1: Jpn J Ophthalmol. 2010 May;54(3):252-4. Epub 2010 Jun 25. 

Anterior ischemic optic neuropathy following intravitreal bevacizumab.

Huang JY, Ozaki H, Hayashi H, Uchio E.

Publication Types:
    Letter

PMID: 20577866  [PubMed - in process]

2: Jpn J Ophthalmol. 2010 May;54(3):250-2. Epub 2010 Jun 25. 

Bilateral exudative retinal detachment in Churg-Strauss syndrome controlled with
intravenous immunoglobulin.

Han SB, Yu HG.

Publication Types:
    Letter
    Research Support, Non-U.S. Gov't

PMID: 20577865  [PubMed - in process]

3: Jpn J Ophthalmol. 2010 May;54(3):248-50. Epub 2010 Jun 25. 

Analysis of cyclosporin A-induced reversible cortical blindness by
diffusion-weighted magnetic resonance imaging techniques.

Manabe S, Kashii S, Miki Y, Honda Y.

Publication Types:
    Letter

PMID: 20577864  [PubMed - in process]

4: Jpn J Ophthalmol. 2010 May;54(3):246-8. Epub 2010 Jun 25. 

Bilateral cytomegalovirus retinitis with unilateral optic neuritis in Good
syndrome.

Park DH, Kim SY, Shin JP.

Publication Types:
    Letter

PMID: 20577863  [PubMed - in process]

5: Jpn J Ophthalmol. 2010 May;54(3):244-6. Epub 2010 Jun 25. 

Conjunctival nevus-like lesions originating from a sclerotomy site after
23-gauge transconjunctival sutureless vitrectomy.

Park DH, Kim HK, Shin JP, Kim SY.

Publication Types:
    Letter

PMID: 20577862  [PubMed - in process]

6: Jpn J Ophthalmol. 2010 May;54(3):242-4. Epub 2010 Jun 25. 

Vascular endothelial growth factor concentrations in aqueous humor before and
after subconjunctival injection of bevacizumab for neovascular glaucoma.

Mizote M, Baba T, Hirooka K, Yamaji H, Shiraga F.

Publication Types:
    Letter

PMID: 20577861  [PubMed - in process]

7: Jpn J Ophthalmol. 2010 May;54(3):241-2. Epub 2010 Jun 25. 

Levels of soluble CD14 and lipopolysaccharide-binding protein in human basal
tears.

Fukuda K, Kumagai N, Nishida T.

Publication Types:
    Letter
    Research Support, Non-U.S. Gov't

PMID: 20577860  [PubMed - in process]

8: Jpn J Ophthalmol. 2010 May;54(3):239-41. Epub 2010 Jun 25. 

Oncocytoma of the lacrimal gland: an Asian case.

Kim JY, Park HY, Paik JS, Kim DC, Yang SW.

Publication Types:
    Letter

PMID: 20577859  [PubMed - in process]

9: Jpn J Ophthalmol. 2010 May;54(3):232-8. Epub 2010 Jun 25. 

Axial growth and binocular function following bilateral lensectomy and scleral
fixation of an intraocular lens in nontraumatic ectopia lentis.

Park SC, Chung ES, Chung TY, Kim SA, Oh SY.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University
School of Medicine, Seoul, Republic of Korea.

PURPOSE: To evaluate binocular function (BF) and changes in axial length (AL)
bilaterally in pseudophakic eyes of children after lensectomy and scleral
fixation of an intraocular lens (IOL) for nontraumatic ectopia lentis. METHODS:
In 15 children who had undergone bilateral lensectomy and scleral fixation of an
IOL for nontraumatic ectopia lentis, AL was measured preoperatively and at last
follow-up, and BF was assessed at last follow-up. Axial growth was compared with
the expected and observed patterns of normal eyes, and the results were compared
between patients with isolated ectopia lentis and those with Marfan syndrome.
RESULTS: Ten of the 15 patients had Marfan syndrome. Mean age at surgery was 5.2
+/- 2.4 years; mean follow-up was 51.7 +/- 29.2 months. A mean axial growth rate
of 0.39 mm/year during 51.7 postoperative months was greater than the expected
(0.07 mm/year) or the observed (0.09-0.24 mm/year) rates in age-matched normal
eyes. The axial growth rates in isolated ectopia lentis patients and Marfan
patients were not significantly different (P = 0.159). Binocular fusion and
stereoacuity of < or =800 seconds of arc were achieved by nine patients, and
worse or no BF was achieved by the remaining six patients. These six patients
were significantly more likely to have pre- or postoperative anisometropia of >
or =3.0 D (66.6%) than the other nine patients (0%). CONCLUSIONS: Because of
greater than normal axial growth, more undercorrection of the IOL power is
required than is usual in bilateral surgery for nontraumatic ectopia lentis.
Good or moderate levels of postoperative BF were achieved in more than half of
patients.

