1: Can J Ophthalmol. 2011 Nov-Dec;46(6 Suppl):S1-21. Epub 2011 Nov 1. 

Comment in:
    Can J Ophthalmol. 2011 Dec;46(6):462-4.
    Can J Ophthalmol. 2011 Dec;46(6):465-7.

Model of interprofessional collaboration in the care of glaucoma patients and
glaucoma suspects.

[Article in English, French]

Canadian Glaucoma Society Committee on Interprofessional Collaboration in
Glaucoma Care.

PMID: 22153711  [PubMed - in process]

2: Can J Ophthalmol. 2011 Dec;46(6):556-7. 

Endogenous bacterial endophthalmitis after routine colonoscopy.

Wu AY, Oestreicher JH.

Publication Types:
    Letter

PMID: 22153651  [PubMed - in process]

3: Can J Ophthalmol. 2011 Dec;46(6):555-6. 

Oblique illumination and trypan blue to enhance visualization through corneal
scars in cataract surgery.

Habeeb SY, Varma DK, Ahmed II.

Publication Types:
    Letter

PMID: 22153650  [PubMed - in process]

4: Can J Ophthalmol. 2011 Dec;46(6):553-4. 

Persistent eyelid swelling in a child caused by Cuterebra myiasis.

Grzyb MJ, Belliveau MJ, Kratky V.

Publication Types:
    Letter

PMID: 22153649  [PubMed - in process]

5: Can J Ophthalmol. 2011 Dec;46(6):552-3. 

Comment on:
    Can J Ophthalmol. 2010 Jun;45(3):286-7.

Acute orbital inflammatory syndrome following H1N1 immunization.

Belliveau MJ, Kratky V, Evans GA, Almeida DR, El-Defrawy S.

Publication Types:
    Comment
    Letter

PMID: 22153648  [PubMed - in process]

6: Can J Ophthalmol. 2011 Dec;46(6):551-2. 

Choroidal metastasis from a mediastinal choriocarcinoma in a male.

Krema H, Navajas E, Simpson ER, Payne D.

Publication Types:
    Letter

PMID: 22153647  [PubMed - in process]

7: Can J Ophthalmol. 2011 Dec;46(6):549-51. 

Can genetic factors predict response to antivascular endothelial growth factor
therapy in age-related macular degeneration?

Micieli JA.

Publication Types:
    Letter

PMID: 22153646  [PubMed - in process]

8: Can J Ophthalmol. 2011 Dec;46(6):548. 

Comment on:
    Can J Ophthalmol. 2011 Jun;46(3):221-4.

RE: Ocular treatment of diabetic macular edema in Canada: where are we going?

Noble J, Kertes PJ.

Publication Types:
    Comment
    Letter

PMID: 22153645  [PubMed - in process]

9: Can J Ophthalmol. 2011 Dec;46(6):543-7. 

Spectral-domain optical coherence tomography for early glaucoma assessment:
analysis of macular ganglion cell complex versus peripapillary retinal nerve
fiber layer.

Moreno PA, Konno B, Lima VC, Castro DP, Castro LC, Leite MT, Pacheco MA, Lee JM,
Prata TS.

Hospital Medicina dos Olhos, Sao Paulo, Brazil; Federal University of Sao Paulo,
Sao Paulo, Brazil.

OBJECTIVE: We sought to compare the glaucoma discrimination ability of macular
inner retinal layer (MIRL) thickness with that of conventional peripapillary
retinal nerve fiber layer (pRNFL) thickness as measured by spectral-domain
optical coherence tomography (SD-OCT) in patients with early glaucoma. DESIGN:
Cross-sectional study. PARTICIPANTS: We studied 67 patients with early glaucoma
(visual field mean deviation index >/=-6 dB), and 56 healthy subjects were
prospectively enrolled. METHODS: All patients underwent MIRL thickness
measurement (ganglion cell complex [GCC] scan) and pRNFL thickness measurement
(3.45 mm scan) by SD-OCT. Whenever both eyes were eligible, one was randomly
selected. Receiver operating characteristic curves and sensitivities at fixed
specificities were generated for different parameters. The areas under the
receiver operating characteristic curves (AUCs) of each parameter were compared.
RESULTS: The average mean deviation for the glaucomatous eyes was -2.5 +/- 1.6
dB. The AUCs for average (0.815); superior (0.807); and inferior (0.788) MIRL
thicknesses were not significantly different (p >/= 0.18). The AUCs for average
(0.735); superior (0.728); and inferior (0.697) pRNFL thicknesses were also
similar (p >/= 0.15). Average MIRL thickness had a significantly larger AUC
compared to average pRNFL thickness analysis (0.815 vs 0.735; p = 0.03).
Sensitivities at 80% specificity for average MIRL and pRNFL thicknesses were
66.7% (cutoff, 89.9 mum) and 62.9% (cutoff, 111.8 mum), respectively.
CONCLUSIONS: The GCC scan showed a similar or even a slightly better ability to
discriminate between healthy and early glaucomatous eyes compared to the pRNFL
scan. Different from previous analyses considering total macular thickness, the
GCC macular scan seems to be a useful tool for identification of early
structural damage in patients with glaucoma. Copyright (c) 2011 Canadian
Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

