals University Trust, Canterbury,
UK.

PMID: 25081295   [PubMed - as supplied by publisher]


17. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.189. [Epub ahead of print]

Visual function assessment in simulated real-life situations in patients with
age-related macular degeneration compared to normal subjects.

Barteselli G(1), Gomez ML(2), Doede AL(2), Chhablani J(3), Gutstein W(4), Bartsch
DU(2), Dustin L(5), Azen SP(5), Freeman WR(2).

Author information: 
(1)1] Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Center,
University of California, San Diego, La Jolla, CA, USA [2] Ophthalmological Unit,
Department of Clinical Sciences and Community Health, Ca' Granda
Foundation-Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.
(2)Department of Ophthalmology, Jacobs Retina Center at Shiley Eye Center,
University of California, San Diego, La Jolla, CA, USA.
(3)L V Prasad Eye Institute, Hyderabad, India.
(4)Salus University, Elkins Park, PA, USA.
(5)Department of Preventive Medicine, Keck School of Medicine, University of
Southern California, Los Angeles, CA, USA.

PurposeTo evaluate visual function variations in eyes with age-related macular
degeneration (AMD) compared to normal eyes under different light/contrast
conditions using a time-dependent visual acuity testing instrument, the Central
Vision Analyzer (CVA).MethodsOverall, 37 AMD eyes and 35 normal eyes were
consecutively tested with the CVA after assessing best-corrected visual acuity
(BCVA) using ETDRS charts. The CVA established visual thresholds for three
mesopic environments (M1 (high contrast), M2 (medium contrast), and M3 (low
contrast)) and three backlight-glare environments (G1 (high contrast, equivalent 
to ETDRS), G2 (medium contrast), and G3 (low contrast)) under timed conditions.
Vision drop across environments was calculated, and repeatability of visual
scores was determined.ResultsBCVA significantly reduced with decreasing contrast 
in all eyes. M1 scores for BCVA were greater than M2 and M3 (P<0.001); G1 scores 
were greater than G2 and G3 (P<0.01). BCVA dropped more in AMD eyes than in
normal eyes between M1 and M2 (P=0.002) and between M1 and M3 (P=0.003). In AMD
eyes, BCVA was better using ETDRS charts compared to G1 (P<0.001). The drop in
visual function between ETDRS and G1 was greater in AMD eyes compared to normal
eyes (P=0.004). Standard deviations of test-retest ranged from 0.100 to 0.139
logMAR.ConclusionThe CVA allowed analysis of the visual complaints that AMD
patients experience with different lighting/contrast time-dependent conditions.
BCVA changed significantly under different lighting/contrast conditions in all
eyes, however, AMD eyes were more affected by contrast reduction than normal
eyes. In AMD eyes, timed conditions using the CVA led to worse BCVA compared to
non-timed ETDRS charts.Eye advance online publication, 1 August 2014;
doi:10.1038/eye.2014.189.

PMID: 25081294   [PubMed - as supplied by publisher]


18. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.160. [Epub ahead of print]

Treating maculopathy at the expense of proliferative disease: an emerging problem
in 'macular treatment centres'

Mookhtiar MA, Carrim ZI.

Author information: 
Department of Ophthalmology, St James's University Hospital, Leeds, UK.

PMID: 25081293   [PubMed - as supplied by publisher]


19. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.191. [Epub ahead of print]

Choroidal thickness alterations in obstructive sleep apnea-hypopnea syndrome
(OSAS).

Bayhan HA, Aslan Bayhan S.

Author information: 
Ophthalmology Department, Bozok University Faculty of Medicine, Yozgat, Turkey.

PMID: 25081292   [PubMed - as supplied by publisher]


20. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.181. [Epub ahead of print]

Transient visual loss due to reversible 'pending' central retinal artery
occlusion in occult giant cell arteritis.

Sane M(1), Selvadurai A(2), Reidy J(1), Higgs D(3), Gonzalez-Fernandez F(4),
Lincoff N(5).

