Journal Contents

Am Jour Ophthalmol
Br J Ophthalmol
Can J Ophthalmol
J Cat Ref Surg
Curr Eye Res
Eur J Ophthalmol
J Glaucoma
JAMA Ophthalmol
Graefes Ophthalmol
Indian J Ophthalmol
Int Ophthalmol Clin
Invest Ophth Vis Sci
Jpn J Ophthalmol
Korean J Ophthal
J Neuroophthalmol
Ophthalmic Epidemiol
Ophthalmic Genet
Ophthal Plast Rec Surg
Ophthalmic Res
Surv Ophthalmol
Ophthalmology Review Journal
Korean J Ophthalmol[JOUR] Established 1995
1. Korean J Ophthalmol. 2015 Oct;29(5):357-8. doi: 10.3341/kjo.2015.29.5.357. Epub
2015 Sep 22.

Optic Disc Edema Responding to Localized Anti-vascular Endothelial Growth Factor 
Treatment in a Patient with POEMS Syndrome.

Song HB(1), Yu HG(2).

Author information: 
(1)Department of Biomedical Sciences, Seoul National University College of
Medicine, Seoul, Korea. (2)Department of Ophthalmology, Seoul National University
Hospital, Seoul National University College of Medicine, Seoul, Korea.

PMCID: PMC4595265
PMID: 26457045   [PubMed - in process]

2. Korean J Ophthalmol. 2015 Oct;29(5):354-6. doi: 10.3341/kjo.2015.29.5.354. Epub
2015 Sep 22.

Intravitreal Bevacizumab for the Treatment of Optic Disc Edema in a Patient with 
POEMS Syndrome.

Kim do W(1), Kang SY(2), Bae HW(1), Hong S(1), Seong GJ(1), Kim CY(1).

Author information: 
(1)Department of Ophthalmology, Institute of Vision Research, Severance Hospital,
Yonsei University College of Medicine, Seoul, Korea. (2)Eyereum Ophthalmic
Clinic, Seoul, Korea.

PMCID: PMC4595264
PMID: 26457044   [PubMed - in process]

3. Korean J Ophthalmol. 2015 Oct;29(5):352-4. doi: 10.3341/kjo.2015.29.5.352. Epub
2015 Sep 22.

Recurrent Unilateral Vogt-Koyanagi-Harada Disease with Posterior Scleritis.

Moon SY(1), Yoon WT(1), Park SP(1).

Author information: 
(1)Department of Ophthalmology, Kangdong Sacred Heart Hospital, Hallym University
College of Medicine, Seoul, Korea.

PMCID: PMC4595263
PMID: 26457043   [PubMed - in process]

4. Korean J Ophthalmol. 2015 Oct;29(5):351-2. doi: 10.3341/kjo.2015.29.5.351. Epub
2015 Sep 22.

The Relationships between Anterior Chamber Parameters and Obesity.

Lee SJ(1), Kim M(1), Kim SK(1), Han SB(1).

Author information: 
(1)Department of Ophthalmology, Kangwon National University Hospital, Kangwon
National University School of Medicine, Chuncheon, Korea.

PMCID: PMC4595262
PMID: 26457042   [PubMed - in process]

5. Korean J Ophthalmol. 2015 Oct;29(5):344-50. doi: 10.3341/kjo.2015.29.5.344. Epub 
2015 Sep 22.

Comparison of Cytotoxic Effects on Rabbit Corneal Endothelium between
Preservative-free and Preservative-containing Dorzolamide/timolol.

Kwon J(1), Heo JH(1), Kim HM(1), Song JS(1).

Author information: 
(1)Department of Ophthalmology, Korea University College of Medicine, Seoul,

PURPOSE: To evaluate and compare the toxic effects of eyedrops containing a fixed
combination of 2.0% dorzolamide and 0.5% maleate timolol with or without
preservatives on rabbit corneal endothelium.
METHODS: This study was performed with 22 eyes of New Zealand white rabbits.
Dorzolamide/timolol eyedrops with preservative (Cosopt group) or without
preservative (Cosopt-S group) were diluted with a balanced salt solution at a 1 :
1 ratio. We injected 0.1 mL of diluted Cosopt into the anterior chamber of left
eyes and an equal volume of diluted Cosopt-S into the anterior chamber of right
eyes. Corneal thickness, corneal haze, and conjunctival injection were measured
before and 24 hours after treatment. Endothelial damage was compared between both
eyes by vital staining (alizarin red/trypan blue staining), live/dead cell assay,
TUNEL assay, and scanning electron microscopy.
RESULTS: Corneal endothelial damage was severe in the Cosopt group.
Cosopt-treated eyes exhibited remarkable corneal edema and prominent apoptosis of
endothelial cells. In addition, the live/dead cell assay revealed many dead cells
in the endothelium, and scanning electron microscopy analysis showed that corneal
endothelial cells exhibited a partial loss of microvilli on the surface as well
as extensive destruction of intercellular junctions. However, in the Cosopt-S
group, corneal edema was mild and the damage to the corneal endothelium was
CONCLUSIONS: The main cause of corneal endothelial toxicity was due to the
preservative in the dorzolamide/timolol fixed combination eyedrops, and not the
active ingredient. Thus, it appears to be safer to use preservative-free eyedrops
during the early postoperative period.

