Journal Contents

Am Jour Ophthalmol
Br J Ophthalmol
Can J Ophthalmol
J Cat Ref Surg
Curr Eye Res
Eur J Ophthalmol
J Glaucoma
JAMA Ophthalmol
Graefes Ophthalmol
Indian J Ophthalmol
Int Ophthalmol Clin
Invest Ophth Vis Sci
Jpn J Ophthalmol
Korean J Ophthal
J Neuroophthalmol
Ophthalmic Epidemiol
Ophthalmic Genet
Ophthal Plast Rec Surg
Ophthalmic Res
Surv Ophthalmol
Ophthalmology Review Journal
Eye[JOUR] Established 1995
1. Eye (Lond). 2015 Feb 27. doi: 10.1038/eye.2015.19. [Epub ahead of print]

Response to 'Opaque intraocular lens implantation'

Yusuf IH(1), Fung TH(1), Patel CK(1).

Author information: 
(1)The Oxford Eye Hospital, West Wing, John Radcliffe Hospital, Oxford, UK.

PMID: 25721521   [PubMed - as supplied by publisher]

2. Eye (Lond). 2015 Feb 27. doi: 10.1038/eye.2015.10. [Epub ahead of print]

Blood flow velocity measured using the Retinal Function Imager predicts
successful ranibizumab treatment in neovascular age-related macular degeneration:
early prospective cohort study.

Böhni SC(1), Howell JP(1), Bittner M(1), Faes L(1), Bachmann LM(2), Thiel MA(1), 
Schmid MK(1).

Author information: 
(1)Eye Clinic, Cantonal Hospital of Lucerne, Lucerne, Switzerland. (2)Medignition
Inc. Research Consultants, Zurich, Switzerland.

PurposeAnti-VEGF treatment has a potent vasoconstrictive effect. Early changes of
retinal blood flow velocity (RBFV) measured using the Retinal Function Imager
(RFI) combined with indicators of vascular status may help in predicting the
visual outcome 1 month post injection in patients with neovascular age-related
macular degeneration (nvAMD) under ranibizumab treatment. To develop a simple
prediction model based on the change in RBFV 3 days post injection and indicators
of a patient's vascular status to assess the probability of a successful visual
outcome 1 month post injection.MethodsRBFV measured using RFI were prospectively 
collected pre-injection and 3 days post injection in 18 eyes of 15 patients.
Indicators of vascular status (history of hypertension, diabetes mellitus without
retinal affection, and smoking) were assessed by medical history. By univariate
analyses, parameters associated with visual outcome were weighted (-1 to 6
points). A multivariate logistic regression model with the categorized visual
outcome parameter (≥0 letters gained after 1 month) as the dependent variate and 
the sum score as the independent variate (continuous scale) was used to estimate 
the score value-specific probabilities of letters gained ≥0 1 month post
injection.ResultsThe indicators of vascular status negatively influenced the
likelihood of a letter gain ≥0 whereas an increase in the arterial RBFV strongly 
increased it. The area under the receiver operating characteristics curve for
these parameters investigated was 0.71 (95% CI: 0.43-1.00).ConclusionChanges in
the arterial RBFV following 3 days after ranibizumab injection combined with
three indicators of the vascular status identified nvAMD patients with favorable 
visual outcome accurately.Eye advance online publication, 27 February 2015;

PMID: 25721520   [PubMed - as supplied by publisher]

3. Eye (Lond). 2015 Feb 27. doi: 10.1038/eye.2015.15. [Epub ahead of print]

Opaque intraocular lens implantation.

Gong JW(1), O'Colmain U(1), MacEwen CJ(1).

Author information: 
(1)NHS Tayside Ophthalmology Department, Ninewells Hospital and Medical School,
Dundee, UK.

PMID: 25721519   [PubMed - as supplied by publisher]

4. Eye (Lond). 2015 Feb 27. doi: 10.1038/eye.2015.17. [Epub ahead of print]

Comparison of visual field progression between temporally tilted disc and
nontilted disc, in patients with normal tension glaucoma.

