1: Eye (Lond). 2010 Jul 23; [Epub ahead of print] 

24-h Intraocular pressure control with evening-dosed travoprost/timolol,
compared with latanoprost/timolol, fixed combinations in exfoliative glaucoma.

Konstas AG, Mikropoulos DG, Embeslidis TA, Dimopoulos AT, Papanastasiou A,
Haidich AB, Stewart WC.

Glaucoma Unit, Department of Ophthalmology, First University, Thessaloniki,
Greece.

PurposeTo evaluate 24-h efficacy of travoprost/timolol fixed combination (TTFC)
vslatanoprost/timolol fixed combination (LTFC) in exfoliative glaucoma
(XFG).DesignA prospective, single-masked, crossover, active-controlled,
randomized 24-h comparison.MethodsAfter up to a 6-week medicine-free period, XFG
patients were randomized to either TTFC or LTFC for 3 months, dosed each
evening, and then changed to the opposite treatment for another 3 months. At the
end of the washout, and both treatment periods, a 24-h intraocular pressure
(IOP) curve was measured.ResultsIn total, 40 patients completed the study. The
TTFC group showed a lower mean absolute 24-h IOP (18.7+/-2.6 vs19.6+/-2.6 mm Hg,
P<0.001), maximum IOP (20.5+/-2.6 vs21.5+/-2.6 mm Hg, P<0.001) and 24-h IOP
range (3.4+/-1.3 vs4.1+/-1.6 mm Hg, P=0.01). At individual time points, TTFC
showed reduced IOPs compared with LTFC, after a Bonferroni correction, at 1000,
1800, and 2200 hours (P/=0.05) and for the minimum IOP (P=0.09).ConclusionsThis
study suggests that evening-dosed TTFC may provide greater 24-h IOP reduction,
primarily at the 1800 hours time point, compared with LTFC in XFG.Eye advance
online publication, 23 July 2010; doi:10.1038/eye.2010.100.

PMID: 20651749  [PubMed - as supplied by publisher]

2: Eye (Lond). 2010 Jul 23; [Epub ahead of print] 

The relationship between the cornea and the optic disc.

Kim JM, Park KH, Kim SH, Kang JH, Cho SW.

Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk
Samsung Hospital, Seoul, Korea.

ObjectiveTo evaluate the structural relationship between the cornea and the
optic disc in normal subjects.MethodsThis hospital-based observational study
included 205 eyes from 205 individuals who were diagnosed as normal at our
glaucoma clinic. The subjects underwent an eye examination, optic disc imaging
with optic disc photography, optical coherence tomography, IOL master, specular
microscopy, and ultrasound corneal pachymetry.ResultsIn univariate regression
models (Pearson's correlation coefficient), the cup-to-disc (CD) ratio showed a
negative correlation with corneal curvature (r=-0.315, P<0.001) and central
corneal thickness (r=-0.206, P=0.005), and a positive correlation with
white-to-white diameter (horizontal limbus to limbus distance, r=0.215,
P=0.003). In multiple linear regression models with CD ratio as the dependant
parameter, the CD ratio was still significantly associated with corneal
curvature (beta=-0.205, P=0.011) and white-to-white diameter (beta=0.207,
P=0.010). The central corneal thickness failed to show statistical significance,
but did show a negative correlation with borderline significance (beta=-0.133,
P=0.075).ConclusionsEyes with a large CD ratio have large and flat corneas; this
may suggest that there is a structural relationship between the cornea and the
optic disc. These results can be helpful in analysing the anatomical
relationship between the cornea and the optic disc.Eye advance online
publication, 23 July 2010; doi:10.1038/eye.2010.98.

PMID: 20651748  [PubMed - as supplied by publisher]

3: Eye (Lond). 2010 Jul 9; [Epub ahead of print] 

Patient, surgical, and lens-related factors, and their association with
Hydroview intraocular lens opacification.

Blundell MS, Mayer EJ, Cartwright NK, Hunt LP, Tole DM, Dick AD.

Academic Unit of Ophthalmology, Department of Clinical Sciences at South
Bristol, University of Bristol, Bristol, UK.