PMCID: PMC4595261
PMID: 26457041   [PubMed - in process]

6. Korean J Ophthalmol. 2015 Oct;29(5):336-43. doi: 10.3341/kjo.2015.29.5.336. Epub 
2015 Sep 22.

Associations between Optic Cup-to-disc Ratio and Systemic Factors in the Healthy 
Korean Population.

Kim YJ(1), Kim JM(1), Shim SH(1), Bae JH(1), Park KH(2); Epidemiologic Survey
Committee of the Korean Ophthalmological Society.

Author information: 
(1)Department of Ophthalmology, Kangbuk Samsung Hospital, Sungkyunkwan University
School of Medicine, Seoul, Korea. (2)Department of Ophthalmology, Seoul National 
University College of Medicine, Seoul, Korea.

PURPOSE: To assess the relationships between optic cup-to-disc ratio (CDR) and
age, sex, and other demographic and health characteristics in the healthy Korean 
METHODS: The study design was retrospective and population-based. A total of
28,377 subjects who participated in the Korea National Health and Nutrition
Examination Survey between 2008 and 2011 were enrolled in this study.
Participants underwent structured interviews as well as systemic and ophthalmic
examinations. Patients with glaucoma who were diagnosed using the International
Society of Geographical and Epidemiological Ophthalmology classification were
excluded. Changes in vertical CDR were examined by age in relation to systemic
variables on multiple regression analysis.
RESULTS: The mean vertical CDR was 0.34 ± 0.12. The vertical CDR increased with
age from subjects in their 20s to those in their 80s (p < 0.001). The mean CDR in
males was significantly higher than that of females (p < 0.001). On multiple
regression analysis, the vertical CDR was positively associated with age (p <
0.001), male sex (p < 0.001), diastolic blood pressure (p = 0.009), and
intraocular pressure (p < 0.001) but was negatively associated with body mass
index (p < 0.001).
CONCLUSIONS: Greater vertical CDR was related to age, male sex, higher diastolic 
blood pressure, higher intraocular pressure, and lower body mass index in healthy

PMCID: PMC4595260
PMID: 26457040   [PubMed - in process]

7. Korean J Ophthalmol. 2015 Oct;29(5):331-5. doi: 10.3341/kjo.2015.29.5.331. Epub
2015 Sep 22.

Structural and Functional Outcomes in Chronic Central Serous Chorioretinopathy
Treated with Photodynamic Therapy.

Cidad P(1), González E(1), Asencio M(1), García J(1).

Author information: 
(1)Ophthalmology Service, Hospital Universitario La Paz, Madrid, Spain.

PURPOSE: To study the retinal pigment epithelium (RPE) and retinal alterations in
chronic central serous chorioretinopathy treated with photodynamic therapy, and
its correlation with functional parameters such as best-corrected visual acuity
(BCVA) and contrast sensitivity (CS).
METHODS: Retrospective, noncomparative, consecutive evaluation by optical
coherence tomography and its correlation with BCVA and CS in 31 eyes of 26
RESULTS: In all affected patients, 88.5% were male with a mean age of 42.9 years.
The right eye was involved in 64.5% of cases, bilateral in 19% and 73.9% were
hyperopic (spherical refraction between 0 and +5.0 diopters). Of these cases,
51.5% had peri-RPE abnormalities, 17.3% hyperreflective substances at RPE, 19.4% 
RPE atrophy, 55.3% foveolar atrophy, 3.1% pigment epithelial detachment, 5.2%
subretinal fluid persistence, 8.3% fibrin deposits, 68.4% photoreceptor inner and
outer segment line interruption and 31.1% external limiting membrane
CONCLUSIONS: Time evolution and number of outbreaks were related to the decrease 
in foveal and chorodial thickness and in those with worse BCVA and CS. RPE
abnormalities and atrophy were related to the age of onset of symptoms.
Photoreceptor elongation has been correlated with poor BCVA and inner and outer
segment line destructuring and interruption with poor CS.