Choy YJ(1), Kwun Y(2), Han JC(2), Kee C(2).

Author information: 
(1)Department of Ophthalmology, Eul-ji University Hospital, Daejeon, Korea.
(2)Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University
School of Medicine, Seoul, Korea.

PurposeTo investigate the long-term visual field (VF) progression of temporally
tilted disc and nontilted disc in normal tension glaucoma
(NTG).MethodsRetrospective, observational case series. Forty-seven patients with 
temporally tilted disc (47 eyes), 44 patients with nontilted disc in NTG (44
eyes) patients, who were examined by at least 5 VF tests, and were followed-up
over a 5-year period, at the Department of Ophthalmology of the Samsung Medical
Center, from May 1998 to 2013. VF progression was defined by modified
Anderson-Hodapp criteria, and Glaucoma Progression Analysis (GPA). Multivariate
analysis was used to identify the risk factors for VF progression in the
temporally tilted disc.ResultsAccording to the Anderson-Hodapp criteria,
progression rates of the temporally tilted disc and nontilted disc at 60 months
were 19% and 72%, respectively (P<0.0001). According to GPA, they were 25% and
53%, respectively (P<0.0001). Twenty of 47 patients in the temporally tilted disc
did not show progression. Among them, the more tilted disc showed the more VF
defects. The hazard ratio of retinal nerve fiber layer (RNFL) defect type was
3.08 (95% CI, 1.17-8.14; P=0.02). The simultaneous superior and inferior RNFL
defect type was the most common in progressors in the temporally tilted disc
(P=0.04).ConclusionThrough long-term follow-up, the cumulative survival rate of
temporally tilted disc was higher than that of nontilted disc. Caution is
required in the treatment of the temporally tilted disc. New treatment policy for
the temporally tilted disc may follow.Eye advance online publication, 27 February
2015; doi:10.1038/eye.2015.17.

PMID: 25721518   [PubMed - as supplied by publisher]

5. Eye (Lond). 2015 Feb 27. doi: 10.1038/eye.2015.13. [Epub ahead of print]

Mini-incision cataract surgery and toric lens implantation for the reduction of
high myopic astigmatism in patients with pellucid marginal degeneration.

Balestrazzi A(1), Baiocchi S(1), Balestrazzi A(2), Cartocci G(1), Tosi GM(1),
Martone G(1), Michieletto P(2).

Author information: 
(1)Ophthalmology Unit, Department of Medicine, Surgery and Neuroscience,
University of Siena, Siena, Italy. (2)Department of Medicine, Surgery and
Neuroscience, Ophthalmic Hospital, Rome, Italy.

PurposeTo evaluate the clinical outcomes, safety, and efficacy of cataract
surgery with the implantation of a toric intraocular lens (IOL) in eyes with
stable pellucid marginal degeneration (PMD).MethodsEleven eyes (eight patients)
diagnosed as stable PMD and cataract underwent mini-incision 2.2 mm cataract
surgery followed by the implantation of hydrophobic toric aspheric IOL (AcrySof
IQ Toric IOL, Alcon, Fort Worth, TX, USA). Perioperative variables of interest
included uncorrected (UDVA) and corrected (CDVA) distance visual acuities,
manifest refraction, and corneal topography. Paired samples t-tests were used to 
analyze preoperative and postoperative visual acuity, astigmatism, and spherical 
equivalent (SE) parameters. Follow-up was 6 months.ResultsThe mean CDVA was
0.62±0.26 logMAR preoperatively and 0.07±0.07 logMAR postoperatively. The mean
preoperative sphere and cylinder was -3.14±3.58D and -4.84±2.02D, respectively.
The mean postoperative manifest refractive sphere and cylinder was -0.30±0.51D
and -0.81±1.51D, respectively. There was a significant reduction in refractive
astigmatism after toric IOL implantation (P<0.002). The toric IOL axis rotation
was <5° in all cases at the final follow-up.ConclusionsImplantation of
hydrophobic toric IOL was a safe and effective surgical procedure to correct mild
to moderate stable PMD.Eye advance online publication, 27 February 2015;

PMID: 25721517   [PubMed - as supplied by publisher]

6. Eye (Lond). 2015 Feb 27. doi: 10.1038/eye.2015.8. [Epub ahead of print]

Methodological remarks concerning the recent meta-analysis on the effect of
intravitral bevacizumab in central serous chorioretinopathy.

