1: Eye (Lond). 2010 Mar 5; [Epub ahead of print] 

Retinal vasculitis as an early sign of bacterial post-operative endophthalmitis.

Subbiah S, McAvoy CE, Best JL.

Royal Victoria Hospital, Belfast, County Antrim, UK.

PMID: 20203699  [PubMed - as supplied by publisher]

2: Eye (Lond). 2010 Feb 26; [Epub ahead of print] 

The Peterborough scheme for community specialist optometrists in glaucoma: a
feasibility study.

Syam P, Rughani K, Vardy SJ, Rimmer T, Fitt A, Husain T, McInerney L, Broome D,
Driver R, Wormald R, Ramirez-Florez S.

Eye Department, Peterborough & Stamford NHS Foundation Trust, Peterborough, UK.

PurposeThis study assessed the role of specialist optometrists who were working
in the community and sharing the care for glaucoma patients with, and under
close supervision of, a consultant ophthalmologist working in the Hospital Eye
Services (HES) to ensure high-quality standards, safety, and care.MethodsFrom
February 2005 onwards, the majority of all new glaucoma referrals to our eye
department were diverted to our specialist optometrists in glaucoma (SOGs) in
their own community practices. Selected patients in the HES setting who were
already diagnosed with stable glaucoma were also transferred to the SOGs. The
completed clinical finding details of the SOGs, including fundus photographs and
Humphrey visual field tests, were scrutinised by the project lead.ResultsThis
study included 1184 new patients seen by specialist optometrists between
February 2005 and March 2007. A total of 32% of patients were referred on to the
hospital, leaving the remaining 68% patients to be seen for at least their next
consultation in the community by the SOGs. The following levels of disagreement
were observed between SOGs and the project lead: on cup:disc ratio (11%), visual
field interpretation (7%), diagnosis (12%), treatment plan (10%), and outcome
(follow-up interval and location) (17%).ConclusionThis study indicates that
there is potential for a significant increase in the role of primary care
optometry in glaucoma management. The study also confirms a need for a
significant element of supervision and advice from a glaucoma specialist. The
important issue of cost effectiveness is yet to be confirmed.Eye advance online
publication, 26 February 2010; doi:10.1038/eye.2009.327.

PMID: 20186167  [PubMed - as supplied by publisher]

3: Eye (Lond). 2010 Feb 26; [Epub ahead of print] 

Juvenile xanthogranuloma: an unusual eyelid presentation.

Lim LT, McLaughlin S, Lavy T, Penman D, Dutton GN.

Eye Department, Royal Hospital for Sick Children, Glasgow, UK.

PMID: 20186166  [PubMed - as supplied by publisher]

4: Eye (Lond). 2010 Feb 26; [Epub ahead of print] 

Tattoo-associated uveitis.

Saliba N, Owen ME, Beare N.

St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.

PMID: 20186165  [PubMed - as supplied by publisher]

5: Eye (Lond). 2010 Feb 19; [Epub ahead of print] 

Re: The report 'irrigation of the capsular bag using a sealed-capsule irrigation
device and 5-fluorouracil' by Milverton.

Spalton DJ.

Department of Ophthalmology, St Thomas' Hospital, Ground Floor South Wing,
London, UK.

PMID: 20168349  [PubMed - as supplied by publisher]

6: Eye (Lond). 2010 Feb 19; [Epub ahead of print] 

Reply to Mr Spalton.

Milverton EJ.

Intraocular Implant Unit, Sydney Eye Hospital, Sydney New South Wales,
Australia.

PMID: 20168348  [PubMed - as supplied by publisher]

7: Eye (Lond). 2010 Feb 19; [Epub ahead of print] 

Spontaneous dislocation of an Artisan phakic IOL causing corneal decompensation
requiring an endothelial graft.

Harsum S, Tossounis C, Tappin MJ.

St Peters Hospital, Chertsey, England, UK.

PMID: 20168347  [PubMed - as supplied by publisher]

8: Eye (Lond). 2010 Feb 19; [Epub ahead of print] 

Changes in intraocular pressure and anterior segment morphometry after
uneventful phacoemulsification cataract surgery.