Author information: 
(1)Department of Ophthalmology, University at Buffalo, the State University of New
York, Buffalo, NY, USA.
(2)Veterans Affairs Medical Center, Buffalo, NY, USA.
(3)Department of Pathology and Anatomic Sciences, University at Buffalo, the State
University of New York, Buffalo, NY, USA.
(4)1] Department of Ophthalmology, University at Buffalo, the State University of
New York, Buffalo, NY, USA [2] Veterans Affairs Medical Center, Buffalo, NY, USA 
[3] Department of Pathology and Anatomic Sciences, University at Buffalo, the
State University of New York, Buffalo, NY, USA.
(5)Jacobs Neurological Institute, Buffalo, NY, USA.

PMID: 25081291   [PubMed - as supplied by publisher]


21. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.180. [Epub ahead of print]

Short-term intraocular pressure trends following intravitreal ranibizumab
injections for neovascular age-related macular degeneration-the role of oral
acetazolamide in protecting glaucoma patients.

Murray CD, Wood D, Allgar V, Walters G, Gale RP.

Author information: 
Academic Unit of Ophthalmology, York Teaching Hospital NHS Foundation Trust,
York, UK.

PurposeTo determine the effect of oral acetazolamide on lowering the peak and
duration of intraocular pressure (IOP) rise in glaucoma and glaucoma suspect
patients, following intravitreal injection of ranibizumab for neovascular
age-related macular degeneration.MethodsThe study was an open-label, parallel,
randomised, controlled trial (EudraCT Number: 2010-023037-35). Twenty-four
glaucoma or glaucoma suspect patients received either 500 mg acetazolamide or no 
treatment 60-90 min before 0.5 mg ranibizumab. The primary outcome measure was
the difference in IOP immediately after injection (T0) and 5, 10, and 30 min
following injection. ANCOVA was used to compare groups, adjusting for baseline
IOP. The study was powered to detect a 9-mm Hg difference at T0.ResultsThe IOP at
T0 was 2.3 mm Hg higher in the non-treated group (mean 44.5 mm Hg, range
(19-86 mm Hg)) compared with the treated group (mean 42.2 mm Hg, range
(25-58 mm Hg)), but was not statistically significant after adjusting for
baseline IOP (P=0.440). At 30 min, IOP was 4.9 mm Hg higher in the non-treated
group (mean 20.6 mm Hg, range (11-46 mm Hg)) compared with the treated group
(mean 15.7 mm Hg, range (8-21 mm Hg)). This was statistically significant after
adjusting for baseline IOP (P=0.013).ConclusionsAlthough the primary end points
were not reached, 500 mg oral acetazolamide, 60-90 min before intravitreal
injection, results in a statistically significant reduction in IOP at 3O min post
injection. Prophylactic treatment may be considered as an option to minimise
neuro-retinal rim damage in high-risk glaucoma patients who are most vulnerable
to IOP spikes and undergoing repeated intravitreal injections of ranibizumab.Eye 
advance online publication, 1 August 2014; doi:10.1038/eye.2014.180.

PMID: 25081290   [PubMed - as supplied by publisher]


22. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.174. [Epub ahead of print]

Short-term effects of topical cyclosporine A 0.05% (Restasis) in long-standing
prosthetic eye wearers: a pilot study.

Han JW(1), Yoon JS(2), Jang SY(1).

Author information: 
(1)Department of Ophthalmology, Soonchunhyang University Bucheon Hospital,
Soonchunhyang University College of Medicine, Bucheon,Korea.
(2)Department of Ophthalmology, Severance Hospital, Institute of Vision Research,
Yonsei University College of Medicine, Seoul, Korea.

PurposeLong-standing prosthetic eye wearing induces ocular surface inflammation. 
We investigated the short-term effects of topical cyclosporine A 0.05% (Restasis)
in patients with ocular discomfort resulting from long-standing prosthetic eye
wearing.MethodsThis was a prospective, interventional case series. Patients who
were unilateral prosthetic eye wearers over a period of 5 years were enrolled at 
a single institution from March to July 2013. The subjects were instructed to
instill topical cyclosporine A 0.05% twice per day. Measurements were made
pre-treatment and after 1 and 3 months of treatment. Outcome measures were the
ocular symptom score, the lid margin abnormality score, the Schirmer test, and
the tear meniscus amount, using Fourier-domain optical coherence
tomography.ResultsIn total, 20 consecutive patients (mean age: 60.1 years, 8
males, 12 females) were included. Ocular symptoms were improved after treatment
for 1 month in all patients (ocular symptom score pre-treatment 76.83 vs 46.75
after treatment; P<0.001). There was no statistically significant difference in
lid margin abnormality score or tear meniscus amount. The Schirmer test results
were improved after treatment for 3 months (pre- and after treatment, 6.70 vs
11.40; P<0.001).ConclusionsTopical cyclosporine A 0.05% showed a satisfactory
effect in long-standing prosthetic eye wearers. Ocular symptoms were markedly
relieved in all subjects after treatment for 1 month.Eye advance online
publication, 1 August 2014; doi:10.1038/eye.2014.174.