PMCID: PMC4595259
PMID: 26457039   [PubMed - in process]

8. Korean J Ophthalmol. 2015 Oct;29(5):325-30. doi: 10.3341/kjo.2015.29.5.325. Epub 
2015 Sep 22.

Sterile Inflammation after Intravitreal Injection of Aflibercept in a Korean

Kim JY(1), You YS(1), Kwon OW(1), Kim SH(1).

Author information: 
(1)Nune Eye Hospital, Seoul, Korea.

PURPOSE: To report the frequency and clinical features of sterile inflammation
after intravitreal aflibercept injection in a Korean population.
METHODS: A single-center, retrospective study was performed in patients who
received intravitreal aflibercept from July 2013 through January 2015.
RESULTS: A total of four cases of post-injection sterile inflammation were
identified from 723 aflibercept injections in 233 patients. Patients presented 1 
to 13 days after intravitreal aflibercept injection (mean, 5 days). The mean
baseline visual acuity was 20 / 60, which decreased to 20 / 112 at diagnosis but 
ultimately recovered to 20 / 60. Three cases had inflammatory cells in the
anterior chamber (mean, 2.25+; range, 0 to 4+), and all cases had vitritis (mean,
3+; range, 2+ to 4+). No patients had pain. Only one patient underwent anterior
chamber sampling (culture negative) and injection of antibiotics. Three of four
patients were treated with a topical steroid, and all experienced improvement in 
their symptoms and signs of inflammation.
CONCLUSIONS: The overall incidence of sterile inflammation after intravitreal
aflibercept injection in a Korean population was 4 of 723 injections (0.55%), or 
4 of 233 patients (1.79%). Sterile inflammation after intravitreal aflibercept
injection typically presents without pain, and the visual outcomes are generally 

PMCID: PMC4595258
PMID: 26457038   [PubMed - in process]

9. Korean J Ophthalmol. 2015 Oct;29(5):315-24. doi: 10.3341/kjo.2015.29.5.315. Epub 
2015 Sep 22.

Clinical Outcomes of Eyes with Submacular Hemorrhage Secondary to Age-related
Macular Degeneration Treated with Anti-vascular Endothelial Growth Factor.

Kim KH(1), Kim JH(1), Chang YS(2), Lee TG(1), Kim JW(1), Lew YJ(1).

Author information: 
(1)Department of Ophthalmology, Kim's Eye Hospital, Konyang University College of
Medicine, Seoul, Korea. (2)Department of Ophthalmology, Konyang University
College of Medicine, Daejeon, Korea.

PURPOSE: To evaluate the long-term outcomes of intravitreal anti-vascular
endothelial growth factor (VEGF) monotherapy for patients diagnosed with
submacular hemorrhage secondary to exudative age-related macular degeneration.
METHODS: This retrospective, observational study included 49 patients (49 eyes)
who initially presented with submacular hemorrhage associated with exudative
age-related macular degeneration and who were followed-up for at least 24 months.
Only eyes that were treated with intravitreal anti-VEGF monotherapy were included
in the study. Best-corrected visual acuity (BCVA) measurements obtained at
diagnosis, six months, and the final visit were compared. The associations of
BCVA at the final visit with baseline BCVA, BCVA at six months, symptom duration,
hemorrhage extent, and central foveal thickness were also analyzed.
RESULTS: Over the course of follow-up (mean, 32.1 ± 8.5 months), an average of
5.1 ± 2.2 anti-VEGF injections were administered. Recurrent hemorrhage was noted 
in 13 eyes (26.5%). The mean logarithm of the minimal angle of resolution BCVA at
diagnosis, six months, and the final visit were 1.40 ± 0.52, 0.87 ± 0.64, and
1.03 ± 0.83, respectively. Both baseline BCVA (p = 0.012) and BCVA at six months 
(p < 0.001) were significantly associated with BCVA at the final visit.
CONCLUSIONS: Improved visual acuity was maintained for more than two years with
intravitreal anti-VEGF monotherapy. BCVA at six months is a useful clinical index
to predict long-term visual prognosis.

PMCID: PMC4595257
PMID: 26457037   [PubMed - in process]

10. Korean J Ophthalmol. 2015 Oct;29(5):309-14. doi: 10.3341/kjo.2015.29.5.309. Epub 
2015 Sep 22.

Choroidal Blood Flow Change in Eyes with High Myopia.