Dooley I, Charalampidou S, Malik A, Loughman J, Molloy L, Beatty S.

[1] Department of Ophthalmology, Waterford Regional Hospital, Waterford, Ireland
[2] Institute of Eye Surgery, Whitfield Clinic, Butlerstown North, Waterford,
Ireland.

PurposeTo study changes in anterior segment morphometry after uneventful
phacoemulsification cataract surgery, and to investigate whether there is a
relationship between any observed changes and intraocular pressure (IOP)
reduction after the procedure.MethodsThe anterior chamber depth (ACD), anterior
chamber volume (ACV), anterior chamber angle (ACA), central corneal thickness
(CCT), and IOP were measured in 101 non-glaucomatous eyes before and after
uneventful phacoemulsification cataract surgery.ResultsAfter cataract surgery,
the mean ACD, ACV, and ACA values increased by 1.08 mm, 54.4 mm(3), and 13.1
degrees , respectively, and the mean IOP (corrected for CCT) decreased by 3.2 mm
Hg. The predictive value of a previously described index (preoperative
ACD/preoperative IOP (corrected for CCT) or CPD ratio) for IOP (corrected for
CCT) reduction after cataract surgery was confirmed, reflected in an r(2) value
of 23.3% between these two parameters (P<0.001). Other indices predictive of IOP
reduction after cataract surgery were also identified, including preoperative
IOP/preoperative ACV and preoperative IOP/preoperative ACA, reflected in r(2)
values of 13.7 and 13.7%, respectively (P<0.001 and P<0.001,
respectively).ConclusionsOur study confirms the predictive value of the CPD
ratio for IOP reduction after cataract surgery, and may contribute to the
decision-making process in patients with glaucoma or ocular hypertension.
Furthermore, two novel indices of preoperative parameters that are predictive
for IOP reduction after cataract surgery were identified, and enhance our
understanding of the mechanisms underlying IOP changes after this procedure.Eye
advance online publication, 19 February 2010; doi:10.1038/eye.2009.339.

PMID: 20168346  [PubMed - as supplied by publisher]

9: Eye (Lond). 2010 Feb 12; [Epub ahead of print] 

Ranibizumab for retinal angiomatous proliferation in age-related macular
degeneration.

Atmani K, Voigt M, Le Tien V, Querques G, Coscas G, Soubrane G, Souied EH.

Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil,
University of Paris XII, Creteil, France.

PurposeTo assess the 1-year functional outcome and to evaluate the morphological
changes after intravitreal injections of ranibizumab in eyes affected with
retinal angiomatous proliferation (RAP) due to age-related macular degeneration
(AMD).MethodsA prospective, non-randomized, interventional study was conducted
on 26 consecutive patients with newly diagnosed RAP. All eyes were treatment
naive and were randomized to receive intravitreal injections of ranibizumab for
a 12-month period. After the first three monthly injections, re-treatment was
performed in case of best-corrected visual acuity (BCVA) loss of at least five
letters associated with fluid within the macula, central macular thickness (CMT)
increase of at least 100 mum, and/or persistence of fluid within the macula as
evaluated by optical coherence tomography, new onset macular haemorrhages,
persistence of leakage from the lesions on fluorescein angiography.ResultsAll
patients completed the 12-month follow-up: 25 of the 29 treated eyes (86.2%)
were stabilized, with a loss of less than 15 letters. Nineteen eyes (65.5%)
maintained or improved their BCVA, and three eyes (10.3%) gained three lines or
more. Overall, mean BCVA remained stable at the 12-month follow-up (-0.07
letters; P>0.05). Mean CMT significantly decreased from 386+/-147 to 216+/-74
mum at the 12-month follow-up. No significant adverse events were observed
during the study. The mean number of injections was 5.8+/-1.7 during the
follow-up period.ConclusionThe 1-year follow-up outcomes in our series suggest
that ranibizumab is an effective treatment for RAP in AMD, allowing
stabilization of BCVA and reduction of CMT.Eye advance online publication, 12
February 2010; doi:10.1038/eye.2010.9.