PMID: 25081289   [PubMed - as supplied by publisher]


23. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.179. [Epub ahead of print]

Primary black intraocular lens selection.

Yusuf IH, Fung TH, Patel CK.

Author information: 
The Oxford Eye Hospital, John Radcliffe Hospital, Oxford, UK.

PMID: 25081288   [PubMed - as supplied by publisher]


24. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.184. [Epub ahead of print]

Intraoperative modifications required during femtosecond laser-assisted cataract 
surgery for lamellar cataracts.

Grewal DS(1), Basti S(2), Grewal SP(3).

Author information: 
(1)1] Grewal Eye Institute, Chandigarh, India [2] Department of Ophthalmology,
Northwestern University Feinberg School of Medicine, Chicago, IL, USA [3]
Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
(2)Department of Ophthalmology, Northwestern University Feinberg School of Medicine,
Chicago, IL, USA.
(3)Grewal Eye Institute, Chandigarh, India.

PMID: 25081287   [PubMed - as supplied by publisher]


25. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.185. [Epub ahead of print]

Retinal sensitivity assessed by microperimetry and corresponding retinal
structure and thickness in resolved central serous chorioretinopathy.

Chung HW(1), Yun CM(2), Kim JT(3), Kim SW(2), Oh J(2), Huh K(2).

Author information: 
(1)Korea University College of Medicine, Seoul, Korea.
(2)Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
(3)Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul,
Korea.

PurposeTo investigate the relationship between retinal sensitivity (RS) assessed 
by microperimetry (MP) and retinal structural changes in patients with resolved
central serous chorioretinopathy (CSC).MethodsSpectral domain optical coherence
tomography (OCT) examination and MP tests were performed in patients with
resolved CSC. Point-to-point correlation was performed between RS and
corresponding retinal structural changes using Pearson's correlation analysis. In
addition, in a 1-mm zone in the central fovea, a correlation was calculated
between the mean RS and the mean central retinal thickness
(CRT).ResultsEighty-four eyes were analyzed. The total number of MP test points
was 1092 (84 eyes × 13 points). The mean RS and retinal point thickness (RPT) of 
all test points were 13.53±3.84 dB and 208.6±48.0 μm, respectively. The RS and
RPT were significantly decreased in the test points with loss of the ellipsoid
portion of the inner segments (EPIS) (P<0.0001). Within the 1-mm foveal center
zone, there was a significant correlation between mean RS and mean CRT (r=0.432, 
P<0.0001) and between RS and the corresponding RPT (r=0.339,
P<0.0001).ConclusionRS was dependent on the status of the EPIS in patients with
resolved CSC. The correlation between mean RS and mean CRT was compatible with
the point-to-point correlation between RS and the corresponding RPT.Eye advance
online publication, 1 August 2014; doi:10.1038/eye.2014.185.

PMID: 25081286   [PubMed - as supplied by publisher]


26. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.178. [Epub ahead of print]

Multiple sclerosis and optic nerve: an analysis of retinal nerve fiber layer
thickness and color Doppler imaging parameters.

Akçam HT(1), Capraz IY(2), Aktas Z(3), Batur Caglayan HZ(2), Ozhan Oktar S(4),
Hasanreisoglu M(3), Irkec C(2).

Author information: 
(1)Department of Ophthalmology, Cankiri State Hospital, Cankiri, Turkey.
(2)Department of Neurology, Gazi University School of Medicine, Ankara, Turkey.
(3)Department of Ophthalmology, Gazi University School of Medicine, Ankara, Turkey.
(4)Department of Radiology, Gazi University School of Medicine, Ankara, Turkey.