PMID: 22153644  [PubMed - in process]

10: Can J Ophthalmol. 2011 Dec;46(6):537-42. 

Bleb needling with subconjunctival injection of sodium hyaluronate 1.4%: 1-year
outcomes.

Shafi F, Agrawal P, Holder R, Sung V.

Birmingham and Midland Eye Centre, Sandwell and West Birmingham NHS Trust,
Birmingham, UK.

OBJECTIVES: To assess the safety and efficacy of 5-fluorouracil (5-FU)-augmented
bleb needling revision (BNR) with subconjunctival Healon GV (sodium hyaluronate
1.4%) over a 12-month follow-up. DESIGN: Retrospective consecutive case series.
PARTICIPANTS: We studied 54 patients who had undergone primary BNR with
adjunctive 5-FU and routine subconjunctival Healon GV between 2004 and 2007.
METHODS: BNR was performed using multiple puncturing motions through the bleb: a
0.4 mL Healon GV injection between the bleb and conjunctiva; and a 5-FU (10 mg
in 0.4 mL) injection into the substance of Healon GV. Success was defined as
follows: (1) complete success, indicating intraocular pressure (IOP) reduction
>/= 20% and to  5 mm Hg without antiglaucoma medication; or
(2) qualified success, indicating IOP reduction >/= 20% and to  5 mm Hg with or without antiglaucoma medication. Patients requiring additional
filtration surgery during the 12-month follow-up period were considered
failures. RESULTS: Data collection was completed for 53 eyes of 46 patients. The
IOP fell from a preoperative mean of 22.7 +/- 7.95 mm Hg to 16.3 +/- 4.34 mm Hg
at 12 months (p < 0.001). The complete success rate was 26.4%; the qualified
success rate was 43.4%. Of the eyes studied, 28 (52.8%) achieved IOPs of PMID: 22153643  [PubMed - in process]

11: Can J Ophthalmol. 2011 Dec;46(6):531-6. 

Evaluation of investigator bias in industry-funded clinical trials of
latanoprost.

Jinapriya D, Anraku A, Alasbali T, Trope GE, Buys YM.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto,
Ontario.

OBJECTIVE: To determine whether sponsorship of prostaglandin analogue (PGA)
clinical trials results in investigator bias in outcomes when studying
intraocular pressure (IOP). DESIGN: Retrospective, observational cohort study.
METHODS: A PubMed search was performed for latanoprost or Xalatan, bimatoprost
or Lumigan, and travoprost or Travatan, with limits to humans, clinical trials,
and English language. Inclusion criteria included randomized controlled trials,
open-angle glaucoma, monotherapy with a PGA, baseline IOP >/= 21 mm Hg, washout
period, and minimum 1-month follow-up. Each article was reviewed by 2
independent reviewers. The results of IOP for each PGA were categorized as being
sponsored by the parent company (the company manufacturing the PGA); by the
competing company (the company manufacturing competing glaucoma therapy); or by
a nonindustry source. The mean IOP and changes in IOP from baseline were
compared among the 3 categories of sponsorship. RESULTS: Only studies involving
latanoprost were analyzed because of the low number of studies meeting the
inclusion criteria for bimatoprost and travoprost. We found 29 and 13 studies
that provided 1- and 3-month data, respectively, for analysis. The mean baseline
IOPs in the 3 groups (parent company, competing company, nonindustry) were not
significantly different (p = 0.47). The mean IOP at 1 (p = 0.72) and 3 months (p
= 0.59) and the change in IOP from baseline (p = 0.83 and 0.90, respectively)
were not significantly different in the 3 groups. A random-effects
metaregression controlling for the covariates of blinding, naivete to PGAs, and
baseline IOP < 24 mm Hg or >/= 24 mm Hg did not change the findings. CONCLUSION:
There was no evidence of investigator bias in determining outcomes for IOP in
these clinical trials of latanoprost. Copyright (c) 2011 Canadian
Ophthalmological Society. Published by Elsevier Inc. All rights reserved.