PMID: 20616809  [PubMed - as supplied by publisher]

4: Eye (Lond). 2010 Jun 25; [Epub ahead of print] 

Screening children with NF1 for optic pathway glioma - Yes.

Simmons I, Gogi D.

Department of Ophthalmology, St James's University Hospital, Leeds Teaching
Hospitals NHS Trust, Leeds, UK.

PMID: 20577275  [PubMed - as supplied by publisher]

5: Eye (Lond). 2010 Jun 25; [Epub ahead of print] 

Attitudes of patients and relatives/carers towards genetic testing for inherited
retinal disease.

Bong C, Potrata B, Hewison J, McKibbin M.

Ophthalmology Department, St James's University Hospital, Leeds, UK.

PMID: 20577274  [PubMed - as supplied by publisher]

6: Eye (Lond). 2010 Jun 25; [Epub ahead of print] 

A randomised prospective double-masked exploratory study comparing combination
photodynamic treatment and intravitreal ranibizumab vs intravitreal ranibizumab
monotherapy in the treatment of neovascular age-related macular degeneration.

Vallance JH, Johnson B, Majid MA, Banerjee S, Mandal K, Bailey CC.

Clinical Research Unit, Bristol Eye Hospital, Bristol, UK.

AimsThe aim of this study is to evaluate the effect of standard-fluence
verteporfin photodynamic therapy (PDT) delivered on the first day of a
ranibizumab regimen for choroidal neovascularisation secondary to age-related
macular degeneration compared with ranibizumab monotherapy.MethodsPatients were
randomised to sham or standard-fluence verteporfin PDT at baseline. The first of
three monthly loading doses of ranibizumab was given on the same day, and
thereafter patients received monthly treatment with ranibizumab as required. All
patients underwent monthly visual acuity and OCT assessment and 3-monthly
fluorescein angiography with follow-up to 1 year.ResultsIn all, 18 patients were
recruited. The PDT group gained a mean of 2.2 ETDRS letters at 1 year and the
sham group gained a mean of 4.4 letters (P=0.47). Both groups required a mean of
1.3 injections of ranibizumab following the 3-month loading phase. Fluorescein
angiography at 1 month demonstrated marked choroidal hypoperfusion in all
patients treated with PDT with reduced choroidal perfusion persisting to month
12. This did not occur in the sham group.ConclusionThe addition of
standard-fluence verteporfin PDT at baseline to a ranibizumab regimen conferred
no benefit in terms of visual acuity or number of ranibizumab injections
required at 1 year. The combination of these treatments resulted in persistent
reduced choroidal perfusion, which raises potential safety concerns.Eye advance
online publication, 25 June 2010; doi:10.1038/eye.2010.84.

PMID: 20577273  [PubMed - as supplied by publisher]

7: Eye (Lond). 2010 Jun 25; [Epub ahead of print] 

Efficacy of medical therapy in the initial management of acute primary angle
closure in Asians.

Ramli N, Chai SM, Tan GS, Husain R, Hoh ST, Ho CL, Aung T.

[1] Singapore National Eye Centre and Singapore Eye Research Institute,
Singapore [2] University of Malaya, Kuala Lumpur, Malaysia.

PurposeRecent studies have advocated the use of laser iridoplasty or
paracentesis in the initial management of patients with acute primary angle
closure (APAC). The aim of this study was to ascertain the effectiveness of
medical treatment consisting of topical and systemic intraocular pressure
(IOP)-lowering agents in the initial management of APAC.MethodsThis was an
observational case series of consecutive patients presenting with APAC at a
Singapore hospital over 2 years. On diagnosis, all subjects received intravenous
acetazolamide followed by oral acetazolamide, topical pilocarpine, timolol, and
steroid eye drops. Resolution of APAC was defined as IOP <21 mm Hg with no acute
symptoms.ResultsIn all, 134 consecutive APAC subjects were studied. The majority
of subjects were Chinese (96.3%) and female (80%), and the mean age was
63.7+/-9.6 years. The mean presenting IOP was 58+/-12.7 mm Hg and mean duration
of symptoms was 2.8+/-3.2 days. With medical therapy, APAC attacks resolved
within 3, 6, 12, and 24 h in 28 (21.5%), 58 (44.6%), 99 (76.2%), and 116 (89.2%)
subjects, respectively. After resolution of APAC, laser iridotomy was performed
in 81.6% of the subjects; 16.2% of the subjects underwent cataract extraction.
There was failure of resolution of APAC in only 3 subjects (2.2%). No subject
suffered any serious side effects as a result of treatment.ConclusionsMedical
therapy resulted in resolution of APAC within 12 h in 76.2% of the subjects and
within 24 h in 89.2% of the subjects, showing the effectiveness of medical
therapy in the initial management of APAC.Eye advance online publication, 25
June 2010; doi:10.1038/eye.2010.92.