PurposeTo compare both retinal nerve fiber layer thickness and orbital color
Doppler ultrasonography parameters in patients with multiple sclerosis (MS)
versus healthy controls.MethodsThis is an observational case-control study. Forty
eyes from MS patients and twenty eyes from healthy volunteers were examined. Eyes
were classified into three groups as group 1, eyes from MS patients with previous
optic neuritis (n=20); group 2, eyes from MS patients without previous optic
neuritis (n=20); and group 3, eyes from healthy controls (n=20). Following
complete ophthalmologic examination and retinal nerve fiber layer thickness
measurement for each group, blood flow velocities of posterior ciliary arteries, 
central retinal artery, ophthalmic artery, and superior ophthalmic vein were
measured. Pourcelot index (resistive index), an indicator of peripheral vascular 
resistance, was also calculated. The statistical assessment was performed with
the assistance of Pearson's Chi-square test, Mann-Whitney U-test, Kruskal-Wallis 
test, and Spearman's correlation test.ResultsThe studied eyes exposed similar
values in terms of intraocular pressure and central corneal thickness, implying
no evidence in favor of glaucoma. All nerve fiber layer thickness values, except 
superior nasal quadrants, in group 1 were found to be significantly thinner than 
groups 2 and 3. Blood flow velocity and mean resistivity index parameters were
similar in all the groups.ConclusionsIn MS patients, especially with previous
optic neuritis, diminished retinal nerve fiber layer thickness was observed.
Contrary to several studies in the current literature, no evidence supporting
potential vascular origin of ocular involvement in MS was found.Eye advance
online publication, 1 August 2014; doi:10.1038/eye.2014.178.

PMID: 25081285   [PubMed - as supplied by publisher]


27. Eye (Lond). 2014 Aug 1. doi: 10.1038/eye.2014.164. [Epub ahead of print]

Macular corneal dystrophy and associated corneal thinning.

Dudakova L(1), Palos M(2), Svobodova M(2), Bydzovsky J(2), Huna L(2), Jirsova
K(1), Hardcastle AJ(3), Tuft SJ(4), Liskova P(5).

Author information: 
(1)Laboratory of the Biology and Pathology of the Eye, Institute of Inherited
Metabolic Disorders, First Faculty of Medicine, Charles University in Prague and 
General University Hospital in Prague, Prague, Czech Republic.
(2)Department of Ophthalmology, First Faculty of Medicine, Charles University in
Prague and General University Hospital in Prague, Prague, Czech Republic.
(3)Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology,
London, UK.
(4)1] Department of Ocular Biology and Therapeutics, UCL Institute of Ophthalmology,
London, UK [2] Corneal Service, Moorfields Eye Hospital NHS Foundation Trust,
London, UK.
(5)1] Laboratory of the Biology and Pathology of the Eye, Institute of Inherited
Metabolic Disorders, First Faculty of Medicine, Charles University in Prague and 
General University Hospital in Prague, Prague, Czech Republic [2] Department of
Ophthalmology, First Faculty of Medicine, Charles University in Prague and
General University Hospital in Prague, Prague, Czech Republic.

PurposeTo identify the molecular genetic cause of macular corneal dystrophy (MCD)
in four probands, and characterize phenotypic similarities between MCD and
keratoconus.MethodsWe performed ophthalmological examination, Scheimpflug imaging
(Pentacam, Oculus Inc.), histopathological examination of excised corneal
buttons, and direct sequencing of the CHST6 coding region.ResultsPentacam
measurements were taken in six eyes of three probands. All showed diffuse corneal
thinning with paracentral steepening of the anterior corneal surface that was
graded as keratoconus by the integrated software, but without associated ectasia 
of the posterior corneal surface or regional thinning. Homozygous or compound
heterozygous CHST6 mutations were identified in all cases, including two novel
mutations, c.13C>T; p.(Arg5Cys) and c.289C>T; p.(Arg97Cys).DiscussionLocalized
elevation of the anterior corneal curvature can occur in MCD in the absence of
other features of keratoconus. The identification of a further two Czech probands
with the compound allele c.[484C>G; 599T>G] supports the enrichment of this
allele in the study population.Eye advance online publication, 1 August 2014;
doi:10.1038/eye.2014.164.

