1: Acta Ophthalmol Scand. 2007 Dec;85(8):911-3. 

Expression of interleukin-6, tumour necrosis factor-alpha and nitric oxides
during episodes of ocular toxoplasmosis in an HIV patient.

Prada J, Liekfeld A, Bergmann F, Grobusch MP.

Publication Types:
    Case Reports
    Letter
    Research Support, Non-U.S. Gov\'t

PMID: 18028121 [PubMed - indexed for MEDLINE]

2: Acta Ophthalmol Scand. 2007 Dec;85(8):907-8. 

Varicella chorioretinitis.

Aslan O, Soykan E, Ozkan SS.

Department of Retina, M.H. Ulucanlar Eye Education and Research Hospital,
Ankara, Turkey. aslanozlem@hotmail.com

Publication Types:
    Case Reports

PMID: 18028120 [PubMed - indexed for MEDLINE]

3: Acta Ophthalmol Scand. 2007 Dec;85(8):822-7. 

Pseudoexfoliation in the Reykjavik Eye Study: prevalence and related
ophthalmological variables.

Arnarsson A, Damji KF, Sverrisson T, Sasaki H, Jonasson F.

Department of Ophthalmology, University of Iceland, Reykjavik, Iceland.

PURPOSE: To examine the age and sex-specific prevalence of pseudoexfoliation
syndrome (PEX) and its relationship with some ophthalmological variables.
METHODS: We carried out a population-based study using a random sample taken
from the national population census for citizens of Reykjavik, aged > or = 50
years. A total of 1045 individuals participated in all parts of the study.
Pseudoexfoliation was established by slit-lamp examination with a maximally
dilated pupil carried out by two experienced ophthalmologists, who were masked
to one another\'s results except in cases of disagreement where they had to reach
a consensus. RESULTS: In all, 108 (10.7%) persons were found to have PEX in at
least one eye. Prevalence increased from 2.5% in those aged 50-59 years to 40.6%
in those aged > or = 80 years. Women were more frequently affected than men
(12.3% versus 8.7%). This difference remained statistically significant after
controlling for the effect of age (p < 0.001). Eyes with PEX were found to have
higher intraocular pressure (IOP) than eyes without PEX (p < 0.05). However, PEX
was not found to be related to central corneal thickness, anterior chamber
depth, lens thickness, nuclear lens opacifications or optic disc morphology in a
multivariate model. CONCLUSIONS: Pseudoexfoliation is an age-related phenomenon
commonly found in Iceland. It is more commonly found in women than in men and is
associated with elevated IOP.

Publication Types:
    Research Support, Non-U.S. Gov\'t

PMID: 18028119 [PubMed - indexed for MEDLINE]

4: Acta Ophthalmol Scand. 2007 Dec;85(8):808-9. 

Solving the enigma of exfoliation glaucoma: a breakthrough in glaucoma research.

Jonasson F.

Publication Types:
    Editorial

PMID: 18028118 [PubMed - indexed for MEDLINE]

5: Acta Ophthalmol Scand. 2007 Dec;85(8):832-7. Epub 2007 Nov 6. 

Comment in:
    Acta Ophthalmol Scand. 2007 Aug;85(5):470-1.

Incidence and prevalence of pseudoexfoliations and open-angle glaucoma in
northern Sweden: II. Results after 21 years of follow-up.

Astrom S, Stenlund H, Linden C.

Department of Clinical Sciences, Ophthalmology, Umea University, Umea, Sweden.
siv.astrom@vll.se

PURPOSE: To prospectively evaluate the prevalence and incidence of
pseudoexfoliation (PEX) syndrome and open-angle glaucoma (OAG) with and without
PEX and to evaluate PEX as a risk factor for glaucoma in a population born in
1915 and living in the municipality of Skelleftea in northern Sweden. METHODS: A
randomized population study comprising 339 individuals. The cohort was followed
for 21 years at 7 year intervals. The examination included tonometry, dilated
slit-lamp biomicroscopy, optic disc evaluation and, if glaucoma was suspected, a
visual field analysis. RESULTS: The prevalence of PEX increased from 23%[95%
confidence interval (CI): 20-26] at 66 years of age to 61% (CI 50-71) at 87
years. The annual incidence of PEX was 1.8% (CI 1.3-2.4). In the group of
subjects with unilateral PEX, 55% converted to bilateral PEX during follow-up.
The prevalence of OAG was 2.1% (CI 0.8-4.3%) at 66 years of age and 25% (CI
16-35) at 87 years. Of the glaucoma cases, 59% had PEX. There was no difference
in incidence between the sexes. The annual incidence of PEX and OAG did not
increase with time. The overall annual incidence of OAG was 0.9% (CI 0.6-1.3%)
[0.5% (CI 0.2-0.9) without PEX and 2.1% (CI 1.2-3.3) with PEX]. PEX increased
the risk of glaucoma four fold in both sexes. There was no significant
difference in mortality between individuals with or without PEX. CONCLUSION: PEX
syndrome and OAG are common in the north of Sweden. Prevalences increase with
age. PEX increases the risk of glaucoma four fold. The consequences of this
situation demand guidelines for handling patients with PEX, with or without
other risk factors. In order to issue guidelines, more information is needed on
the impact of the disease on the general health in the ageing population.

Publication Types:
    Research Support, Non-U.S. Gov\'t

PMID: 17986292 [PubMed - indexed for MEDLINE]

6: Acta Ophthalmol Scand. 2007 Dec;85(8):828-31. Epub 2007 Nov 6. 

Incidence and prevalence of pseudoexfoliation and open-angle glaucoma in
northern Sweden: I. Baseline report.

Astrom S, Linden C.

Department of Clinical Sciences, Ophthalmology, Umea University, Umea, Sweden.
siv.astrom@vll.se

PURPOSE: To evaluate the prevalence of pseudoexfoliation (PEX) syndrome and
open-angle glaucoma (OAG) among 66-year-old people in the municipality of
Skelleftea in northern Sweden. METHODS: A population-based study comprising 339
individuals, representing 40% of the age group and 87% of those randomly
selected. The examination included tonometry, dilated slit-lamp biomicroscopy,
optic disc evaluation and a visual field analysis if glaucoma was suspected.
RESULTS: The overall prevalence of PEX syndrome was 23%[95% confidence interval
(CI): 20-26%], 29% (CI: 24-34%) in women and 15% (CI: 10-19%) in men (P < 0.01).
The intraocular pressure (IOP) in PEX eyes was higher (17.3 mmHg, SD 4.5 mmHg)
than in eyes without PEX [15.7 mmHg, SD 3.7 mmHg; P < 0.001]. IOP exceeded 22
mmHg in 17% (CI: 11-23%) of the PEX eyes and in 3.0% (CI: 1.9-4.1%) of the
non-PEX eyes. Seven individuals (2.1%) had OAG. Six were associated with PEX,
i.e. 7.7% of the PEX individuals. CONCLUSION: PEX syndrome is common in northern
Sweden, affecting every fourth individual reaching the age of 66 years. The
prevalence in women is twice that in men. Elevated IOP is roughly six times more
frequent in eyes with PEX than in eyes without PEX syndrome. The prevalence of
OAG is 2.1%.

Publication Types:
    Research Support, Non-U.S. Gov\'t

PMID: 17986290 [PubMed - indexed for MEDLINE]