PMID: 20150927  [PubMed - as supplied by publisher]

10: Eye (Lond). 2010 Feb 12; [Epub ahead of print] 

Glued posterior chamber IOL in eyes with deficient capsular support: a
retrospective analysis of 1-year post-operative outcomes.

Kumar DA, Agarwal A, Prakash G, Jacob S, Saravanan Y, Agarwal A.

Dr Agarwal's Eye Hospital and Eye Research Centre, Chennai, India.

PurposeTo evaluate the post-operative outcome of fibrin glue-assisted posterior
chamber intraocular lens (IOL) implantation in eyes with deficient capsular
support after 1 year.MethodsEyes operated with fibrin glue-assisted posterior
chamber IOL implantation from December 2007 to May 2008 were included. The
post-operative best spectacle-corrected visual acuity (BCVA), uncorrected visual
acuity (UCVA), intraocular pressure (IOP), central macular thickness, and
specular count were evaluated. IOL position and centration at 1 year was
determined. The 1-year post-operative complications were analysed.ResultsA total
of 53 eyes of 53 patients were analysed. There was significant improvement in
UCVA (P=0.000) and BCVA (P=0.000). There was no significant change (P=0.447) in
IOP from the pre-operative value. The early post-operative complication was
decentration (5.6%). The late complication was pigment dispersion (3.7%) and
healed macular oedema (7.5%). No vision threatening complications such as
retinal break, retinal detachment, or endophthalmitis were seen. The percentage
(%) loss of endothelial cells was 5.23+/-3.4% at 1-year follow-up. No
pseudophakodonesis was seen in the follow-up visits.ConclusionResults obtained
at 1 year after fibrin glue-assisted posterior chamber IOL implantation showed a
good visual outcome with minimal complications in eyes with deficient capsular
support.Eye advance online publication, 12 February 2010;
doi:10.1038/eye.2010.10.

PMID: 20150926  [PubMed - as supplied by publisher]

11: Eye (Lond). 2010 Feb 12; [Epub ahead of print] 

Tear proteomics in evaporative dry eye disease.

Versura P, Nanni P, Bavelloni A, Blalock WL, Piazzi M, Roda A, Campos EC.

Ophthalmology Unit, University of Bologna, Bologna, Italy.

Purpose:To analyze tear protein variations in patients suffering from dry eye
symptoms in the presence of tear film instability but without epithelial
defects.Methods:Five microlitres of non-stimulated tears from 60 patients,
suffering from evaporative dry eye (EDE) with a break-up time (BUT) <10 s, and
from 30 healthy subjects as control (no symptoms, BUT >10 s) were collected.
Tear proteins were separated by mono and bi-dimensional SDS-PAGE electrophoresis
and characterized by immunoblotting and enzymatic digestion. Digested peptides
were analyzed by liquid chromatography coupled to electrospray ionization
quadrupole-time of flight mass spectrometry followed by comparative data
analysis into Swiss-Prot human protein database using Mascot. Statistical
analysis were performed by applying a t-test for independent data and a
Mann-Whitney test for unpaired data (P<0.05).Results:In EDE patients vscontrols,
a significant decrease in levels of lactoferrin (data in %+/-SD): 20.15+/-2.64
vs24.56+/-3.46 (P=0.001), lipocalin-1: 14.98+/-2.70 vs17.73+/-2.96 (P=0.0001),
and lipophilin A-C: 2.89+/-1.06 vs3.63+/-1.37 (P=0.006) was revealed, while a
significant increase was observed for serum albumin: 9.45+/-1.87 vs3.46+/-1.87
(P=0.0001). No changes for lysozyme and zinc alpha-2 glycoprotein (P=0.07 and
0.7, respectively) were shown. Proteomic analysis showed a downregulation of
lipophilin A and C and lipocalin-1 in patients, which is suggested to be
associated with post-translational modifications.Conclusions:Data show that tear
protein changes anticipate the onset of more extensive clinical signs in early
stage dry eye disease.Eye advance online publication, 12 February 2010;
doi:10.1038/eye.2010.7.