PMID: 25081284   [PubMed - as supplied by publisher]


28. Eye (Lond). 2014 Jul 25. doi: 10.1038/eye.2014.155. [Epub ahead of print]

Femtosecond-assisted intrastromal corneal cross-linking for early and moderate
keratoconus.

Balidis M(1), Konidaris VE(2), Ioannidis G(3), Kanellopoulos AJ(4).

Author information: 
(1)1] Ophthalmica Eye Institute, Thessaloniki, Greece [2] AHEPA University Hospital,
Thessaloniki, Greece.
(2)AHEPA University Hospital, Thessaloniki, Greece.
(3)1] Ophthalmica Eye Institute, Thessaloniki, Greece [2] Ippocration General
Hospital, Thessaloniki, Greece.
(4)1] New York University Medical College and Manhattan Eye, Ear and Throat
Hospital, New York, NY, USA [2] Laservision.gr Institute, Athens, Greece.

PMID: 25060851   [PubMed - as supplied by publisher]


29. Eye (Lond). 2014 Jul 25. doi: 10.1038/eye.2014.165. [Epub ahead of print]

A binocular ipad treatment for amblyopic children.

Li SL(1), Jost RM(1), Morale SE(1), Stager DR(2), Dao L(3), Stager D(3), Birch
EE(4).

Author information: 
(1)Crystal Charity Ball Pediatric Vision Evaluation Center, Retina Foundation of the
Southwest, Dallas, TX, USA.
(2)Pediatric Ophthalmology and Center for Adult Strabismus, Dallas, TX, USA.
(3)Pediatric Ophthalmology and Adult Strabismus, Plano, TX, USA.
(4)1] Crystal Charity Ball Pediatric Vision Evaluation Center, Retina Foundation of 
the Southwest, Dallas, TX, USA [2] Department of Ophthalmology, University of
Texas Southwestern Medical Center, Dallas, TX, USA.

PurposeMonocular amblyopia treatment (patching or penalization) does not always
result in 6/6 vision and amblyopia often recurs. As amblyopia arises from
abnormal binocular visual experience, we evaluated the effectiveness of a novel
home-based binocular amblyopia treatment.MethodsChildren (4-12 y) wore anaglyphic
glasses to play binocular games on an iPad platform for 4 h/w for 4 weeks. The
first 25 children were assigned to sham games and then 50 children to binocular
games. Children in the binocular group had the option of participating for an
additional 4 weeks. Compliance was monitored with calendars and tracking fellow
eye contrast settings. About half of the children in each group were also treated
with patching at a different time of day. Best-corrected visual acuity,
suppression, and stereoacuity were measured at baseline, at the 4- and 8-week
outcome visits, and 3 months after cessation of treatment.ResultsMean (±SE)
visual acuity improved in the binocular group from 0.47±0.03 logMAR at baseline
to 0.39±0.03 logMAR at 4 weeks (P<0.001); there was no significant change for the
sham group. The effect of binocular games on visual acuity did not differ for
children who were patched vs those who were not. The median stereoacuity remained
unchanged in both groups. An additional 4 weeks of treatment did not yield
additional visual acuity improvement. Visual acuity improvements were maintained 
for 3 months after the cessation of treatment.ConclusionsBinocular iPad treatment
rapidly improved visual acuity, and visual acuity was stable for at least 3
months following the cessation of treatment.Eye advance online publication, 25
July 2014; doi:10.1038/eye.2014.165.

PMID: 25060850   [PubMed - as supplied by publisher]


30. Eye (Lond). 2014 Jul 25. doi: 10.1038/eye.2014.170. [Epub ahead of print]

Sterile postoperative endophthalmitis following HOYA IOL insertion.

Kumaran N(1), Larkin G(2), Hollick EJ(2).

Author information: 
(1)Department of Ophthalmology, William Harvey Hospital, Ashford, UK.
(2)Department of Ophthalmology, King's College Hospital, London, UK.

PMID: 25060849   [PubMed - as supplied by publisher]