Sergentanis TN(1), Chatziralli IP(2).

Author information: 
(1)Department of Epidemiology and Biostatistics, University of Athens, Athens,
Greece. (2)Second Department of Ophthalmology, Ophthalmiatrion Eye Hospital,
Athens, Greece.

PMID: 25721516   [PubMed - as supplied by publisher]

7. Eye (Lond). 2015 Feb 27. doi: 10.1038/eye.2015.5. [Epub ahead of print]

Reply to 'Lack of positive effect of intravitreal bevacizumab in central serous
chorioretinopathy: meta-analysis and review'

Lee K(1), Chung YR(1).

Author information: 
(1)Department of Ophthalmology, Ajou University School of Medicine, Suwon,
Republic of Korea.

PMID: 25721515   [PubMed - as supplied by publisher]

8. Eye (Lond). 2015 Feb 20. doi: 10.1038/eye.2014.344. [Epub ahead of print]

Macular hole in retinitis pigmentosa patients: microincision vitrectomy with
polydimethylsiloxane as possible treatment.

Vingolo EM(1), Valente S(1), Gerace E(1), Spadea L(1), Nebbioso M(2).

Author information: 
(1)Department of Ophthalmology, Polo Pontino, Policlinico Umberto I, Sapienza
University of Rome, Rome, Italy. (2)Department of Sense Organs, Ocular
Electrophysiology Center, Faculty of Medicine and Odontology, Policlinico Umberto
I, Sapienza University of Rome, Rome, Italy.

PurposeTo investigate long-term retinal changes after microincision pars plana
vitrectomy surgery (MIVS) for macular hole (MH) in retinitis pigmentosa (RP)
patients-retrospective and observational study.MethodsThree RP patients suffering
from MH were evaluated by means of best corrected visual acuity, anterior and
posterior binocular examination, spectralis high-resolution optical coherence
tomography, MP-1 microperimetry (MP-1), and full-field electroretinogram (ERG),
before MIVS and during the 36-month follow-up. Patients underwent simultaneous
MIVS and microincision cataract surgery; IOL was positioned in capsular bag.
Patients were hospitalised for 2 days after the surgery. Surgical procedure was
performed according the following schedule: surgical removal of crystalline lens,
MIVS with 23-gauge sutureless system trocars, core vitreous body removal, peeling
of the inner limiting membrane, and balanced sterile saline
solution-air-micro-structured polydimethylsiloxane (PDMS) exchange. PDMS
tamponade, after 6 months starting from MIVS, was removed.ResultsIn all patients 
visual acuity increased after vitrectomy as a consequence of complete MH closure 
and restoration of retinal architecture. None of the patients developed ocular
hypertension, or re-opening of MH during the 3-year follow-up. MP-1 bivariate
contour ellipse area was reduced in its dimensions and improved in all patients
demonstrating a better fixation.ConclusionsMIVS could be an effective treatment
in RP patients with MH if medical therapy is not applicable or not sufficient.
Finally more studies will be needed to improve knowledge about this genetic
disease.Eye advance online publication, 20 February 2015;

PMID: 25697459   [PubMed - as supplied by publisher]

9. Eye (Lond). 2015 Feb 20. doi: 10.1038/eye.2015.9. [Epub ahead of print]

The accuracy of the Edinburgh Red Eye Diagnostic Algorithm.

Timlin H(1), Butler L(1), Wright M(1).

Author information: 
(1)Princess Alexandra Eye Pavilion, Edinburgh, UK.