PMID: 20150925  [PubMed - as supplied by publisher]

12: Eye (Lond). 2010 Feb 12; [Epub ahead of print] 

The natural history of the Charles Bonnet Syndrome. Do the hallucinations go
away?

Jackson ML, Bassett KL.

Massachusetts Eye and Ear Infirmary, Harvard Department of Ophthalmology,
Boston, MA, USA.

PMID: 20150924  [PubMed - as supplied by publisher]

13: Eye (Lond). 2010 Feb 12; [Epub ahead of print] 

Comparison of three methods of intraocular pressure measurement and their
relation to central corneal thickness.

Carbonaro F, Andrew T, Mackey DA, Spector TD, Hammond CJ.

Twin Research and Genetic Epidemiology Unit, King's College London School of
Medicine, London, UK.

PurposeThe purpose of this study was to compare the reliability of the 'gold
standard' Goldmann applanation tonometer (GAT), with that of the ocular response
analyser (ORA), and the dynamic contour tonometer (DCT).Patients and methodsA
total of 694 subjects were recruited to participate from the TwinsUK (UK Adult
Twin Registry) at St Thomas' Hospital, London. Intraocular pressure (IOP) was
measured using GAT, ORA, and the DCT. The agreement between the three methods
was assessed using the Bland-Altman method. Repeatability coefficients and
coefficient of variation between first and second readings of the same eye were
used to assess reliability.ResultsMean age was 57.5 years (SD, 13.1; range,
16.1-88.5). The mean IOPs, calculated using the mean of two readings from the
right eye were as follows: Goldmann (GAT), 14.1+/-2.8 mm Hg; IOPg (ORA),
15.9+/-3.2 mm Hg; IOPcc (ORA), 16.6+/-3.2 mm Hg; and DCT, 16.9+/-2.7 mm Hg. The
95% limits of agreement were for ORA (IOPcc): GAT, -2.07 to 7.18 mm Hg; for DCT:
GAT, -0.49 to 6.21 mm Hg; and for DCT: ORA (IOPcc), -3.01 to 4.85 mm Hg.
Coefficients of variation for the three tonometers were GAT, 8.3%; ORA, 8.2%;
DCT, 6.3%. The repeatability coefficients were 3.4 mm Hg for GAT, 3.57 mm Hg for
ORA and 3.09 mm Hg for DCT. GAT and ORA (IOPg) readings showed a positive
correlation with central corneal thickness (P<0.005).ConclusionsThis study found
similar reliability in all three tonometers. Bland-Altman plots showed the three
instruments to have 95% limits of agreement outside the generally accepted
limits, which means they are not interchangeable. GAT measurements were found to
be significantly lower than the two newer instruments.Eye advance online
publication, 12 February 2010; doi:10.1038/eye.2010.11.

PMID: 20150923  [PubMed - as supplied by publisher]

14: Eye (Lond). 2010 Feb 12; [Epub ahead of print] 

Circulating markers of arterial thrombosis and late-stage age-related macular
degeneration: a case-control study.

Rudnicka AR, Maccallum PK, Whitelocke R, Meade TW.

Division of Community Health Sciences, St George's, University of London,
Cranmer Terrace, London, UK.

PurposeThe aim of this study was to examine the relation of late-stage
age-related macular degeneration (AMD) with markers of systemic
atherothrombosis.MethodsA hospital-based case-control study of AMD was
undertaken in London, UK. Cases of AMD (n=81) and controls (n=77) were group
matched for age and sex. Standard protocols were used for colour fundus
photography and to classify AMD; physical examination included height, weight,
history of or treatment for vascular-related diseases and smoking status. Blood
samples were taken for measurement of fibrinogen, factor VIIc (FVIIc), factor
VIIIc, prothrombin fragment F1.2 (F1.2), tissue plasminogen activator, and von
Willebrand factor. Odds ratios from logistic regression analyses of each
atherothrombotic marker with AMD were adjusted for age, sex, and established
cardiovascular disease risk factors, including smoking, blood pressure, body
mass index, and total cholesterol.ResultsAfter adjustment FVIIc and possibly
F1.2 were inversely associated with the risk of AMD; per 1 standard deviation
increase in these markers the odds ratio were, respectively, 0.62 (95%
confidence interval 0.40, 0.95) and 0.71 (0.46, 1.09). None of the other
atherothrombotic risk factors appeared to be related to AMD status. There was
weak evidence that aspirin is associated with a lower risk of
AMD.ConclusionsThis study does not provide strong evidence of associations
between AMD and systematic markers of arterial thrombosis, but the potential
effects of FVIIc, and F1.2 are worthy of further investigation.Eye advance
online publication, 12 February 2010; doi:10.1038/eye.2010.8.