Yang YS(1), Koh JW(1).

Author information: 
(1)Department of Ophthalmology, Chosun University School of Medicine, Gwangju,

PURPOSE: To evaluate choroidal blood flow changes in eyes with high myopia
according to the pulsatile components of ocular blood flow analysis.
METHODS: A total of 104 subjects (52 males and 52 females) were included in this 
study. One eye of each participant was randomly selected and assigned to one of
four refractive groups, designated as, hyperopes (n = 20; refractive error,
≥+1.00 diopter [D]), emmetropes (n = 28; refractive error, ±0.75 D), lower myopes
(n = 33; refractive error, -1.00 to -4.75 D), and high myopes (n = 23; refractive
error, ≤-5.00 D). Components of pulse amplitude (OBFa), pulse volume (OBFv),
pulse rate (OBFr), and pulsatile ocular blood flow (POBF) were analyzed using a
blood flow analyzer. Intraocular pressure and axial length were measured.
RESULTS: Pulsatile components of OBFa, OBFv, and POBF showed positive
correlations with refractive error and showed negative correlations with axial
length (r = 0.729, r = 0.772, r = 0.781, respectively, all p < 0.001; r = -0.727,
r = -0.762, r = -0.771, respectively, all p < 0.001). The correlations of
refractive error and axial length with OBFr were irrelevant (r = -0.157, p =
0.113; r = 0.123, p = 0.213). High myopes showed significantly lower OBFa, OBFv, 
and POBF than the other groups (all p < 0.001).
CONCLUSIONS: Axial length changes in high myopes potentially influence choroidal 
blood flow, assuming the changes are caused by narrowing of the choroidal vessel 
diameter and increasing rigidity of the choroidal vessel wall. These finding
explains the influence of axial length on OBFa, OBFv, and POBF, but not on OBFr. 
Thus, changes in axial length and the possible influence of these changes on the 
physical properties of choroidal vessels is the mechanism believed to be
responsible for putting high myopes at risk for ocular vascular diseases.

PMCID: PMC4595256
PMID: 26457036   [PubMed - in process]

11. Korean J Ophthalmol. 2015 Oct;29(5):301-8. doi: 10.3341/kjo.2015.29.5.301. Epub
2015 Sep 22.

Factors Affecting Treatment Outcome of Graft Infection Following Penetrating

Sung MS(1), Choi W(1), You IC(2), Yoon KC(1).

Author information: 
(1)Department of Ophthalmology and Research Institute of Medical Sciences,
Chonnam National University Hospital, Chonnam National University Medical School,
Gwangju, Korea. (2)Department of Ophthalmology, Chonbuk National University
Hospital, Chonbuk National University Medical School, Jeonju, Korea.

PURPOSE: To evaluate the factors affecting treatment outcome of graft infection
following penetrating keratoplasty (PKP).
METHODS: In this retrospective study, 28 patients who underwent PKP between
January 2005 and January 2013 and who were diagnosed with graft infection were
classified into a treatment success group or a treatment failure group.
Demographic and clinical characteristics, as well as the results of the
microbiologic investigation, were analyzed and compared. A subsequent binary
logistic regression analysis was performed to identify the prognostic factors
affecting treatment outcome.
RESULTS: Graft infection occurred at a mean of 38.29 ± 36.16 months (range, 1 to 
96 months) after PKP. Seventeen patients developed bacterial keratitis, and 11
patients developed fungal keratitis. Overall, of the 28 patients, nine (32.1%)
were classified in the treatment failure group. Multivariate analysis identified 
pre-existing graft failure (p = 0.019), interval longer than 72 hours between
donor death and PKP (p = 0.010), and fungal infection (p = 0.026) as significant 
risk factors for treatment failure.
CONCLUSIONS: Pre-existing graft failure, extended interval between donor death
and PKP, and fungal infection were important risk factors for treatment failure
of graft infection following PKP.

PMCID: PMC4595255
PMID: 26457035   [PubMed - in process]

12. Korean J Ophthalmol. 2015 Oct;29(5):294-300. doi: 10.3341/kjo.2015.29.5.294. Epub
2015 Sep 22.

Long-term Surgical Outcomes of the Multi-purpose Conical Porous Synthetic Orbital

Kang MJ(1), Jung SK(2), Cho WK(3), Paik JS(1), Yang SW(1).