Publication Types:
    Research Support, Non-U.S. Gov't

PMID: 22153642  [PubMed - in process]

12: Can J Ophthalmol. 2011 Dec;46(6):528-30. Epub 2011 Jul 7. 

Clopidogrel therapy in ophthalmic procedures: a survey of subspecialty
ophthalmologists and review of current guidelines.

Hess TM, Liu ES.

The University of Toronto Department of Ophthalmology & Vision Sciences,
Toronto, Ont. tiiu.hess@utoronto.ca

OBJECTIVE: To assess the knowledge and practice of subspecialty ophthalmologists
with respect to perioperative clopidogrel therapy in ophthalmic procedures.
DESIGN: Mail survey composed of 5 questions. PARTICIPANTS: Fifteen subspecialty
ophthalmologists (3 in each of the fields of surgical retina, anterior segment,
oculoplastics, strabismus, and glaucoma) in 3 academic centers in Toronto,
Ontario. METHODS: Study parcipants completed an anonymous mail survey consisting
of multiple-choice and short-answer questions. We studied participants'
knowledge about and clinical practices regarding the use of clopidogrel in the
perioperative period of specified ophthalmic procedures. We evalutated perceived
risks of halting clopidogrel indicated for both primary and secondary prevention
of cardiovascular events, as well as clinical decisions regarding clopidogrel in
the perioperative period of specified ophthalmic procedures. RESULTS: There was
marked variability and relative lack of knowledge by subspecialty
ophthalmologists in the management of clopidogrel in the perioperative period.
Only 1 respondent identified coronary stent thrombosis or restenosis as a
potential and life-threatening risk of halting clopidogrel therapy in these
patients. CONCLUSIONS: In patients with coronary stents, the risks of halting
clopidogrel therapy in the perioperative period are potentially life-threatening
and include stent thrombosis and myocardial infarction. Ophthalmic surgeons
should pay close attention to the indications for clopidogrel therapy in their
patients and should enlist appropriate collaboration with their colleagues in
cardiology to minimize risks to their patients. Crown Copyright (c) 2011.
Published by Elsevier Inc. All rights reserved.

PMID: 22153641  [PubMed - in process]

13: Can J Ophthalmol. 2011 Dec;46(6):521-7. 

A meta-analysis of primary dacryocystorhinostomy with and without silicone
intubation.

Feng YF, Cai JQ, Zhang JY, Han XH.

The Affiliated Eye Hospital of Wenzhou Medical College, Zhejiang, China.

OBJECTIVE: To examine possible differences in success rates of primary
dacryocystorhinostomy (DCR) with and without silicone intubation, and to find
out whether the use of silicone tubes is beneficial. DESIGN: A literature search
was conducted in the PubMed, EMBASE, and Cochrane Controlled Trials Register to
identify potentially relevant controlled trials. METHODS: Language was
restricted to English. The surgical techniques were categorized into external
DCR (EX-DCR), endonasal laser-assisted DCR (LA-DCR), and nonlaser endoscopic
endonasal DCR techniques (EN-DCR). The main outcome measure was success rates
after DCR-with and DCR-without silicone intubation. The statistical analysis was
carried out using a RevMan 5.0 software. RESULTS: Of 188 retrieved trials from
the electronic database, 9 trials (5 randomized controlled trials and 4 cohort
studies) involving 514 cases met our inclusion criteria. There was no
statistically significant heterogeneity between the studies. The pooled risk
ratio was 0.99, with a 95% confidence interval (0.91-1.08). There was no
significant difference in the success rates between the DCR with and without
silicone intubation (p = 0.81). Sensitivity analysis and subgroups analyses
suggested that the result was comparatively reliable. CONCLUSIONS: Based on this
meta-analysis that included 5 randomized controlled trials and 4 cohort studies,
no benefit was found for silicone tube intubation in primary DCR. Further
well-organized, prospective, randomized studies involving larger patient numbers
are required. Copyright (c) 2011 Canadian Ophthalmological Society. Published by
Elsevier Inc. All rights reserved.