PMID: 20150922  [PubMed - as supplied by publisher]

15: Eye (Lond). 2010 Feb 12; [Epub ahead of print] 

Use of heavy Trypan blue in macular hole surgery.

Lesnik Oberstein SY, de Smet MD.

Department of Ophthalmology, Academic Medical Center, University of Amsterdam,
Amsterdam, The Netherlands.

Purpose:Intraocular dyes facilitate the identification of the inner limiting
membrane (ILM) during surgery. Appropriate dyes should be safe, provide adequate
staining, and be easy to use. Heavy Trypan blue eliminates the need for an
air-fluid exchange (AFX) and appears to have little retinal toxicity. This study
refers to a prospective, consecutive trial with heavy Trypan blue in macular
hole surgery.Patients and methods:A consecutive group of 20 patients with full
thickness macular holes was recruited in a single institution study. Patients
were operated using conventional methods. Heavy Trypan blue was prepared by
mixing isovolumetrically glucose 10% with MembraneBlue (DORC, Zuidland, The
Netherlands). Patients were assessed for ease of surgery and post-operatively at
3 and 6 months (vision and ocular coherence tomography) for hole closure and
vision.Results:Twenty eyes were included in the study. Reapplication of dye was
used in 75% of the cases, leading to improved contrast further facilitating the
ILM peel. In no case was an AFX necessary to obtain sufficient staining. Macular
hole closure was achieved in 19 of 20 patients with one surgery. No retinal
detachment or other complication was observed in the follow-up
period.Conclusion:Heavy Trypan blue can be delivered efficiently to the retinal
surface without the need for an AFX. Staining was sufficient to help visualise
and peel the ILM. Repeat applications were easily performed. The macular hole
closure rate was similar to that of other series with a comparable visual
improvement.Eye advance online publication, 12 February 2010;
doi:10.1038/eye.2010.3.

PMID: 20150921  [PubMed - as supplied by publisher]

16: Eye (Lond). 2010 Feb 5; [Epub ahead of print] 

Surgical management of the late complications of proliferative diabetic
retinopathy.

Newman DK.

Department of Ophthalmology, Addenbrooke's Hospital, Cambridge, UK.

The late complications of proliferative diabetic retinopathy (PDR) comprise
vitreous haemorrhage, tractional retinal detachment, combined
tractional-rhegmatogenous retinal detachment, and severe fibrovascular
proliferation (including macular distortion or dragging, tractional macular
oedema, and media opacity due to fibrovascular tissue). This article will review
the indications, techniques, and outcomes of vitrectomy surgery to treat these
conditions. A careful assessment of the surgical anatomy, with particular
attention to the configuration of vitreoretinal attachments, is important when
determining the precise surgical procedure required. The surgical outcome after
diabetic vitrectomy has steadily improved with advances in vitreoretinal
surgical instrumentation and technique. Significant post-operative complications
may, however, occur including cataract formation, recurrent vitreous cavity
haemorrhage (early or delayed), rhegmatogenous retinal detachment, and
neovascular glaucoma. Most patients will regain or retain useful vision after
diabetic vitrectomy, although the visual outcome does remain unpredictable. The
development of adjunctive pharmacotherapy should enable further improvements in
visual outcome in the future.Eye advance online publication, 5 February 2010;
doi:10.1038/eye.2009.325.