PurposeTo assess the diagnostic accuracy of the Edinburgh Red Eye
Algorithm.MethodsThis was a prospective study. A questionnaire was designed and
made available to clinicians referring patients to the acute ophthalmology
service within Edinburgh. The questionnaire involved them using the algorithm to 
reach a diagnosis in patients presenting with red eye(s). Patients were then
referred to the emergency eye clinic and the questionnaire faxed to the clinic or
sent with the patients. Patients were then examined by an experienced
ophthalmologist (not blinded) to reach a 'gold standard' diagnosis. The
concordance between the 'algorithm assisted' diagnosis and the 'gold standard'
was then assessed.ResultsAll patients presenting with red eye(s) were eligible
for inclusion. Forty-one questionnaires were completed, two were excluded. The
algorithm assisted diagnosis was correct 72% (28/39) of the time. It correctly
diagnosed: acute angle closure glaucoma in 100% of cases (4/4); iritis in 82%
(9/11); stromal keratitis in 63% (5/8); epithelial keratitis in 70% (7/10); and
infective conjunctivitis in 50% (3/6).DiscussionThe diagnostic accuracy of The
Edinburgh Red Eye Diagnostic Algorithm is 72, rising to 76% when only the most
serious red eye(s) causes are included. The diagnostic accuracy of
nonophthalmologists when assessing patients presenting with red eye(s) is greater
when the algorithm is used. We hope that the use of this algorithm will prevent
delayed presentations of certain serious eye conditions and reduce the morbidity 
from delayed treatment.Eye advance online publication, 20 February 2015;

PMID: 25697458   [PubMed - as supplied by publisher]

10. Eye (Lond). 2015 Feb 20. doi: 10.1038/eye.2015.1. [Epub ahead of print]

Randomised clinical trial evaluating best-corrected visual acuity and central
macular thickness after 532-nm subthreshold laser grid photocoagulation treatment
in diabetic macular oedema.

Pei-Pei W(1), Shi-Zhou H(1), Zhen T(1), Lin L(1), Ying L(1), Jiexiong O(1),
Wen-Bo Z(1), Chen-Jin J(1); Medscape.

Author information: 
(1)State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun
Yat-sen University, Guangzhou, China.

PurposeTo compare best-corrected visual acuity (BCVA) and central macular
thickness (CMT) after 532-nm subthreshold laser grid photocoagulation and
threshold laser grid photocoagulation for the treatment of diabetic macular
oedema (DME).Patients and methodsTwenty-three patients (46 eyes) with binocular
DME were enroled in this study. The two eyes of each patient were divided into a 
subthreshold photocoagulation group and a threshold photocoagulation group. The
eyes of the subthreshold group underwent 532-nm patter scan laser system (PASCAL)
50% end point subthreshold laser grid photocoagulation therapy, whereas the
threshold photocoagulation group underwent short-pulse grid photocoagulation with
a 532-nm PASCAL system. BCVA and CMT were assessed in all patients before
treatment, 7 days after treatment, and 1, 3, and 6 months after
treatment.ResultsAfter grid photocoagulation, the mean BCVA improved in both the 
subthreshold group, and the threshold group, and the two groups did not differ
statistically significantly from each other. Similarly, the macular oedema
diminished in both groups after treatment, and the two groups did not differ
statistically significantly from each other with regard to CMT.ConclusionBoth
532-nm subthreshold laser grid photocoagulation and threshold laser grid
photocoagulation can improve the visual acuity and reduce CMT in DME patients.Eye
advance online publication, 20 February 2015; doi:10.1038/eye.2015.1.

PMID: 25697457   [PubMed - as supplied by publisher]

11. Eye (Lond). 2015 Feb 20. doi: 10.1038/eye.2014.331. [Epub ahead of print]

Is the 1-day postoperative IOP check needed post uncomplicated
phacoemulsification in patients with glaucoma and ocular hypertension?

Gupta A(1), Vernon SA(1).

Author information: 
(1)Ophthalmology Department, Queen's Medical Centre, Nottingham, UK.

