1: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-5 [Epub ahead of print] 

Heterochromia Iridis and Pertinent Clinical Findings in Patients with Glaucoma
Associated with Sturge-Weber Syndrome.

Aggarwal NK, Gandham SB, Weinstein R, Saltzmann R, Walton DS.

PURPOSE:To examine the clinical and gonioscopic findings in patients with
glaucoma associated with Sturge-Weber syndrome. METHODS:Retrospective review of
clinical findings of all patients with Sturge-Weber syndrome who presented
between January 1978 and December 2003. Koeppe gonioscopy was performed under
general anesthesia and findings were photographed when feasible. Iris color was
documented by color sketch or photograph at initial presentation. Fisher exact
test was used to determine whether the presence of heterochromia was
statistically higher in the glaucomatous group. RESULTS:Fifty-five patients who
met inclusion criteria were identified, of whom 44 (80%) had glaucoma.
Unilateral glaucoma was diagnosed in 30 eyes and bilateral glaucoma in 14 eyes,
yielding 58 eyes with glaucoma and 52 eyes without. Gonioscopic examination
revealed distinct anatomic abnormalities in the anterior chamber angle in 32
(55%) of the glaucomatous eyes in contrast to the normal fellow eyes in patients
with unilateral glaucoma and to the patients without glaucoma. Heterochromia
iridis with darker iris on the glaucomatous side was present in 11 of the 30
patients with unilateral glaucoma (37%, P < .001) but in none of the patients
without glaucoma. CONCLUSION:The characteristics observed in the anterior
chamber angle in this large, uniquely examined series are the first reported to
the authors' knowledge and may support a role for neural crest derived anomalies
in the pathogenesis of glaucoma in these infant eyes. Careful examination for
heterochromia iridis may be judicious in these patients. Copyright 2010, SLACK
Incorporated.

PMID: 20210282  [PubMed - as supplied by publisher]

2: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-3 [Epub ahead of print] 

Coats' Disease and Neovascular Glaucoma in a Child with Neurofibromatosis.

Chiu SL, Chen SN, Chen YT, Chen PJ.

This report describes an extremely rare case of Coats' disease and neovascular
glaucoma in a child with neurofibromatosis 1. Intraocular pressure control and
vision restoration were achieved with intravitreal injection with bevacizumab,
hemiretinal laser photocoagulation, peripheral retinal cryotherapy, and
trabeculectomy with mitomycin C. Copyright 2010, SLACK Incorporated.

PMID: 20210281  [PubMed - as supplied by publisher]

3: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-9 [Epub ahead of print] 

Termination of Amblyopia Treatment: When to Stop Follow-Up Visits and Risk
Factors for Recurrence.

De Weger C, Van Den Brom HJ, Lindeboom R.

BACKGROUND:This study estimated when it is safe to stop follow-up visits after
cessation of amblyopia treatment and to identify factors associated with
deterioration of visual acuity. METHODS:Study patients included 282 patients
aged 7 to 13 years who were monitored for deterioration after cessation of
amblyopia treatment (median follow-up: 3.9 years). RESULTS:Six (2.1%) patients
lost 2 or more logarithm of the minimum angle of resolution levels of visual
acuity and 77 (27.3%) patients lost 1 or more Snellen lines of visual acuity.
Good compliance with re-treatment stopped further deterioration and lost visual
acuity was regained (average follow-up after re-treatment: 3.3 years).
Life-table-analysis indicated that 95% of the cases that deteriorated occurred
within 24 months after cessation of treatment. Multivariable analysis corrected
for duration of treatment uncovered factors independently associated with
deterioration. CONCLUSION:A clinically important risk of deterioration of visual
acuity was found during the first 2 years after cessation of amblyopia
treatment. Follow-up time longer than 2 years is recommended in the presence of
a developing risk factor such as increasing anisometropia. With prompt
re-treatment and good compliance, deterioration can be stopped and visual acuity
can be restored. Copyright 2010, SLACK Incorporated.

PMID: 20210280  [PubMed - as supplied by publisher]

4: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-3 [Epub ahead of print] 

Malignant Mixed Tumor of the Lacrimal Gland in a Teenager.

Giliberti FM, Shinder R, Bell D, Savar AM, Sacks JM, Levine NB, Esmaeli B.

A 17-year-old boy presented with a painless, right superotemporal orbital mass.
Imaging demonstrated a lacrimal gland mass extending into the temporalis muscle
through the lateral orbital wall. The patient underwent an orbital exenteration.
Histopathology revealed malignant mixed tumor (carcinoma ex-pleomorphic adenoma)
of the lacrimal gland with perineural and vascular invasion. Copyright 2010,
SLACK Incorporated.

PMID: 20210279  [PubMed - as supplied by publisher]

5: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-6 [Epub ahead of print] 

Silicone-Eyelid Closure to Improve Vision in Deeply Amblyopic Eyes.

Hakim OM, El-Hag YG, Samir A.