PMID: 20577272  [PubMed - as supplied by publisher]

8: Eye (Lond). 2010 Jun 25; [Epub ahead of print] 

Effect of lyophilization on the in vitro biological activity of bevacizumab.

Taniwaki L, Mendonca R, Cunha-Junior AS, Faraco AA, Ribeiro JA, Scott IU, Jorge
R.

Department of Ophthalmology, University of Sao Paulo, Ribeirao Preto, Brazil.

PMID: 20577271  [PubMed - as supplied by publisher]

9: Eye (Lond). 2010 Jun 25; [Epub ahead of print] 

Screening children with NF1 for optic pathway glioma - No.

Pilling RF, Taylor RH.

Department of Ophthalmology, Manchester Royal Eye Hospital, Manchester, UK.

PMID: 20577270  [PubMed - as supplied by publisher]

10: Eye (Lond). 2010 Jun 18; [Epub ahead of print] 

Optometrists referrals for glaucoma assessment: a prospective survey of clinical
data and outcomes.

Lockwood AJ, Kirwan JF, Ashleigh Z.

Department of Ophthalmology, Queen Alexandra Hospital, Portsmouth, UK.

AimThe aim of this study is to determine the outcomes following referral for
glaucoma from routine optometric practice and the positive predictive value
(PPV).MethodsA prospective study of 441 referrals for glaucoma in the Portsmouth
area was performed over 6 months. A positive outcome was defined when the
patient had the diagnosis of glaucoma made or if there was a high index of
suspicion of glaucoma requiring follow-up. The PPV was determined from positive
outcome number/referral number.ResultsThe overall PPV was 0.37 (95% confidence
interval 0.33-0.42). Open-angle glaucoma (OAG) was confirmed in 33 (7%)
patients. A diagnosis of ocular hypertension was made in 49 (11%) patients and
glaucoma suspect in 92 (21%) referrals. Two-thirds of optometrists recorded all
3 assessments: fields, intraocular pressure (IOP) and disc appearance, a figure
representing 293 referrals (PPV 0.37). However the greatest referral accuracy
was seen when only discs and IOPs were recorded (PPV 0.47). When all three tests
were given as reasons for suspicion for glaucoma, the PPV was 0.71. The number
of patients diagnosed with OAG from Portsea Island during the study period was
7, whereas the expected number of diagnosed patients was 29.ConclusionWider use
of perimetry by optometrists and increased reporting of all three tests has not
led to an increase in PPV. There remain a considerable number of undiagnosed
patients with glaucoma in the population.Eye advance online publication, 18 June
2010; doi:10.1038/eye.2010.77.

PMID: 20559331  [PubMed - as supplied by publisher]

11: Eye (Lond). 2010 Jun 18; [Epub ahead of print] 

An unusual case of recurrent endogenous Klebsiella endophthalmitis.

Tsai AS, Lee SY, Jap AH.

Department of Ophthalmology, Changi General Hospital, Singapore.

PMID: 20559330  [PubMed - as supplied by publisher]

12: Eye (Lond). 2010 Jul;24(7):1127-34; quiz 1135. Epub 2010 Jun 11. 

Prophylactic laser peripheral iridotomy and cataract progression.

Yip JL, Nolan WP, Gilbert CE, Uranchimeg D, Baassanhuu J, Lee PS, Khaw PT,
Johnson GJ, Foster PJ.