PMID: 22153640  [PubMed - in process]

14: Can J Ophthalmol. 2011 Dec;46(6):513-20. 

In vitro comparison of the cytotoxic effects of clinically available ophthalmic
solutions of fluoroquinolones on human keratocytes.

Mencucci R, Paladini I, Pellegrini-Giampietro DE, Menchini U, Scartabelli T.

Department of Oto-Neuro-Ophthalmological Surgical Sciences, University of
Florence, Florence, Italy.

OBJECTIVE: To compare the cytotoxic effects of preserved versus unpreserved
commercially available ophthalmic preparations of fluoroquinolones on human
keratocytes in vitro. DESIGN: Experimental study. METHODS: Human keratocytes in
vitro were incubated for 15 or 60 minutes with commercially available
preparations containing different types of fluoroquinolones, with or without
benzalkonium chloride. We examined the morphologic aspects of the cultures by an
inverted-phase contrast microscope and the release of cytoplasmic enzyme lactate
dehydrogenase into the medium immediately or 24 hours after exposure to drugs.
RESULTS: Whereas preparations of ofloxacin, norfloxacin, and gatifloxacin, all
containing benzalkonium chloride, and moxifloxacin, which is preservative-free,
displayed various degrees of cytotoxicity in our model, the unpreserved monodose
preparation of norfloxacin was virtually devoid of harmful effects under our
experimental conditions. CONCLUSIONS: Our in vitro results indicated the
cytotoxic role of preservatives in commercial preparations of fluoroquinolones
and the relative nontoxicity of monodose unpreserved norfloxacin, even when
keratocytes were incubated with this formulation for 6 hours. Copyright (c) 2011
Canadian Ophthalmological Society. Published by Elsevier Inc. All rights
reserved.

Publication Types:
    Research Support, Non-U.S. Gov't

PMID: 22153639  [PubMed - in process]

15: Can J Ophthalmol. 2011 Dec;46(6):510-2. 

Error of calibration in ophthalmic calipers: a source of significant clinical
errors.

Dahrab MM, Laroche GR.

Dalhousie University, Halifax, NS.

OBJECTIVE: Length measuring instruments are frequently used in ophthalmic
surgery practice. For all subspecialties, calipers need to be accurate. This
study was carried out to identify errors of calibration in ophthalmic calipers
as a potential source of significant clinical errors. DESIGN: This study is a
descriptive research. METHODS: All Castroviejo calipers free of any visible
damage and available to the ophthalmic surgeons in the operating room suites of
our 2 affiliated hospitals were included. The caliper scale readings were
compared to measurement markings on a standardized ruler at screening points of
1, 5, 10, and 15 mm on the ruler. Any caliper with a discrepancy of 0.5 mm or
more at any set of these screening points went on to having further analysis.
RESULTS: Seventy-one calipers were examined, of which 30 (42%) showed at least 1
caliper scale reading discrepancy of >/=0.5 mm as compared to ruler
measurements. Errors of at least 1 mm were found in 6 of 30 calipers (20%). The
majority of calipers underestimated lengths 22/30 (73%), whereas 27%
overestimated. CONCLUSIONS: With close to half of the calipers inducing a 0.5 mm
or more error, and with 20% of these at least 1 mm, significant clinical
consequences could ensue: for example, in follow up of glaucomatous corneas in
children, in measurements for anterior chamber intraocular lens sizing, in
certain refractive surgery techniques, pars-plana sclerotomies, and intravitreal
injection sites, or in measuring amounts in strabismus to name a few. Errors in
calibration of ophthalmic calipers must be acknowledged and avoided. Copyright
(c) 2011 Canadian Ophthalmological Society. Published by Elsevier Inc. All
rights reserved.

PMID: 22153638  [PubMed - in process]

16: Can J Ophthalmol. 2011 Dec;46(6):501-9. 

Slipped, severed, torn and lost extraocular muscles.

Cherfan CG, Traboulsi EI.

Department of Ophthalmology, American University of Beirut Medical Center,
Beirut, Lebanon.

Slipped, severed, torn and lost extraocular muscles (EOM) are infrequently
encountered in clinical practice but constitute significant complications of
strabismus and other eye surgery and of orbital injuries. Knowledge of the
clinical aspects of these various disease entities and their anatomical
underpinnings are of utmost importance in providing effective recognition and
treatment. These conditions share some common presenting signs, symptoms and
clinical findings that are discussed in this review. The literature will be
reviewed and management strategies will be presented. Copyright (c) 2011
Canadian Ophthalmological Society. Published by Elsevier Inc. All rights
reserved.