PMID: 20577858  [PubMed - in process]

10: Jpn J Ophthalmol. 2010 May;54(3):227-31. Epub 2010 Jun 25. 

Peripheral exudative hemorrhagic chorioretinopathy in Korean patients.

Kim YT, Kang SW, Lee JH, Chung SE.

Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University
School of Medicine, Seoul, Republic of Korea.

BACKGROUND: Peripheral exudative hemorrhagic chorioretinopathy (PEHCR) is a rare
condition characterized by either subretinal exudates or subretinal hemorrhage
outside the macula. The objective of this case report is to describe PEHCR
lesions in Korean patients. CASES: Five eyes of four patients are reviewed.
OBSERVATIONS: All cases were characterized by either peripheral subretinal
exudates or hemorrhage with age-related degeneration. Four of the lesions
appeared as subretinal masses, and the other manifested as a large retinal
pigment epithelial alteration combined with subretinal exudates and subretinal
fibrosis. Two of the patients evidenced serious visual impairment induced by
massive subretinal hemorrhage extending to the fovea. Visual acuity in the other
three eyes studied remained stable. CONCLUSION: PEHCR appears to be a variant of
age-related macular degeneration that occurs in Asians. Although PEHCR is known
to be self-limiting, it frequently causes subfoveal extensions of subretinal
blood and fluid.

PMID: 20577857  [PubMed - in process]

11: Jpn J Ophthalmol. 2010 May;54(3):221-6. Epub 2010 Jun 25. 

Expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of
MMP (TIMP)-1 in conjunctival melanomas and clinical implications.

Kim HK, Chae SW, Woo KI, Kim YD.

Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University
School of Medicine, Seoul, Korea.

PURPOSE: To investigate the expression of matrix metalloproteinase (MMP)-2,
MMP-9, and tissue inhibitor of matrix metalloproteinase (TIMP)-1 in conjunctival
melanomas and their correlations with clinicopathologic parameters and
prognosis. METHODS: Fourteen conjunctival melanoma tissue samples and nine
conjunctival nevus tissue samples were stained immunohistochemically for MMP-2,
MMP-9, and TIMP-1. Association of MMP-2, MMP-9, and TIMP-1 expression in
melanoma tissues with clinical progression in terms of metastasis, recurrence,
mitotic index, thickness, base diameter, and invasion depth was analyzed.
RESULTS: In the melanoma group, 78.6% of samples showed a positive reaction for
MMP-2, 85.7% for MMP-9, and 100% for TIMP-1. In the nevus group, 11.1% showed a
positive reaction for MMP-2, 66.7% for MMP-9, and 100% for TIMP-1. MMP-2
expression was significantly more induced in conjunctival melanoma than in
benign nevi (P = 0.002). In conjunctival melanoma, MMP-9 expression was higher
in tumors >1.5 mm thick (P = 0.026) and TIMP-1 expression was higher in
recurrent cases (P = 0.03). There was no significant correlation between the
expression and metastasis during the follow-up period (mean, 5 years).
CONCLUSION: MMP-2, MMP-9, and TIMP-1 were expressed in the majority of
conjunctival melanomas, and MMP-2 might play a role in the development and
clinical behavior of conjunctival melanoma.

Publication Types:
    Research Support, Non-U.S. Gov't

PMID: 20577856  [PubMed - in process]

12: Jpn J Ophthalmol. 2010 May;54(3):215-20. Epub 2010 Jun 25. 

Using synthesized onion lachrymatory factor to measure age-related decreases in
reflex-tear secretion and ocular-surface sensation.

Higashihara H, Yokoi N, Aoyagi M, Tsuge N, Imai S, Kinoshita S.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto,
Japan.