International Centre for Eye Health, London School of Hygiene and Tropical
Medicine, London, UK. jlyy2@medschl.cam.ac.uk

PURPOSE: To determine whether prophylactic laser peripheral iridotomy (LPI) for
primary angle closure (PAC) is associated with cataract progression. METHODS: In
1999, Mongolian volunteers aged>or=50 years were invited to participate in a
longitudinal study. Glaucoma was excluded in all participants and 712 of them
were selected to undergo a full ophthalmic examination as part of the study
protocol. Lenses were graded and PAC diagnosed using international
classification systems. In 2005, all traced participants underwent a similar
dilated examination. Diagnosis of cataract progression was based on the
inter-observer variation +2 standard deviations. The association between LPI at
baseline and cataract progression was assessed using chi2-test and logistic
regression. RESULTS: Of 712 participants, 158 were diagnosed with occludable
angles and treated with LPI. In 2005, 137 participants (19.2%) had died, 315
(315/575=54.8%) were traced, and dilated examination was performed on 276 (48%)
of them. Progression of nuclear opacity (NO), cortical, and posterior
subcapsular (PSC) opacities were evident in 40 (14.5%, 95% confidence interval
(CI)=10.6-19.2%), 89 (32.2%, 95% CI=26.8-38.1%), and 11 participants (4.0%, 95%
CI=2.0-7.0%), respectively. Although NO was more likely to progress in those
with LPI in a crude analysis (odds ratio (OR)=2.02, 95% CI=1.00-4.11, P=0.05),
no evidence of an independent association was detected in multivariate analysis
adjusting for age, sex, and baseline Schaffer grading (adjusted OR=1.24,
0.41-3.75, P=0.7). There was no evidence of an association between LPI and
progression of PSC or cortical opacities. CONCLUSIONS: There is no evidence that
prophylactic LPI is independently associated with cataract progression in this
study.

Publication Types:
    Research Support, Non-U.S. Gov't

PMID: 20539317  [PubMed - in process]

13: Eye (Lond). 2010 Jun 11; [Epub ahead of print] 

An investigation of intraocular lens damage and foreign bodies using an
injectable hydrophilic acrylic lens implant.

Pyott A, Barras C.

Ophthalmology, Raigmore Hospital, Inverness, UK.

PMID: 20539316  [PubMed - as supplied by publisher]

14: Eye (Lond). 2010 Jun 11; [Epub ahead of print] 

The effect on visual function of Hydroview intraocular lens opacification: a
cross-sectional study.

Blundell MS, Mayer EJ, Knox Cartwright NE, Hunt LP, Tole DM, Dick AD.

Department of Clinical Sciences at South Bristol, Academic Unit of
Ophthalmology, University of Bristol, Bristol, UK.

PurposeHydroview intraocular lenses (IOLs) have been associated with symptomatic
opacification of the optic necessitating IOL exchange. Glare and misty vision
have been noted as common presenting symptoms. This study's purpose was to
investigate the impact of IOL opacification on objective measurements of visual
function, including glare, and on vision-related quality of life.MethodsAll
patients who underwent Hydroview IOL implantation at Bristol Eye Hospital
between December 2000 and the end of February 2001 were invited for assessment
along with patients found to have Hydroview IOL opacification in routine
ophthalmic clinics. Glare, visual acuity, contrast sensitivity, visual field,
and colour vision were assessed. Vision-related quality of life and subject's
symptoms were determined by questionnaire. IOL opacification was assessed by
slit lamp bio-microscopy and anterior segment photography.ResultsData from 129
patients were analysed. Fifty subjects had opacified IOLs and 79 clear IOLs.
Subjects with opacified IOLs showed dramatically higher levels of glare
(adjusted mean difference of 0.63 log units 95% CI, 0.45-0.82; P<0.001) with
only mildly reduced visual acuity (adjusted mean difference of 0.09 logMAR units
95% CI, 0.03-0.15; P=0.002). Opacification was associated with poorer contrast
sensitivity (P<0.001), visual field (P<0.001), and with lower vision-related
quality of life (P<0.001).ConclusionsThis study highlights the significant
impact IOL opacification has on visual performance and experience, in particular
glare and consequent impact on quality of life. The study shows that to quantify
accurately the effect of IOL opacification on vision glare must be assessed.Eye
advance online publication, 11 June 2010; doi:10.1038/eye.2010.90.