PMID: 22153637  [PubMed - in process]

17: Can J Ophthalmol. 2011 Dec;46(6):498-500. 

Spectral domain optical coherence tomography findings in acute retinal pigment
epitheliitis.

Cho HJ, Lee DW, Kim CG, Kim JW.

Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of
Medicine, Seoul, Korea. ccnnrr@naver.com

OBJECTIVE: To report spectral domain optical coherence tomography (SD-OCT)
findings in 3 patients with acute retinal pigment epitheliitis (ARPE). DESIGN:
Retrospective chart review. METHODS: Charts of three young patients with ARPE
were reviewed. RESULTS: In acute stage, SD-OCT demonstrated abnormal
hyperreflectivity involving the photoreceptor outer segment layer and
hyporeflectivity involving the associated RPE layer in all cases. In chronic
stage, SD-OCT showed decreased abnormal reflectivity. In one case with
incomplete recovery of visual acuity, disruption of the photoreceptor inner and
outer segment (IS/OS) junction was demonstrated in chronic phase. CONCLUSIONS:
SD-OCT confirmed that the outer segments of foveal photoreceptors and the
associated RPE layer were the primary affected sites with ARPE. Detection of
integrity of the foveal IS/OS line in resolved ARPE could be helpful in
prediction of visual prognosis. Copyright (c) 2011 Canadian Ophthalmological
Society. Published by Elsevier Inc. All rights reserved.

PMID: 22153636  [PubMed - in process]

18: Can J Ophthalmol. 2011 Dec;46(6):491-7. 

Macular structure on optical coherence tomography after lamellar macular hole
surgery and its correlation with visual outcome.

Figueroa MS, Noval S, Contreras I.

Vissum Premium Mirasierra, Madrid, Spain.

OBJECTIVE: To report macular structure on optical coherence tomography (OCT)
after lamellar macular hole surgery and its relationship with visual outcome.
DESIGN: Retrospective interventional case series; private practice setting.
PARTICIPANTS: Twelve patients diagnosed with a lamellar hole who had undergone
vitrectomy and who had OCT scanning before and after surgery and at least 6
months follow-up were included. METHODS: Surgery consisted of 25 g vitrectomy,
peeling of epiretinal and internal limiting membrane, fluid/air/gas exchange,
and 2 weeks of face-down positioning. RESULTS: OCT showed an epiretinal membrane
in all cases. After a mean follow-up of 16.7 months, VA improved by >/=2 lines
in nine patients and remained stable in three. There was a complete closure of
the lamellar hole in ten patients; in four a retinal pseudocyst was found during
the healing process, resolving spontaneously in two and persisting in the other
two after 8 and 9 months, respectively. Two patients developed a full-thickness
macular hole that closed successfully after surgical repair. All patients had a
VA >/= 20/32 at the end of follow-up. CONCLUSION: Epiretinal membranes appear to
have a role in the pathogenesis of lamellar macular holes. Vitrectomy is a
useful technique to obtain closure of the lamellar hole and visual improvement.
The presence of a retinal pseudocyst is a common feature during the healing
process and is compatible with a favorable visual outcome. A full-thickness
macular hole is a severe and not uncommon complication of this procedure.
Copyright (c) 2011 Canadian Ophthalmological Society. Published by Elsevier Inc.
All rights reserved.

PMID: 22153635  [PubMed - in process]

19: Can J Ophthalmol. 2011 Dec;46(6):486-90. 

Recurrence of macular edema in retinal vein occlusions after treatment with
intravitreal ranibizumab (Lucentis).

Karagiannis DA, Karampelas MD, Soumplis VM, Amariotakis C, Georgalas I,
Kandarakis A.

Ophthalmiatrion Eye Hospital of Athens, Athens, Greece.