PurposeTo determine whether the 1-day postoperative intraocular pressure (IOP)
check following routine uncomplicated phacoemulsification is necessary in
patients with pre-existing glaucoma and ocular hypertension (OHT), if
acetazolamide prophylaxis is used. To investigate the practice of UK glaucoma
specialists in IOP rise prophylaxis and follow-up regimes.Patients and methodsThe
IOP 1-day postoperatively was analysed against the last recorded IOP before
phacoemulsification in a cohort of patients with glaucoma or OHT who underwent
uncomplicated phacoemulsification cataract surgery between December 2009 and
September 2012, where it was routine practice to give acetazolamide
postoperatively. UK and Eire Glaucoma Society members were surveyed via an online
questionnaire to analyse practice among UK glaucoma specialists.ResultsOne
hundred and seven eyes were studied: 99 with glaucoma and 8 with OHT. The mean
IOP change was -0.8 mm Hg with only two eyes measuring >30 mm Hg postoperatively 
(2%). Both these eyes received 750 mg acetazolamide. Eighteen (17%) eyes had an
IOP rise of at least 30%. In the survey of practice there were 65 respondents.
Twenty-one (32%) respondents did not use IOP prophylaxis. Only 17 (26%) of
respondents routinely reviewed their patients 1-day postoperatively.ConclusionOur
prophylactic acetazolamide regime does not completely eliminate the risk of an
IOP >30 mm Hg on day 1 post routine phacoemulsification in glaucoma/OHT patients.
Patients with pre-existing glaucoma, despite acetazolamide prophylaxis, will
require IOP management decisions on the first postoperative day after
uncomplicated phacoemulsification surgery. UK expert practice is non-uniform with
regard to IOP prophylaxis, and the 1-day review, and further discussion and
formulation of consensus appears necessary.Eye advance online publication, 20
February 2015; doi:10.1038/eye.2014.331.

PMID: 25697456   [PubMed - as supplied by publisher]

12. Eye (Lond). 2015 Feb 20. doi: 10.1038/eye.2015.11. [Epub ahead of print]

Longitudinal analysis of age-related changes in intraocular pressure in South

Baek SU(1), Kee C(2), Suh W(3).

Author information: 
(1)Department of Ophthalmology, Hallym University Sacred Heart Hospital, Hallym
University College of Medicine, Anyang, Korea. (2)Department of Ophthalmology,
Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
(3)Department of Ophthalmology, Hallym University Dongtan Sacred Heart Hospital, 
Hallym University College of Medicine, Hwaseong, Korea.

PurposeTo assess the changes in intraocular pressure (IOP) with age in South
KoreaMethodsSubjects aged 20-79 who had been receiving health examinations at a
university hospital were enrolled. They completed physical and ophthalmic
examinations. Subjects with ocular disease that could possibly affect their IOP
were excluded. The relationships between IOP and age, blood pressure, heart rate,
body mass index, blood chemistry, and electrolyte were analyzed using a linear
mixed model.ResultsOf the 33 712 subjects, 31 857 participants were enrolled. In 
a cross-sectional analysis, IOP also showed a negative correlation in all age
groups (respectively, P<0.001). In particular, patients in their 60s~80s had a
less steep decreasing slope of IOP with age than patients in their 20s~30s
(correlation coefficient -0.260 and -0.168, respectively). In longitudinal
analysis, negative trend was shown in the slope of tendency in total subjects.
When analyzing the effect of gender on the relationship between age and IOP,
females had a less steep decreasing slope of IOP with age than males by
0.05 mm Hg. With regard to systemic parameters, systolic blood pressure and heart
rate were positively correlated with IOP (P<0.001).ConclusionIOP was
significantly decreased with age, although the amount of change was small. In
women and older age groups, IOP was less decreased than that of men and young age
groups. In addition, IOP was positively associated with systolic blood pressure
and heart rate.Eye advance online publication, 20 February 2015;

PMID: 25697455   [PubMed - as supplied by publisher]

13. Eye (Lond). 2015 Feb 13. doi: 10.1038/eye.2015.6. [Epub ahead of print]

The absence of focal choroidal excavation in children and adolescents without
retinal or choroidal disorders or ocular trauma.