PMID: 20539315  [PubMed - as supplied by publisher]

15: Eye (Lond). 2010 Jun 11; [Epub ahead of print] 

Incidence of neovascularization in the fellow eye of patients with unilateral
retinal angiomatous proliferation.

Campa C, Harding SP, Pearce IA, Beare NA, Briggs MC, Heimann H.

St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.

AimsThe aim of this study is to describe the incidence and characteristics of
neovascularization in the fellow eye of patients with retinal angiomatous
proliferation (RAP).MethodsThis is a retrospective study conducted on all
patients with a diagnosis of unilateral RAP commencing treatment in a single
centre between November 2002 and January 2010. Clinical biomicroscopic
examination, fluorescein angiography, and if required, indocyanine green
angiography, and optical coherence tomography were used to evaluate all
patients.ResultsIn all, 37 patients had a follow-up of >/=1 year, 28 >/=2 years,
and 11 >/=3. Patients who developed RAP in the fellow eye were: 2 of 37 (5.4%)
within 1 year of follow-up, 4 of 28 (14.2%) within 2 years, and 4 of 11 (36.3%)
within 3 years.ConclusionIn our case series, the risk of neovascularization in
the fellow eye of patients with unilateral RAP increased with time.
Approximately one-third of patients with a 3-year follow-up developed a
bilateral disease. Our findings warrant further large-scale investigation.Eye
advance online publication, 11 June 2010; doi:10.1038/eye.2010.88.

PMID: 20539314  [PubMed - as supplied by publisher]

16: Eye (Lond). 2010 Jun 11; [Epub ahead of print] 

Response to Pyott and Barras.

Harsum S, Mann S, Clatworthy I, Lewin J, Little B.

Department of Ophthalmology, Moorfields Eye Hospital, London, UK.

PMID: 20539313  [PubMed - as supplied by publisher]

17: Eye (Lond). 2010 Jun 4; [Epub ahead of print] 

24-h Intraocular pressures measured with two tonometers.

Weinreb RN, Liu JH, Medeiros FA.

Department of Ophthalmology, Hamilton Glaucoma Center, University of California,
San Diego, La Jolla, CA, USA.

PMID: 20523362  [PubMed - as supplied by publisher]

18: Eye (Lond). 2010 Jun 4; [Epub ahead of print] 

Vitreous traction and epiretinal membranes in diabetic macular oedema using
spectral-domain optical coherence tomography.

Ophir A, Martinez MR, Mosqueda P, Trevino A.

[1] Division of Ophthalmology, Hillel-Yaffe Medical Centre, Hadera, Israel [2]
Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

PurposeThe purpose of this study was to present an association between diabetic
macular oedema (DME) and vitreoretinal interface abnormalities using 3D spectral
domain optical coherence tomography (SD-OCT).MethodsIn a retrospective study,
charts and SD-OCT of consecutive patients with diffuse or focal DME were
reviewed. Only one randomly chosen eye per patient with DME was included, and
eyes that had another retinopathy that could affect the study analysis or that
underwent vitreoretinal surgery were excluded.ResultsOut of 58 eyes (58
patients) with DME, 11 eyes (19.0%) had vitreofoveal traction (Group A), either
unifocally (n=6) or multifocally; that is, associated with additional
extrafoveal traction site(s). Group B comprised 20 eyes (34.5%) that had sole
extrafoveal vitreous traction, at either retinal and/or papillary sites. In
each, the retinal oedema underlying extrafoveal traction was in continuum in at
least one site with that at the central macula, as verified by the macular maps,
thus presented as diffuse macular oedema. In Group C, 13 eyes (22.4%) had an
epiretinal membrane (ERM), 1.5 x 3 mm to >/=6 x 6 mm in size that overlaid
diffuse oedematous macula. Group D included 14 eyes (24.1%) that had neither
vitreous traction nor ERM; 12 (20.7%) of them had DME secondary to leaking
microaneurysms with or without leaking capillary beds, and the remaining two had
leakage from non-microaneurysms sources.ConclusionsDME was detected by the
SD-OCT to be associated with sole extrafoveal vitreous traction in one-third of
the patients. Further studies are required to evaluate the clinical consequences
of these observations.Eye advance online publication, 4 June 2010;
doi:10.1038/eye.2010.80.