PMID: 20139916  [PubMed - as supplied by publisher]

17: Eye (Lond). 2010 Feb 5; [Epub ahead of print] 

Is there an effect of perioperative blood pressure on intraoperative
complications during phacoemulsification surgery under local anaesthesia?

Agarwal PK, Mathew M, Virdi M.

Department of Ophthalmology, Hairmyres Hospitals, Lanarkshire Acute Hospitals
NHS Trust, East Kilbride, Scotland, UK.

PurposeThe practice of deferring phacoemulsification procedure on recording
raised blood pressure (BP) in the immediate perioperative period is based on the
perception of increased intraoperative risk. The significance of perioperative
BP recordings on the surgical complications during phacoemulsification procedure
was evaluated. Setting: Hairmyres Hospitals, Lanarkshire Acute Hospitals NHS
Trust.Patients and methodsPatients were classified as hypertensive on the basis
of the British Hypertension Society Guidelines. BP recordings during
preoperative assessment, admission, and 1-hour postoperatively were recorded in
734 hypertensives and 740 normotensives undergoing phacoemulsification
procedure. In addition, BP recordings in the holding area before giving local
anaesthesia were noted in the 734 hypertensives. Patient's peri- and
intraoperative complications during the procedure were noted.ResultsThe mean age
was 72+/-10.5 years and 74+/-11.6 years among the hypertensives and
normotensives. There was a significant increase in the number of hypertensives
who developed isolated systolic hypertension in the holding area (95% confidence
interval=2.82, P<0.001) where the mean BP was 171.38/78.31 mm Hg
(+/-30.55/16.29). A total of 21 hypertensives and 18 normotensives developed
intraoperative complications during the phacoemulsification procedure. There was
no significant difference (P=0.41) in the intraoperative complications between
the hypertensives and normotensives.ConclusionPerioperative increase in BP noted
in the holding area among hypertensives did not increase the risk of surgical
complications during phacoemulsification procedure when compared with
normotensives. We recommend that BP should not be routinely measured in the
holding area before phacoemulsification surgery under local anaesthesia.Eye
advance online publication, 5 February 2010; doi:10.1038/eye.2010.4.

PMID: 20139915  [PubMed - as supplied by publisher]

18: Eye (Lond). 2010 Feb 5; [Epub ahead of print] 

Targeted mydriasis strategies for diabetic retinopathy screening clinics.

Dervan EW, O'Brien PD, Hobbs H, Acheson R, Flitcroft DI.

Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin,
Ireland.

PurposeTo examine factors necessitating pupil dilation to achieve gradable
diabetic screening photographs using a digital non-mydriatic camera and to
establish techniques to predict the need for dilation and to validate
them.MethodsProspective clinic-based cross-sectional study with follow-up
validation study. The participants' involved consecutive patients attending the
diabetic retinopathy screening clinic at a University Hospital. Best corrected
visual acuity, age, sex, pupil size, mean spherical equivalent, cataract grade
and the requirement for dilation to achieve gradable photographs in 90 patients
were recorded. Data analysis using principal component analysis and multivariate
analysis of variance derived a set of equations to predict the requirement for
dilation. The predictive powers of these equations were validated in an
independent group of 51 patients.ResultsSmaller pupil size, denser nuclear
colour, older age, poorer best-corrected visual acuity, cortical lens opacity
and posterior subcapsular lens opacity were associated with the need for
dilation (P<0.001 in all). Single variables used in isolation had a poorer
predictive value than combining variables. Dilating patients with either a pupil
size >3.75 mm or age >59 years correctly allocates 83 and 78% of patients,
respectively to dilation or not. Combining pupil size with age produces a
decision table that improves the predictive value to 84%. In the validation
study this table had a predictive value of 80%.ConclusionWe have produced and
validated criteria based on a range of clinical variables for application in a
clinical setting that allows for the development of targeted mydriasis.Eye
advance online publication, 5 February 2010; doi:10.1038/eye.2009.338.

PMID: 20139914  [PubMed - as supplied by publisher]

19: Eye (Lond). 2010 Feb 5; [Epub ahead of print] 

A preliminary trial to determine whether prevention of dark adaptation affects
the course of early diabetic retinopathy.