Park KA(1), Oh SY(1).

Author information: 
(1)Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University
School of Medicine, Seoul, Korea.

PMID: 25679416   [PubMed - as supplied by publisher]

14. Eye (Lond). 2015 Feb 13. doi: 10.1038/eye.2014.337. [Epub ahead of print]

Blood-aqueous barrier integrity in patients with Graves' ophthalmopathy (GO),
before and after rehabilitative surgery.

Kłysik A(1), Kozakiewicz M(2).

Author information: 
(1)Department of Ophthalmology, Medical University of Lodz, Lodz, Poland.
(2)Department of Maxillofacial Surgery, Medical University of Lodz, Lodz, Poland.

PurposeThe study was conducted to analyze aqueous flare and its correlations in
patients with Graves' ophthalmopathy (GO) undergoing orbital decompression,
extraocular muscle, and eyelid surgery. Prospective interventional case
series.Patients and MethodsForty-eight eyes of 27 patients (20 female and 7 male,
aged 54.4±5.7) undergoing surgical treatment for GO. Eighteen eyes of nine
patients (aged 55.3±3.6) undergoing orbital decompression. Nineteen eyes of 11
patients (aged 54.7±5.6) undergoing extraocular muscle surgery and 13 eyes of 7
patients (aged 53.9±4.9) undergoing eyelid surgery and control group (34 patients
aged 53.9±5.1). Laser flare analysis and clinical assessment were performed
before surgery and at 1 day, 7 days, and 3 months following
surgery.ResultsAqueous flare was significantly higher in patients with GO
(14.03±8.45) before intervention than in the control group (7.89±3.56) (P<0.001),
and correlated with Clinical Activity Score and intraocular pressure. In the
patients undergoing orbital decompression, flare increased from 17.77±10.63 pc/ms
to 38.32±13.56 pc/ms on the first day and 41.31±17.19 pc/ms on the seventh day
and returned to 16.01±8.58 pc/ms in 3 months. In patients undergoing extraocular 
muscle surgery flare increased from 13.05±6.50 to 23.04±11.53 pc/ms (P<0.001) on 
the first day and returned to 18.02±14.09 pc/ms on the seventh day. Eyelid
surgery did not change flare values.ConclusionsOrbital decompression disrupts
blood-aqueous barrier (BAB). The integrity of BAB returns to preoperative status 
within 3 months. Extraocular muscle surgery mildly affects BAB integrity, and the
effect subsides within 7 days. Eyelid surgery does not affect BAB.Eye advance
online publication, 13 February 2015; doi:10.1038/eye.2014.337.

PMID: 25679415   [PubMed - as supplied by publisher]

15. Eye (Lond). 2015 Feb 13. doi: 10.1038/eye.2015.7. [Epub ahead of print]

Trends in serious ocular trauma in Scotland.

Desai P(1), Morris DS(2), Minassian DC(3), MacEwen CJ(4).

Author information: 
(1)Moorfields Eye Hospital NHS Foundation Trust, London, UK. (2)Cardiff Eye Unit,
University Hospital of Wales, Cardiff, UK. (3)Institute of Ophthalmology,
University College London, London, UK. (4)University Department of Ophthalmology,
Ninewells Hospital, Dundee, Scotland.