PMID: 20523361  [PubMed - as supplied by publisher]

19: Eye (Lond). 2010 Jun 4; [Epub ahead of print] 

Traumatic aniridia and self-sealed globe rupture following blunt trauma.

Sharma V, Mohan M.

Royal Blackburn Hospital, Blackburn, UK.

PMID: 20523360  [PubMed - as supplied by publisher]

20: Eye (Lond). 2010 Jun 4; [Epub ahead of print] 

Response to Weinreb et al.

Stewart WC, Konstas AG, Quaranta L, Rossetti L, Garcia-Feijoo J, O'Brien C, Nasr
MB, Fogagnolo P, Demos CM, Stewart JA.

PRN Pharmaceutical Research Network, LLC, Charleston, SC, USA.

PMID: 20523359  [PubMed - as supplied by publisher]

21: Eye (Lond). 2010 Jun 4; [Epub ahead of print] 

Sutureless and glue-free conjunctival autograft in pterygium surgery: a case
series.

de Wit D, Athanasiadis I, Sharma A, Moore J.

Department of Ophthalmology, Addenbrookes Hospital, Cambridge, UK.

AimsForeign materials used in ocular surface surgery may lead to local
complications such as discomfort, scarring, or infection. Plasma-derived
products such as fibrin glue may produce possible hypersensitivity reactions
whereas the risk of viral transmission remains. We describe a simple method of
achieving conjunctival autograft adherence during pterygium surgery avoiding
potential complications associated with the use of fibrin glue or
sutures.MethodsAfter pterygium excision and fashioning of the autologous
conjunctival graft, the recipient bed is encouraged to achieve natural
haemostasis and relative dessication before graft placement. Excessive
haemorrhage in the graft bed is tamponaded. Graft adherence and positioning is
examined 20 min after surgery.ResultsA total of 15 eyes of 12 patients (mean
(SD) age 73.7 (11.2) years), 8 females underwent SGF autologous conjunctival
graft post-pterygium excision. Mean graft area was 24(1.5) mm(2). Mean follow-up
time was 9.2 (2.2) months. Cosmesis was excellent in all cases and visual acuity
improved in one patient. There were no intra- or post-operative complications
requiring further treatment.ConclusionThis simple technique for pterygium
surgery may prevent potential adverse reactions encountered with the use of
foreign materials and in this small series provided safe and comparable results
to current methods.Eye advance online publication, 4 June 2010;
doi:10.1038/eye.2010.75.

PMID: 20523358  [PubMed - as supplied by publisher]

22: Eye (Lond). 2010 Jun 4; [Epub ahead of print] 

Agreement between image grading of conventional (45 degrees ) and ultra
wide-angle (200 degrees ) digital images in the macula in the Reykjavik eye
study.

Csutak A, Lengyel I, Jonasson F, Leung I, Geirsdottir A, Xing W, Peto T.

[1] Moorfields Eye Hospital, London, England [2] University of Debrecen Medical
and Health Science Centre, Debrecen, Hungary.

PurposeTo establish the agreement between image grading of conventional (45
degrees ) and ultra wide-angle (200 degrees ) digital images in the
macula.MethodsIn 2008, the 12-year follow-up was conducted on 573 participants
of the Reykjavik Eye Study. This study included the use of the Optos P200C AF
ultra wide-angle laser scanning ophthalmoscope alongside Zeiss FF 450
conventional digital fundus camera on 121 eyes with or without age-related
macular degeneration using the International Classification System. Of these
eyes, detailed grading was carried out on five cases each with hard drusen,
geographic atrophy and chorioretinal neovascularisation, and six cases of soft
drusen. Exact agreement and kappa-statistics were calculated.ResultsComparison
of the conventional and ultra wide-angle images in the macula showed an overall
96.43% agreement (kappa=0.93) with no disagreement at end-stage disease;
although in one eye chorioretinal neovascularisation was graded as drusenoid
pigment epithelial detachment. Of patients with drusen only, the exact agreement
was 96.1%. The detailed grading showed no clinically significant disagreement
between the conventional 45 degrees and 200 degrees images.ConclusionsOn the
basis of our results, there is a good agreement between grading conventional and
ultra wide-angle images in the macula.Eye advance online publication, 4 June
2010; doi:10.1038/eye.2010.85.