PURPOSE: To use synthesized onion lachrymatory factor (SOLF) to investigate
age-related changes in reflex-tear secretion and ocular-surface sensation.
METHODS: We separated 91 healthy volunteers into four groups: groups A, age
20-29 years; B, 30-39; C, 40-49; and D, older than 50 years. We exposed one eye
of each subject to SOLF and measured the elapsed time until the subject's limit
of irritation tolerance (TLI) was reached and an increase in the tear meniscus
radius (DeltaR). After the SOLF stimulus, corneal sensitivity was examined by
Cochet-Bonnet esthesiometry (CB), and reflex-tear secretion was examined by the
Schirmer I-test (ST). RESULTS: TLI was significantly shorter in group A than in
the other groups (P < 0.0001), and the groups B and D also differed
significantly from each other (P = 0.0013). The increase in DeltaR was
significantly greater in group A than in group C (P = 0.0306) or D (P < 0.0001),
and groups B (P = 0.0002) and C (P = 0.0308) also differed significantly from
group D. There were no significant intergroup differences in the CB and ST
results. CONCLUSIONS: An age-related decrease in reflex-tear secretion and
ocular-surface sensation was revealed by the SOLF test but could not be detected
by either CB or the ST.

PMID: 20577855  [PubMed - in process]

13: Jpn J Ophthalmol. 2010 May;54(3):211-4. Epub 2010 Jun 25. 

Biology of corneal endothelial cells in vivo and in vitro.

Amano S, Kaji Y, Mimura T.

Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo,
Japan. amanos-tky@umin.ac.jp

PMID: 20577854  [PubMed - in process]

14: Jpn J Ophthalmol. 2010 May;54(3):206-10. Epub 2010 Jun 25. 

Corneal morphogenesis during development and wound healing.

Kao WW, Liu CY.

Department of Ophthalmology, College of Medicine, University of Cincinnati,
Cincinnati, OH 45267-0838, USA. Winston.Kao@UC.edu

PMID: 20577853  [PubMed - in process]

15: Jpn J Ophthalmol. 2010 May;54(3):199-205. Epub 2010 Jun 25. 

Wound healing fibroblasts modulate corneal angiogenic privilege: interplay of
basic fibroblast growth factor and matrix metalloproteinases in corneal
angiogenesis.

Chang JH, Han KY, Azar DT.

Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary,
University of Illinois at Chicago, Chicago, IL 60612, USA.

Publication Types:
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

PMID: 20577852  [PubMed - in process]

16: Jpn J Ophthalmol. 2010 May;54(3):194-8. Epub 2010 Jun 25. 

Innate immunity of the ocular surface.

Kinoshita S, Ueta M.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto,
Japan. shigeruk@koto.kpu-m.ac.jp

PMID: 20577851  [PubMed - in process]

17: Jpn J Ophthalmol. 2010 May;54(3):191-3. Epub 2010 Jun 25. 

Host-pathogen interactions in the cornea.

Suzuki T, Yamada A, Gilmore MS.

Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical
School, Boston, MA 02114, USA.

PMID: 20577850  [PubMed - in process]

18: Jpn J Ophthalmol. 2010 May;54(3):187-90. Epub 2010 Jun 25. 

Suppression of herpes simplex virus 1 reactivation in a mouse eye model by
cyclooxygenase inhibitor, heat shock protein inhibitor, and adenosine
monophosphate.

Shimomura Y, Higaki S, Watanabe K.

Kinki University School of Medicine, Osaka, Japan. yoshis@med.kindai.ac.jp

PMID: 20577849  [PubMed - in process]

19: Jpn J Ophthalmol. 2010 May;54(3):182-6. Epub 2010 Jun 25. 

Anterior segment mechanisms of protection during herpes simplex virus 1
infection.

Atherton SS, Cathcart HM.

Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta,
GA 30912, USA. satherton@mail.mcg.edu

Publication Types:
    Research Support, N.I.H., Extramural

PMID: 20577848  [PubMed - in process]

20: Jpn J Ophthalmol. 2010 May;54(3):179-81. 

2009 ARVO-JOS Symposium.

Kinoshita S.

Kyoto Prefectural University of Medicine, Kyoto, Japan.

Publication Types:
    Introductory Journal Article

PMID: 20577847  [PubMed - in process]