PurposeTo report trends in serious, sight-threatening ocular trauma in
Scotland.MethodsA prospective, population-based, observational study of patients 
with ocular trauma admitted to hospital in Scotland during a 12-month period
(2008-2009), conducted through the British Ophthalmic Surveillance Unit. Data on 
circumstances of the injuries and visual outcomes were collected using protocols 
standardised to those from an earlier study (1991-1992) to allow direct
comparisons over time.ResultsIn all, 0.3% of all emergency admissions in Scotland
were for ocular trauma. Significant differences were observed between the time
periods in where an injury occurred (P=0.009): a reduction of those occurring in 
a sports/leisure facility (8.2%) and an increase in those occurring on the street
(21.4%). Assaults remained the most common cause of injury (31%). Gender
differences persisted with females more likely to have an injury from falls
(OR=8.67; 95% CI: 2.41-31.49; P=0.002), or in the home (OR=5.40; 95% CI:
1.69-17.16; P=0.009 ), and less likely to have one in the workplace (P=0.06).
Poor visual outcome was associated with injuries occurring in the home (OR=4.33, 
P=0.047), in a public place (OR=6.25, P=0.047), and those caused by a fall (OR
42.75, P<0.001); or assault (OR 7.29, P=0.019). Half of those with a poor outcome
have no perception of light.ConclusionSerious ocular trauma remains an
infrequent, sight-threatening event, associated with significant monocular visual
morbidity. The findings suggest a shift from corporate to personal responsibility
for risk awareness, health, and safety.Eye advance online publication, 13
February 2015; doi:10.1038/eye.2015.7.

PMID: 25679414   [PubMed - as supplied by publisher]

16. Eye (Lond). 2015 Feb 13. doi: 10.1038/eye.2015.3. [Epub ahead of print]

The Royal College of Ophthalmologists' National Ophthalmology Database study of
cataract surgery: report 1, visual outcomes and complications.

Day AC(1), Donachie PH(2), Sparrow JM(3), Johnston RL(2).

Author information: 
(1)The NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation 
Trust and UCL Institute of Ophthalmology, London, UK. (2)1] The Royal College of 
Ophthalmologists' National Ophthalmology Database, London, UK [2] Gloucestershire
Hospitals NHS Foundation Trust, Cheltenham, UK. (3)1] The Royal College of
Ophthalmologists' National Ophthalmology Database, London, UK [2] Department of
Ophthalmology, Bristol Eye Hospital, Bristol, UK.

AimsTo describe the outcomes of cataract surgery in the United
Kingdom.MethodsAnonymised data on 180 114 eyes from 127 685 patients undergoing
cataract surgery between August 2006 and November 2010 were collected
prospectively from 28 sites. Outcome measures included intraoperative and
postoperative complication rates, and preoperative and postoperative visual
acuities.ResultsMedian age at first eye surgery was 77.1 years, 36.9% cases had
ocular co-pathology and 41.0% patients underwent cataract surgery on both eyes.
Preoperative visual acuity was 0.30 logMAR or better in 32.0% first eyes and
47.7% second eyes. Postoperative best-measured visual acuity was 0.00 and 0.30
logMAR or better in 50.8 and 94.6% eyes without ocular co-pathology, and 32.5 and
79.9% in eyes with co-pathology. For eyes without co-pathology, postoperative
uncorrected distance visual acuity was 0.00 and 0.30 logMAR or better in 27.3 and
80.9% eyes. Posterior capsule rupture or vitreous loss or both occurred in 1.95% 
cases, and was associated with a 42 times higher risk of retinal detachment
surgery within 3 months and an eight times higher risk of
endophthalmitis.ConclusionThese results provide updated data for the benchmarking
of cataract surgery. Visual outcomes, and the rate of posterior capsule rupture
or vitreous loss or both appear stable over the past decade.Eye advance online
publication, 13 February 2015; doi:10.1038/eye.2015.3.

PMID: 25679413   [PubMed - as supplied by publisher]

17. Eye (Lond). 2015 Feb;29(2):300. doi: 10.1038/eye.2014.307.

Drusen and RPE atrophy automated quantification by optical coherence tomography
in an elderly population.

Diniz B, Rodger DC, Chavali VR, MacKay T, Lee SY, Stambolian D, Sadda SV.

PMCID: PMC4330299 [Available on 2016-02-01]
PMID: 25672510   [PubMed - in process]

18. Eye (Lond). 2015 Feb;29(2):299. doi: 10.1038/eye.2014.306.

The cerebellum in eye movement control: nystagmus, coordinate frames and

Patel VR, Zee DS.