PMID: 20523357  [PubMed - as supplied by publisher]

23: Eye (Lond). 2010 Jun 4; [Epub ahead of print] 

Unique phenotype in a Chinese family pedigree: ectopia lentis with varicose
great saphenous vein.

Shen W, Fu Q, Sui R, Wu J, Liu L.

Department of Ophthalmology, First Affiliated Hospital of Second Military
Medical University, Shanghai, China.

ObjectiveTo report a Chinese family affected with both ectopia lentis and
varicose great saphenous vein.DesignObservational pedigree
report.ParticipantsThe family with a total of 53 members in five generations. In
the kindred there were 16 affected adults (including 6 deceased), of which 7
were male and 9 were female.Main outcome measuresPatients in this family showed
an autosomal dominant trait of ectopia lentis and varicose great saphenous vein,
occurring in four successive generations. The onset ages for lens dislocation
were between 38 and 52 years. No cardiovascular abnormality was observed. Four
patients underwent intracapsular lens extraction surgery.ConclusionsThe
phenotype of this family showed similarities with Marfan-related disorders. This
is a unique phenotype of ectopia lentis with varicose great saphenous vein.Eye
advance online publication, 4 June 2010; doi:10.1038/eye.2010.82.

PMID: 20523356  [PubMed - as supplied by publisher]

24: Eye (Lond). 2010 May 28; [Epub ahead of print] 

Bilateral disc swelling associated with posterior scleritis.

Stead RE, Mokashi A, Subramaniam S.

Department of Ophthalmology, Kings Mill Hospital, Mansfield, Nottinghamshire,
UK.

PMID: 20508658  [PubMed - as supplied by publisher]

25: Eye (Lond). 2010 May 28; [Epub ahead of print] 

The reuse of ophthalmic minims: an unacceptable cross-infection risk?

Yap YC, Smith M, Byles D.

Glaucoma Unit, West of England Eye Unit, Royal Devon and Exeter Hospital,
Exeter, UK.

PMID: 20508657  [PubMed - as supplied by publisher]

26: Eye (Lond). 2010 May 28; [Epub ahead of print] 

Response to 'Bilateral disc swelling: papillitis or posterior scleritis?'

Sandfeld L, Petersen E, Sousa S, Laessoe M, Milea D.

Eye Clinic, Rigshospitalet, Copenhagen, Denmark.

PMID: 20508656  [PubMed - as supplied by publisher]

27: Eye (Lond). 2010 May 28; [Epub ahead of print] 

Trends in the rate of trabeculectomy.

Tatham A, Sarodia U.

Department of Ophthalmology, University Hospitals Leicester, Leicester, UK.

PMID: 20508655  [PubMed - as supplied by publisher]

28: Eye (Lond). 2010 May 28; [Epub ahead of print] 

A glaucoma equity profile: correlating disease distribution with service
provision and uptake in a population in Northern England, UK.

Day F, Buchan JC, Cassells-Brown A, Fear J, Dixon R, Wood F.

Public Health, NHS Yorkshire and Humber, Leeds, UK.