OBJECTIVE: To evaluate the recurrence of macular edema (ME) in a mixed group of
patients with branch (BRVO) and central (CRVO) retinal vein occlusion after
early onset treatment with intravitreal injections of ranibizumab. DESIGN:
Nonrandomized, uncontrolled prospective clinical trial. PARTICIPANTS: Forty
patients were enrolled in our study. Twenty-two patients had BRVO and 18
patients had CRVO. METHODS: All patients had a minimum follow-up of 12 months.
All patients had fundus fluorescein angiography (FFA) and optical coherence
tomography (OCT) at presentation. The time period between RVO occurrences and
initial examination and treatment was <1 month. Every patient was treated with 2
consecutive intravitreal injections of ranibizumab (0.5 mg) 1 month apart.
Assessment was carried out on a monthly basis and injection was carried out if
necessary, based on OCT findings. RESULTS: Recurrence of ME occurred in 13
patients (13/22, 59%) in the BRVO group, whereas in the CRVO group occurred in
all patients (18/18, 100%). Mean time interval of these recurrences from last
injection was 2.4 months and 1.2 months for BRVO and CRVO groups, respectively.
Mean period of ME reabsorption was 2.5 months for the BRVO group and 3.5 months
for the CRVO group. CONCLUSIONS: Recurrent ME occurred in 77.5% of our patients.
These recurrences occurred sooner, were more prominent and lasted longer in
patients with CRVO. Copyright (c) 2011 Canadian Ophthalmological Society.
Published by Elsevier Inc. All rights reserved.

PMID: 22153634  [PubMed - in process]

20: Can J Ophthalmol. 2011 Dec;46(6):481-5. 

Predicting retinal tears in posterior vitreous detachment.

Schweitzer KD, Eneh AA, Hurst J, Bona MD, Rahim KJ, Sharma S.

Department of Ophthalmology, Queen's University, Kingston, Ont.

OBJECTIVE: The purpose of this study is to determine whether patients with acute
posterior vitreous detachment (PVD) who develop delayed retinal tears within the
first 6 weeks after initial presentation have predictive characteristics.
DESIGN: Prospective cohort study. PARTICIPANTS: All patients presenting to the
Hotel Dieu Hospital Emergency Eye Clinic between September 2008 and July 2009
diagnosed with acute PVD were offered enrollment. METHODS: At the initial visit,
patients were given the previously validated Queen's University Posterior
Vitreous Detachment Patient Diary to record their daily symptoms for 6 weeks.
Two or 6 weeks later, patients were reexamined in detail, and their diaries were
collected and analyzed. Exact logistic regression was used to establish
characteristics predictive of delayed retinal tears. RESULTS: In our study
population of 99 patients, 2 developed delayed retinal tears. One had retinal
hemorrhages and the other had a cloud-like floater at initial presentation.
Vitreal or retinal hemorrhage, large number of floaters at initial presentation,
and high floater frequency at initial presentation indicated a high risk of
delayed retinal tear formation, yielding a median unbiased estimated odds ratio
of 36.18 with p value 0.009. No other presenting risk factors or symptomatology
followed daily over the first 6 weeks after acute PVD were predictive of delayed
retinal tear formation. CONCLUSIONS: PVD patients with retinal or vitreal
hemorrhage, a significant number of floaters or a cloud like appearance to the
floaters, or high floater frequency are at higher risk of developing delayed
retinal tears. Copyright (c) 2011 Canadian Ophthalmological Society. Published
by Elsevier Inc. All rights reserved.

PMID: 22153633  [PubMed - in process]

21: Can J Ophthalmol. 2011 Dec;46(6):477-80. 

When straight eyes won't move: phenotypic overlap of genetically distinct ocular
motility disturbances.

Oystreck DT, Salih MA, Bosley TM.

Department of Ophthalmology, College of Medicine, King Saud University, Riyadh,
Saudi Arabia. darrenoystreck@ymail.com

OBJECTIVE: To describe the phenotypic similarity in a series of patients with
genetically distinct ocular motility disturbances involving straight eyes and
different ocular motor pathology. DESIGN: Retrospective case series.
PARTICIPANTS: Clinical and genetic evaluation of 5 patients with straight eyes
in the primary position and abnormalities of ocular motility. RESULTS: Patients
with oculopharyngeal muscular dystrophy, congenital myasthenic syndrome,
congenital fibrosis of the extraocular muscles type 3, Bosley-Salih-Alorainy
syndrome, and horizontal gaze palsy and progressive scoliosis all had straight
eyes in primary position and restricted ocular motility. History, ocular
motility patterns, systemic features of individual syndromes, and genetic
screening were important diagnostically. CONCLUSIONS: A number of congenital and
genetic ocular motility syndromes may result in substantial phenotypic overlap,
particularly when eyes are straight in primary position and nonophthalmologic
features are not apparent or not observed. The range of disorders that may fall
into this category is discussed. Copyright (c) 2011 Canadian Ophthalmological
Society. Published by Elsevier Inc. All rights reserved.