BACKGROUND:Deep amblyopia is a recognized cause of monocular visual deficit in
children with a high rate of poor compliance with conventional occlusion
therapy. This study evaluates a new occlusion technique that can be used for
children with failed amblyopia treatment. METHODS:In a prospective study,
surgical silicone-eyelid closure was done for 15 children (age: 4 to 6 years;
median age: 5.2 years) with a history of deep amblyopia and poor compliance with
occlusion methods. In this technique, the good eye was closed by passing one
limb of a double armed 5-0 polypropylene suture from one eyelid margin through a
silicone sleeve and through the corresponding eyelid margin. The other
polypropylene limb was passed behind the silicone sleeve and then through the
opposite eyelid margin to form a barrier between the sleeve and the cornea.
After 2 to 4 weeks, the suture was cut and the silicone sleeve was removed.
RESULTS:Preoperative visual acuity ranged between counting fingers at 1 meter
and counting fingers at 4 meters. Following eyelid closure, visual acuity was
improved to between 20/40 and 20/200 for 12 patients, whereas three patients did
not improve. Complications were seen in 8 patients: marginal eyelid irritation
and erythema in 6 and suture break in 2. CONCLUSION:Silicone-eyelid closure can
be used safely and effectively for management of deep amblyopia. This technique
affords a good option to restore vision in a deeply amblyopic eye and grants the
child a lifetime of useful vision. Copyright 2010, SLACK Incorporated.

PMID: 20210278  [PubMed - as supplied by publisher]

6: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-5 [Epub ahead of print] 

Two Cases of Congenital Retrobulbar Cyst or Peripapillary Staphyloma with an
Alcoholic Mother.

Kitano A, Shirai K, Okada Y, Saika S.

The authors report two cases of congenital retrobulbar cyst or large
peripapillary staphyloma with alcoholic mothers. In the first case, a 53-day-old
newborn was referred for evaluation of microphthalmia in her left eye.
Ophthalmic examination showed microcornea, microphthalmia, and an abnormally
enlarged optic disc with an excavation in her left eye. Imaging revealed the
presence of a cystic lesion in her left orbit that seemed to be communicated
with the vitreous cavity. She did not have chromosomal abnormality. In the
second case, a large peripapillary staphyloma was detected in the right eye of a
7-month-old newborn. The mother of each patient was an alcoholic. Retrobulbar
cystic lesion or peripapillary staphyloma could be considered to be a series of
abnormalities caused by the degree of the failure of the optic cup. Effects of
each mother's alcohol intake on the development of the eye, especially the
closure of the optic cup, is to be further investigated. Copyright 2010, SLACK
Incorporated.

PMID: 20210277  [PubMed - as supplied by publisher]

7: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-4 [Epub ahead of print] 

Congenital Levator-Inferior Rectus Synkinesis.

Lee J, Kim M, Son J.

Aberrant innervation involving oculomotor nerve without evidence of antecedent
oculomotor nerve palsy is rare. Three patients with unilateral eyelid retraction
on infraduction without a history of previous oculomotor palsy were examined.
Unilateral eyelid retraction on attempted down gaze was demonstrated in all
cases and all presented with ipsilateral inferior oblique overaction to a
greater or lesser degree. Ipsilateral ptosis of the upper eyelids was observed
in primary gaze in two cases. There were no abnormal findings in biomicroscopic
and funduscopic examinations. Pupillary examinations were also unremarkable.
After repair of ptosis, the upper eyelid retraction remained and became
increased on down gaze. Surgery for repair of ipsilateral ptosis in congenital
levator-inferior rectus synkinesis should be performed cautiously because it may
aggravate the eyelid retraction on down gaze. Copyright 2010, SLACK
Incorporated.

PMID: 20210276  [PubMed - as supplied by publisher]

8: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-7 [Epub ahead of print] 

An Analysis of Neonatal Risk Factors Associated with the Development of
Ophthalmologic Problems at Infancy and Early Childhood: A Study of Premature
Infants Born at or Before 32 Weeks of Gestation.

Saldir M, Sarici SU, Mutlu FM, Mocan C, Altinsoy HI, Ozcan O.

BACKGROUND:To determine the frequency of ophthalmologic problems and the risk
factors that affect the occurrence of these problems in premature newborns with
a gestational age of 32 weeks or less. METHODS:Premature newborns observed at a
neonatal intensive care unit between January 2002 and March 2006 were included.
A control visit including an ophthalmologic examination was performed at 10
months of age or later. Primary ocular morbidities were studied, and the
association between these parameters and prenatal, perinatal, and neonatal
characteristics were evaluated. RESULTS:A total of 169 premature newborns were
included in the study, and they were examined at a mean age of 25.85 +/- 11.79
months (range: 10 to 42 months). There was complete vision loss (blindness) in 1
(0.6%) case, strabismus in 15 (8.9%) cases, and refractive errors in 10 (5.9%)
cases. Twenty (77%) cases with any abnormality and 50 (35%) cases with a normal
examination at follow-up had a history of ROP at any stage during the neonatal
period (P = .001). Short gestational age (P = .018), low birth weight (P =
.002), and the presence of ROP requiring retinal surgery during the neonatal
period (P = .007) were determined to be significant risk factors for the
development of vision loss, strabismus, and refractive errors.
CONCLUSION:Neonates with a gestational age of 32 weeks or less, especially those
younger than 30 weeks, should not only be screened for ROP in the neonatal
period, but should also have regular follow-up examinations to check for the
development of other ophthalmologic problems during infancy and early childhood.
Copyright 2010, SLACK Incorporated.

PMID: 20210275  [PubMed - as supplied by publisher]

9: J Pediatr Ophthalmol Strabismus. 2010 Feb 26;:1-4 [Epub ahead of print] 

Management of Disinserted Inferior Rectus Muscle by Fixation of Globe to the
Inferior Orbital Margin.

Saxena R, Phuljhele S, Lohiya P, Sharma P, Menon V.

Trauma to the orbital floor is often associated with trauma to the inferior
rectus muscle. The currently available options yield inconsistent postoperative
results. The authors describe a new technique in which the globe was fixed to
the inferior orbital margin with the help of a silicone band and titanium
orbital plate. Copyright 2010, SLACK Incorporated.

PMID: 20210274  [PubMed - as supplied by publisher]