Author information: 
(1)Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, The
Catholic University of Korea College of Medicine, Seoul, Korea. (2)Department of 
Ophthalmology, Bucheon St. Mary's Hospital, The Catholic University of Korea
College of Medicine, Bucheon, Korea. (3)Department of Ophthalmology, Daejeon St. 
Mary's Hospital, The Catholic University of Korea College of Medicine, Daejeon,

PURPOSE: We present clinical results of the use of the multipurpose conical
porous synthetic orbital implant (MCOI) in surgical procedures of evisceration,
enucleation, and secondary enucleation in ophthalmology patients.
METHODS: A retrospective review was performed of 59 eyes in which conical
implants were used, including 36 cases of eviscerations, 11 enucleations, and 9
secondary enucleations. In all of the cases, the follow-up period was greater
than six months between 2004 and 2013. The results focus on documenting surgical 
findings, as well as postoperative complications among patients.
RESULTS: Superior sulcus deformities were found in six eyes (10.2% of conical
implant patients), and two eyes received additional surgical interventions to
correct the deformities (3.4%). Blepharoptosis was found in four eyes (6.8%), two
of which received upper eyelid blepharoplasty (3.4%). Fornix shortening was
reported in only one eye (1.7%). Forty-one eyes had a satisfactory cosmetic
appearance after the final prosthetic fitting of conical implants (69.5%). The
most frequent postoperative complication was orbital implant exposure, which
seemed to occur when the preoperative status of the conjunctiva, Tenon's capsule,
and sclera preservation were poor in the eyes of the patients.
CONCLUSIONS: There was a lower incidence of blepharoptosis and fornix shortening 
with the MCOI in comparison to spherical implants, while the incidence of orbital
implant exposure was similar with the MCOI in comparison to other types of
orbital implants. In addition, the MCOI may have advantages with respect to
postoperative cosmetic outcomes.

PMCID: PMC4595254
PMID: 26457034   [PubMed - in process]

13. Korean J Ophthalmol. 2015 Oct;29(5):285-93. doi: 10.3341/kjo.2015.29.5.285. Epub 
2015 Sep 22.

Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of
Korean Patients.

Choung H(1), Kim YA(2), Kim N(3), Lee MJ(4), Khwarg SI(5).

Author information: 
(1)Department of Ophthalmology, Seoul Metropolitan Government-Seoul National
University Boramae Medical Center, Seoul National University College of Medicine,
Seoul, Korea. (2)Department of Pathology, Seoul Metropolitan Government-Seoul
National University Boramae Medical Center, Seoul, Korea. (3)Department of
Ophthalmology, Seoul National University Bundang Hospital, Seoul National
University College of Medicine, Seongnam, Korea. (4)Department of Ophthalmology, 
Hallym University Sacred Heart Hospital, Anyang, Korea. (5)Department of
Ophthalmology, Seoul National University Hospital, Seoul National University
College of Medicine, Seoul, Korea.

PURPOSE: The incidence and clinical correlation of MALT1 translocation and
chromosomal numerical aberrations in Korean patients with ocular adnexal mucosa
associated lymphoid tissue (MALT) lymphoma have not yet been reported. We
investigated the incidence and clinicopathologic relationship of these
chromosomal aberrations in ocular adnexal MALT lymphomas in a Korean population.
METHODS: Thirty ocular adnexal MALT lymphomas were investigated for the t(11;18) 
API2-MALT1, t(14;18) IgH-MALT1 translocations and chromosomes 3 and 18
aneuploidies using fluorescence in situ hybridization. Patient medical records
were reviewed retrospectively for information on demographics and clinical
characteristics, including treatment response.
RESULTS: The MALT1 gene rearrangement was found in one out of 30 cases. The
t(14;18) IgH-MALT1 translocation was demonstrated in only one case (3.3%), and
the t(11;18) API2-MALT1 translocation was not found in any of the cases. Trisomy 
3 was observed in three ocular adnexal MALT lymphomas (10.0%), and five cases
showed trisomy 18 (16.7%). Translocation positive cases also showed trisomy 18.
One case of tumor relapse showed trisomy 18 only in the recurrent biopsies. There
were no statistically significant correlations between chromosomal aberrations
and clinical characteristics and treatment responses.
CONCLUSIONS: Translocations involving the MALT1 gene are not common in Korean
ocular adnexal MALT lymphomas. The t(14;18) translocation was detected in only
one out of 30 cases, and the t(11;18) translocation was not found at all.
Furthermore, the chromosomal aberrations found in this study had no prognostic

PMCID: PMC4595253
PMID: 26457033   [PubMed - in process]