PMID: 22153632  [PubMed - in process]

22: Can J Ophthalmol. 2011 Dec;46(6):471-6. 

Prognostic associations of insulin-like growth factor-1 receptor in primary
uveal melanoma.

Al-Jamal RT, Kivela T.

Ophthalmic Pathology Laboratory, Department of Ophthalmology, Helsinki
University Central Hospital, Helsinki, Finland. ranaa.aljamal@hus.fi

OBJECTIVE: To study the association between immunoreactivity for insulin-like
growth factor-1 receptor (IGF-1R) in primary ciliary body and choroidal melanoma
and metastatic death in a consecutive, population-based data set. DESIGN:
Retrospective, consecutive, population-based cohort study. PARTICIPANTS: A total
of 167 patients with choroidal and ciliary body melanoma, enucleated from 1972
to 1981, with long-term survival data. METHODS: Specimens were immunostained by
using the avidin-biotinylated peroxidase complex method and polyclonal
antibodies to IGF-1R. The percentage of tumour area that was immunopositive was
recorded. Survival was assessed by Cox multivariate regression analysis.
RESULTS: The tumour area could be reliably measured from 129 (78%) of the 167
choroidal or ciliary body melanomas. More heavy pigmentation (p = 0.001), larger
number of macrophages (p = 0.003) and higher microvascular density (p = 0.060)
were associated with a higher percentage of tumour area that was immunopositive
for IGF-1R, the reverse being true of extrascleral extension (p = 0.049). No
significant association was observed with ciliary body extension, largest basal
tumour diameter, cell type, mean diameter of the 10 largest nucleoli, and
presence of extravascular matrix loops and networks (p = 0.61-0.96). The
percentage of tumour area that was immunopositive for IGF-1R was not associated
with survival. CONCLUSIONS: In our data set, immunoreactivity for IGF-IR did not
independently predict metastasis from primary uveal melanoma. Partial loss of
antigenicity can not be ruled out as a confounding factor because no frozen
sections were available. Results of previous studies have likewise been
variable, suggesting that immunohistochemical determination of IGF-1R from
formalin-fixed, paraffin-embedded specimens is not practical as a routine test.
Copyright (c) 2011 Canadian Ophthalmological Society. Published by Elsevier Inc.
All rights reserved.

Publication Types:
    Research Support, Non-U.S. Gov't

PMID: 22153631  [PubMed - in process]

23: Can J Ophthalmol. 2011 Dec;46(6):465-7. 

Comment on:
    Can J Ophthalmol. 2011 Nov;46(6 Suppl):S1-S10.

Taking on glaucoma care as an interprofessional team.

Lu VH, Lu CY, Goldberg I.

Publication Types:
    Comment
    Editorial

PMID: 22153630  [PubMed - in process]

24: Can J Ophthalmol. 2011 Dec;46(6):462-4. 

Comment on:
    Can J Ophthalmol. 2011 Nov;46(6 Suppl):S1-S10.
    Can J Ophthalmol. 2007 Feb;42(1):34-8.

A model of interprofessional collaboration in glaucoma care.

Nicolela MT.

Publication Types:
    Comment
    Editorial

PMID: 22153629  [PubMed - in process]

25: Can J Ophthalmol. 2011 Dec;46(6):460-1. 

Model of interprofessional collaboration in the care of patients with glaucoma
and those suspected of having glaucoma.

Budning A.

Publication Types:
    Editorial

PMID: 22153628  [PubMed - in process]

26: Can J Ophthalmol. 2011 Dec;46(6):458-9. Epub 2011 Aug 4. 

Interprofessional collaboration on glaucoma care.

Bellan DL.

Publication Types:
    Editorial

PMID: 22153627  [PubMed - in process]

27: Can J Ophthalmol. 2011 Dec;46(6):456-7. 

Genetic factors and AMD.

Macdonald I, Miller J.

Publication Types:
    Editorial

PMID: 22153626  [PubMed - in process]

28: Can J Ophthalmol. 2011 Dec;46(6):453-5. 

Managing antiplatelet therapy during ophthalmic procedures: communication is the
key.

Cantor WJ.

Publication Types:
    Editorial

PMID: 22153625  [PubMed - in process]