AimsGlaucoma is a significant health problem, with associated inequalities.
Equity profiles are an established public health tool to examine the scale of
health inequalities and to imbed action into the commissioning cycle. This is
the first equity profile conducted in the United Kingdom for an ophthalmic
condition. This methodology also provides a model for use in other localities
and for other eye conditions.MethodsExisting services were mapped and need
identified. A wide variety of data sources were analysed. Mapping was undertaken
using Mapinfo Professional Geographical Information Systems software.
Statistical analysis was conducted using Microsoft Excel 2003.ResultsNo single
data source provided a fully informed perspective. A clear mismatch between
areas of deprivation and location of optometry was observed. Secondary analysis
of electronic patient records revealed a significant association between 'late
presentation' and older age (mean age of late presenters=76.4 years, 95%
CI=75.1-77.6 compared with earlier presenters, 72.4 years, 95% CI=71.7-73.1).
Late presentation was also associated with living in an area of high deprivation
(chi(2)=7.1, 1df, P<0.05). Ethnicity data was poorly recorded. Qualitative data
provided invaluable insights.ConclusionsIncreasing access to services involves
collaboration with optometrists, ophthalmologists, public health, and
commissioners. It is no longer acceptable to rely on private high street
optometry to provide primary eye care services in areas of high need. Outreach
services must be developed and evaluated in areas of relative deprivation if
world class eye services are to be achieved.Eye advance online publication, 28
May 2010; doi:10.1038/eye.2010.73.

PMID: 20508654  [PubMed - as supplied by publisher]

29: Eye (Lond). 2010 May 28; [Epub ahead of print] 

Influence of pupil dilation on retinal nerve fibre layer measurements with
spectral domain OCT.

Massa GC, Vidotti VG, Cremasco F, Lupinacci AP, Costa VP.

Department of Ophthalmology, University of Campinas, Campinas, Brazil.

PurposeTo evaluate the influence of pupil dilation on retinal nerve fibre layer
(RNFL) measurements with spectral domain optical coherence tomography
(OCT).Patients and MethodsIn total, 29 healthy individuals and 26 glaucoma
patients underwent RNFL measurements with the Cirrus HD-OCT Model 4000 (Carl
Zeiss Meditec Inc.) before and 30-40 min after pupil dilation with one drop of
tropicamide 1%. Average thickness, quadrant thickness, and clock-hour thickness
measurements were compared with the paired Student's t-test. We also compared
the quality scores of the images obtained pre- and post-pupil
dilation.ResultsMean ages in the glaucoma and control groups were 58.3+/-13.4
and 41.6+/-16.4 years respectively (P<0.001). Mean deviation values were
-6.96+6.31 dB in the glaucoma group and -1.26+0.79 dB in the control group
(P<0.001). Mean RNFL measurements obtained in the glaucoma group were
significantly lower than those obtained in the control group (P<0.001). There
were no statistically significant differences between mean quality scores
obtained before and after dilation neither in the glaucoma group (7.73+/-0.92
vs7.54+/-1.10, P=0.232) nor in the control group (8.14+/-0.88 vs8.00+/-0.71,
P=0.380). There was no statistically significant difference between mean RNFL
measurements obtained pre- and post-pupil dilation neither among normal
individuals (P>0.05), nor among glaucoma patients (P>0.05).ConclusionThe results
of this study indicate that RNFL measurements obtained with spectral domain OCT
are not influenced by pupil size.Eye advance online publication, 28 May 2010;
doi:10.1038/eye.2010.72.

PMID: 20508653  [PubMed - as supplied by publisher]

30: Eye (Lond). 2010 May 28; [Epub ahead of print] 

Evaluation of agreement between intraocular pressure measurements using Goldmann
applanation tonometry and Goldmann correlated intraocular pressure by Reichert's
ocular response analyser.

Ehrlich JR, Haseltine S, Shimmyo M, Radcliffe NM.

Department of Ophthalmology, Weill Cornell Medical College, New York, NY, USA.

PurposeTo compare agreement of intraocular pressure (IOP) measurements using
Goldmann applanation tonometry (GAT) and Goldmann correlated intraocular
pressure generated (IOPg) by the Reichert ocular response analyser
(ORA).MethodsConsecutive patients presenting for glaucoma evaluation underwent
ORA assessment followed by examination including GAT. For each ORA assessment,
measurements were taken until a waveform score (WS) of 6.5 was obtained or until
five measurements were obtained per eye. The relationship between GAT and IOPg
and the influence of the WS upon this relationship was evaluated. A Bland-Altman
plot and linear regression were used to determine agreement between GAT and
IOPg.ResultsA total of 518 eyes of 260 patients were included in the final
analysis. Increasing WS was found to predict a smaller difference between GAT
and IOPg (beta=-0.2, PPMID: 20508652  [PubMed - as supplied by publisher]