Arden GB, Gunduz MK, Kurtenbach A, Volker M, Zrenner E, Gunduz SB, Kamis U,
Ozturk BT, Okudan S.

Department of Optometry and Visual Science, School of Community and Health
Sciences, City University, London, UK.

This study was designed to determine whether a new form of treatment of diabetic
retinopathy (DR) was acceptable to patients and whether reduction in the maximal
activity of rods in diabetes could affect the progress of DR.MethodsIn 12
patients, trans-lid retinal illumination of one eye was employed during sleep to
prevent the depolarisation of rods and thus reduce their metabolic
activity.TechniquesA headband was used to place a source of chemical light over
one eye, with its fellow as a control.MeasurementsColour contrast thresholds
were measured before and after a period of treatment in treated eyes, and the
changes were compared to those in untreated fellow eyes, and areas of 'dark
retinal anomalies' (microaneurysms, dot haemorrhages) were measured at the same
time points.ResultsPatients found this intervention to be acceptable, and no
adverse effects were noted. In the majority of cases, and for each outcome
measure, the treated eyes improved relative to their fellows. The intervention
significantly reduced the tritan thresholds in treated eyes relative to their
fellows (P=0.03), and the area of dark retinal anomalies decreased in treated
eyes and increased in untreated eyes, with a similar probability.ConclusionsThe
study showed that this intervention is safe. Although the study was not powered
to study efficiacy, the results are promising and consistent with other reports
that indicate the retina in DR is suffering from hypoxia; however, further
trials should be undertaken.Eye advance online publication, 5 February 2010;
doi:10.1038/eye.2009.328.

PMID: 20139913  [PubMed - as supplied by publisher]

20: Eye (Lond). 2010 Feb 5; [Epub ahead of print] 

Surgical outcome of single-staged three horizontal muscles squint surgery for
extra-large angle exotropia.

Lau FH, Fan DS, Yip WW, Yu CB, Lam DS.

Hong Kong Eye Hospital, Kowloon, Hong Kong, People's Republic of China.

PurposeTo report the surgical outcomes of 24 patients undergoing single-staged
three horizontal muscles squint surgery for extra-large angle exotropia.Patients
and methodsProspective case series of 24 consecutive patients with primary
exotropia >60 prism diopters (PD) at distant and underwent single-staged three
horizontal muscles squint surgery from 2003 to 2006. Surgery consisted of
bilateral lateral rectus recession of 9.0 mm for 50 PD exotropic correction. For
every 5 PD remaining angle exceeding 50 PD, we additionally performed 1.0 mm of
unilateral medial rectus resection. The mean follow-up period was 15.8 months
(range 6.0-38.0 months; SD 9.5 months).ResultsThe mean age at surgery was 31.2
years old (range 7-78 years old, SD 18.2 years old). The mean distant
preoperative deviation was 71.3 PD (range 60-85 PD, SD 7.7 PD). No limitation of
eye movement or diplopia was found. The success rate was higher in the
intermittent group (88.2%) than the constant group (42.9%) (P=0.02) and in cases
with preoperative deviation of <80 PD (84.2%) compared with those with deviation
>/=80 PD (40.0%) (P=0.042).ConclusionMeasurement of preoperative deviation and
the surgery for extra-large angle exotropia made management of this condition
difficult. Single-staged three horizontal muscles squint surgery can be one of
the options. Further researches on management of exotropia of >80 PD are
warranted.Eye advance online publication, 5 February 2010;
doi:10.1038/eye.2010.5.

PMID: 20139912  [PubMed - as supplied by publisher]

21: Eye (Lond). 2010 Feb 5; [Epub ahead of print] 

Eyelid necrosis after local anaesthesia for lacrimal sac surgery.

Mili-Boussen I, Errais K, Chebil A, Daghfous R, Belkahia C, Quertani A.

Department of Ophthalmology, Charles Nicolle Hospital, University of Medicine of
Tunis, Tunis, Tunisia.

PMID: 20139911  [PubMed - as supplied by publisher]