PMCID: PMC4330298 [Available on 2016-02-01]
PMID: 25672509   [PubMed - in process]

19. Eye (Lond). 2015 Feb 6. doi: 10.1038/eye.2014.309. [Epub ahead of print]

Vertical rectus transposition in Duane's syndrome: does co-contraction worsen?

Bhambhwani V(1), Pandey PK(1), Sood S(1), Rana K(1).

Author information: 
(1)Guru Nanak Eye Centre and Maulana Azad Medical College, New Delhi, India.

PMID: 25657043   [PubMed - as supplied by publisher]

20. Eye (Lond). 2015 Feb 6. doi: 10.1038/eye.2014.310. [Epub ahead of print]

Reply: Vertical rectus transposition in Duane's syndrome: does co-contraction

Akar S(1), Gokyigit B(2), Pekel G(3), Demircan A(2), Demirok A(2).

Author information: 
(1)Department of Ophthalmology, Faculty of Medicine, Baskent University,
Istanbul, Turkey. (2)Pediatric Ophthalmology and Strabismus Department, Professor
Dr N Reşat Belger Beyoglu Education and Research Eye Hospital, Istanbul, Turkey. 
(3)Department of Ophthalmology, Faculty of Medicine, Pamukkale University,
Denizli, Turkey.

PMID: 25657042   [PubMed - as supplied by publisher]

21. Eye (Lond). 2015 Feb 6. doi: 10.1038/eye.2014.343. [Epub ahead of print]

Multiphasic changes in systemic VEGF following intravitreal injections of
ranibizumab in a child.

Shao EH(1), Sivagnanavel V(2), Dabbagh A(2), Dave R(2), Tempest-Roe S(3), Tam
FW(3), Taylor SR(1).

Author information: 
(1)1] Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, 
London, UK [2] Royal Surrey County Hospital NHS Foundation Trust, Egerton Road,
Guildford, UK. (2)Kingston Hospital NHS Foundation Trust, Galsworthy Road,
Kingston-upon-Thames, Surrey, UK. (3)Faculty of Medicine, Imperial College
London, Hammersmith Hospital Campus, London, UK.

PurposeTo investigate whether intravitreal ranibizumab injections administered to
a child alter systemic plasma levels of total and free VEGF 165.MethodsA
9-year-old child sustained a choroidal rupture from blunt trauma. He subsequently
developed a secondary choroidal neovascular membrane, which was treated with five
ranibizumab injections over a period of 8 months. Peripheral venous blood samples
were taken at each visit over a period of 12 months and plasma was extracted.
Plasma VEGF 165 levels were determined using enzyme-linked immunosorbent assay
and were assayed both pre- and post-immunodepletion to remove complexed
VEGF.ResultsPlasma VEGF 165 levels proved labile following intravitreal injection
of ranibizumab. Levels increased by 30% above baseline following the first
intravitreal ranibizumab injection, but then returned to baseline despite two
subsequent injections. There was then a rebound increase of 67% in total plasma
VEGF levels following a further injection, which remained above baseline for 12
weeks despite two further intravitreal ranibizumab injections. Baseline levels
were re-attained 26 weeks after the final injection.ConclusionsThese results
suggest intravitreal ranibizumab injections can cause significant, multiphasic
changes in systemic VEGF levels. This may be of particular clinical significance 
in children as VEGF is known to be vital in the development of major organs, in
addition to its role in the maintenance of normal organ function in adults.Eye
advance online publication, 6 February 2015; doi:10.1038/eye.2014.343.

PMID: 25657041   [PubMed - as supplied by publisher]

22. Eye (Lond). 2015 Feb 6. doi: 10.1038/eye.2014.332. [Epub ahead of print]

Enterococcus casseliflavus endophthalmitis due to metallic intraocular foreign

Low JR(1), Teoh CS(1), Chien JM(2), Huang EH(3).

Author information: 
(1)Singapore National Eye Centre, Singapore. (2)Department of Infectious
Diseases, Singapore General Hospital, Singapore. (3)Singapore International Eye
Cataract Retina Centre, Singapore.

PMID: 25657040   [PubMed - as supplied by publisher]